Protein Alignment blot and SLC6A13

DIOPT Version :9

• Sequence 1: NP_524125.2
• Gene: blot / 39939
• FlyBaseID: FBgn0027660
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_057699.2
• Gene: SLC6A13 / 6540
• HGNCID: 11046
• Length: 602
• Species: Homo sapiens
• Alignment Length: 650
• Identity: 143/650 - (22%)
• Similarity: 238/650 - (36%)
• Gaps: 194/650 - (29%)

  Fly   196 TASNAKLLPAVEDESNKQTKCSVFRG-------LVLCLCLN-LSYANVVRFPRELDRY------G 246
            |.||.:..|.......|:...::.||       .||.:... :...||.|||     |      |
Human     8 TTSNGETKPVYPVMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFP-----YLCYKNGG 67

  Fly   247 SAYLVPYVVLLFLVGLPMVLLEISVGQFLGQGAAHTWR-ASPIFKGACMISRFASWLSAIWVSLQ 310
            .|:.:||:|.||..|:|:.|||.::||:..||....|| ..|||:|.    .:||.:..|.:::.
Human    68 GAFFIPYLVFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGI----GYASQMIVILLNVY 128

  Fly   311 AVLALAY--IGMFAS--NDLPFRECAGP------VKLRLSGYLLTGTSGQECLQLTFLTPFWRNP 365
            .::.||:  ..:|:|  .|||:..|...      ::.:.:...|.|||..   ..:.:..||...
Human   129 YIIVLAWALFYLFSSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSEN---ATSPVIEFWERR 190

  Fly   366 L--------YFGL----LAAGLIGLWIVVMLCT-HNAKILRRSIF---VFGLVGLVLL----CTL 410
            :        :.|.    ||..|:..|::...|. ...|...:.::   .|..:.||:|    .||
Human   191 VLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTL 255

  Fly   411 TGWEVRNSFSRHYFPELWGFDSNLLAESNIWFNALMQVLFSVNCGFGALPMITGKFLYKGDAVRT 475
            .|  .......:.:|.|     ..|.:..:|.:|..|:.||.....|.|..:.....|..:..|.
Human   256 PG--AAQGIQFYLYPNL-----TRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRD 313

  Fly   476 SVVYLCFNLLINAIAVTLFMVQFDL-SSNGFQNMEELKPLTAIYDRVLNGSREGDSHLLQHLVPS 539
            .:. |||   :|  :.|.|:..|.: |..||.:.|:..|::.:       :..|         |.
Human   314 CIA-LCF---LN--SGTSFVAGFAIFSILGFMSQEQGVPISEV-------AESG---------PG 356

  Fly   540 LIYALIILSAMVSITVAVYTSTRLVPRRPNYVICLIGLVVAV---ISFAAPKFLIARVLD----- 596
            |.:            :|...:..::|..|.:..|...:||.:   ..|...:.|:..::|
Human   357 LAF------------IAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHV 409

  Fly   597 -----------------SRLVGTMVVT----------------------ALVFELIAITWIYGAK 622
                             |.|||.:::|                      ..:||.:.:.|:||||
Human   410 FRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAK 474

  Fly   623 NIYTDLEFSIGRPIFRVW-----MWLWVICPAILTGILVWWCADDDQYDLLAEYLPR-------- 674
            ..|.::|..||   :|.|     .||: :.||:.|...::         .|.:|.|.
Human   475 RFYDNIEDMIG---YRPWPLIKYCWLF-LTPAVCTATFLF---------SLIKYTPLTYNKKYTY 526

  Fly   675 --WAPILFVLAVIVIIACVQI------------FRQVEYNFFGMICEAS-----KPAKEWGPADP 720
              |...|..|..:..:.|:..            ||:   ....::|.|.     .||....||.|
Human   527 PWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRE---RIRQLMCPAEDLPQRNPAGPSAPATP 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	122/537 (23%)
SLC6A13	NP_057699.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		4/13 (31%)
		SLC6sbd_GAT2	32..575	CDD:271396	133/611 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810