DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment blot and Slc6a21

DIOPT Version :9

Sequence 1:	NP_524125.2	Gene:	blot / 39939	FlyBaseID:	FBgn0027660	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_006541333.1	Gene:	Slc6a21 / 76713	MGIID:	1923963	Length:	749	Species:	Mus musculus

Alignment Length:	763	Identity:	145/763 - (19%)
Similarity:	274/763 - (35%)	Gaps:	253/763 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 LVLCLCLNLSYANVVRFPRELDRY------GSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQGAA 280
            :::.:..::...:..|||     |      |.::|:.|.:||.|:|:|::.:|:.:||:|.....
Mouse    58 ILILVAFSIGLGSTWRFP-----YLCHQNGGGSFLLMYFILLLLLGIPLMYMEMVIGQWLRMDNI 117

  Fly   281 HTWR-ASPIFKG-------ACMI-----SRFASWLSAIWVSLQAVLALAYIGMFASNDLPFRECA 332
            ..|: ..|...|       ||::     |...||            :|.|:|......||::.|
Mouse   118 QAWKYLVPWLSGVGYSNILACVLVVLYNSALVSW------------SLFYLGQSFDYPLPWQNC- 169

  Fly   333 GPVKLRLSGYLLTGTSGQECLQLTFLTPFWRNP----LYFGLLAAG-----------------LI 376
             |:...||     ..:|..||        |..|    .|..||.|.                 |.
Mouse   170 -PLVENLS-----MVAGNTCL--------WSEPHQYFWYHTLLQASNQMEEGIEVLVLNVTLCLF 220

  Fly   377 GLWI---VVMLCTHNAKILRRSIFVFGLV--GLVLLC------TLTGWEVRNSFSRHYFPELWGF 430
            ..||   |.|:......:|   :.:|.::  .::|||      .|.| .||.|..|....||
Mouse   221 ATWIFLYVTMVTRIKISVL---MMIFSILFSNVLLLCFFIRTLFLNG-SVRASLWRLVTIEL--- 278

  Fly   431 DSNLLAESNIWFNALMQVLFSVNCGFGALPMIT-GKFLYKGD-----AVRTSVVYLCFNLLINAI 489
              ::|:..:.|..|...||:|:..|.|.:  || ..:..:|:     |...::|.|..:||.:.:
Mouse   279 --SILSSLDAWRQAGGHVLYSLGLGMGTI--ITFSTYQPRGENYIKWASFVAMVNLATSLLSSFV 339

  Fly   490 AVTLFMVQ-------------------FDLSSNGF------------------------------ 505
               :|:|.                   .:|.:||.
Mouse   340 ---IFLVMGFWTTTSGTMCIKRSVSNLINLIANGVLPKAAWPPGDIIHKPPLEYLAWINQLPNNL 401

  Fly   506 --QNMEELKPLTAIY--DRVLNG---SREGDSHLLQHLVPSLIYALI------------ILSAMV 551
              |.:.:..|.:.:.  ::::.|   |....|..:.....|..:|:|            :|:.:.
Mouse   402 KSQVIHQTLPCSILIQKEKIMEGPGLSYVAFSQAISLFPGSSFWAIIFFMSLAIMGLGTMLTLLE 466

  Fly   552 SITVAVYTSTRLVPRRPNYV---ICLIGLVVAVISFAAPKFLIARVLDSRLVGTMVVTALVFELI 613
            .|.:.:..|.....:.||.|   :||.|.:.:::..:.|...:..:.|..||..:::..:|.:.:
Mouse   467 GIVLPLQKSISTFAKHPNLVQVLVCLGGFLGSLVFSSRPGSYVVFLFDDLLVPMVLIIIVVIQNL 531

  Fly   614 AITWIYGAKNIYTDLEFSIGRPIFR--VWMWLWVICPAILTGILVW--------------WCADD 662
            ::.|:||.|....::...:|..::.  .::|.:|..|.:|..:.::              | .|.
Mouse   532 SLAWLYGIKRFRAEVFGQLGSLVWSPFTFLWSYVTLPTLLVLLTIYFLNLYYSGSPYYVSW-NDS 595

  Fly   663 DQYDLLAEY--LP-RWAPILFVLAVIVIIACVQIFRQVEYNFFGMICEASKPAKEWGPADPLARH 724
            ..:::...|  :| .|...|.|||::.|:.                    .|.:.|...|.
Mouse   596 MSHEVKQPYKKIPLGWVTFLSVLALLPILV--------------------YPLQHWWYLDD---- 636

  Fly   725 SWKQWRSVCQD-----TGRRDFTLRRRGTRDYTHSIKK----GQYSSATKYGVQNGGQTQTP--- 777
                 .::|:.     :.::..|:..|.|:...|.::|    .|..|...:      |:::|
Mouse   637 -----PNICETLEKPLSSKKTVTVPNRVTQWPVHPMRKLTLRNQEKSKALF------QSKSPPEN 690

  Fly   778 -MHQQHWKSSTPGNSSPNYSGSMFGDSAIEEDI--------SVDKFPG 816
             :|.|   :......|.|||.....|:.:...:        .|.|:.|
Mouse   691 FLHPQ---TLITKKDSENYSTFSLPDATLPSQVGFSTLAIHEVSKYTG 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	112/580 (19%)
Slc6a21	XP_006541333.1	SLC5-6-like_sbd	48..622	CDD:382020	121/610 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100