DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment blot and Slc6a1

DIOPT Version :9

Sequence 1:	NP_524125.2	Gene:	blot / 39939	FlyBaseID:	FBgn0027660	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_077347.1	Gene:	Slc6a1 / 79212	RGDID:	620533	Length:	599	Species:	Rattus norvegicus

Alignment Length:	576	Identity:	128/576 - (22%)
Similarity:	232/576 - (40%)	Gaps:	114/576 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 ISASAHNITTASN------AKLLPAVEDESNKQTKCSVFRGLVLCLCLNLSYANVVRFPRELDRY 245
            ||........||:      .|:.....|..::.|....|..|:.|:...:...||.|||....:.
  Rat    13 ISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKN 77

  Fly   246 -GSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQGAAHTWRASPIFKGACMISRFAS-WLSAIWVS 308
             |.|:|:||.:.|...|:|:.|||.|:||:...|....|:.:|:|||..:.:...| ||:..::.
  Rat    78 GGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIV 142

  Fly   309 LQAVLALAYIGMFASNDLPFRECAGP--VKLRLSGYLLTGTSGQECLQLTFLTPFWRNPLY---F 368
            :.: .|:.|:....:..||:::|..|  .....|.|.|..|:.    ..:.:..||...::   .
  Rat   143 IIS-WAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLVNTTN----MTSAVVEFWERNMHQMTD 202

  Fly   369 GL---------LAAGLIGLWIVVMLCT-----HNAKILRRSIFVFGLVGLVLL----CTLTGWEV 415
            ||         ||..|...|::|..|.     ...|::..|. .:..:.|::|    .||.|  .
  Rat   203 GLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVVYFSA-TYPYIMLIILFFRGVTLPG--A 264

  Fly   416 RNSFSRHYFPELWGFDSNLLAESNIWFNALMQVLFSVNCGFGALPMITGKFLYKGDAVRTSVVYL 480
            :.....:..|..     ..|::|.:|.:|..|:.||...|.|:|..:.....:..:..|.|::..
  Rat   265 KEGILFYITPNF-----RKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVC 324

  Fly   481 CFNLLINAIA--VTLFMVQF----------DLSSNG----FQNMEE------LKPLTAIYDRVLN 523
            |.|...:..|  |...:|.|          |::::|    |....|      :.||.||
  Rat   325 CINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAI------ 383

  Fly   524 GSREGDSHLLQHLVPSLIYALIILSAMVS--------ITVAVYTSTRLV-PRRPNYV--ICLIGL 577
                            |.::::::..:.|        ||..|....||: .||..::  :|::..
  Rat   384 ----------------LFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIVSY 432

  Fly   578 VVAVISFAAPKFLIARVLDSRLVGTMVVTALV-FELIAITWIYGAKNIYTDLEFSIG-RPIFRVW 640
            ::.:.:.......:.::.|......|.:..|| ||.::|:|.||....|.:::..:| ||.  :|
  Rat   433 LIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPC--IW 495

  Fly   641 MWLWVIC-----PAILTGILVWWCADDDQYDLLAEYLPRWAP---ILFVLAVIVII 688
               |.:|     |.|:.|:.::.........:.:...|:|..   .|..|:.:|:|
  Rat   496 ---WKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLMALSSMVLI 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	115/504 (23%)
Slc6a1	NP_077347.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		2/9 (22%)
		SLC6sbd_GAT1	2..599	CDD:212075	128/576 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..599
		PDZ-binding	597..599
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810