Protein Alignment blot and SLC6A12

DIOPT Version :10

• Sequence 1: NP_524125.2
• Gene: blot / 39939
• FlyBaseID: FBgn0027660
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_003035.3
• Gene: SLC6A12 / 6539
• HGNCID: 11045
• Length: 614
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 123/547 - (22%)
• Similarity: 216/547 - (39%)
• Gaps: 129/547 - (23%)

  Fly   230 LSYANVVRFPRELDRY------GSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQGAAHTWR-ASP 287
            :...||.|||     |      |.|:.:||.:..|:.|:|:..||:::||:..||:...|| ..|
Human    54 IGLGNVWRFP-----YLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICP 113

  Fly   288 IFKGACMIS-RFASWLSAIWVSLQAVLALAYIGMFAS--NDLPFRECAGPVKL-RLSGYLLTGTS 348
            :|:|..:.| ...|:|:..::   .:||.|...:|:|  ::||:..|...... ..:.:|....:
Human   114 LFQGIGLASVVIESYLNVYYI---IILAWALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGA 175

  Fly   349 GQECLQLTFLTP---FWRNPLYFGL-------------LAAGLIGLWIVVMLCT-HNAKILRRSI 396
            |.......|.:|   ||...: .|:             ||..|:..|::...|. ...|...:.:
Human   176 GTVTPFENFTSPVMEFWERRV-LGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVV 239

  Fly   397 F---VFGLVGLVLL----CTLTGWEVRNSFSRHYFPELWGFDSNLLAESNIWFNALMQVLFSVNC 454
            :   .|..:.||:|    .||.|  .......:..|:|:     .|.:..:|.:|..|:.||...
Human   240 YFTATFPYLMLVILLIRGVTLPG--AYQGIIYYLKPDLF-----RLKDPQVWMDAGTQIFFSFAI 297

  Fly   455 GFGALPMITGKFLYKGDAVRTSVVYLCFNLLINAIAVTLFMVQFDL-SSNGFQNMEELKPLTAIY 518
            ..|.|..:.....|..:..:..:. |||   :|  :.|.|:..|.: |..||.:.|:..|::.:.
Human   298 CQGCLTALGSYNKYHNNCYKDCIA-LCF---LN--SATSFVAGFVVFSILGFMSQEQGVPISEVA 356

  Fly   519 DRVLNGSREGDSHL----------LQHLVPSLIYALIIL----SAMVSITVAVYTSTRLVPR--R 567
            :     |..|.:.:          |..|...|.:.::|.    |..|.:...|..|..:.||  |
Human   357 E-----SGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLR 416

  Fly   568 PNYVICLIGLVVAVISFAAPKFLIARVLDSRLVGTMVVTAL---------------VFELIAITW 617
            .:....|:.|.:||:.:....||:..       |.|.:..|               :||::.|:|
Human   417 KSGRRELLILTIAVMCYLIGLFLVTE-------GGMYIFQLFDYYASSGICLLFLSLFEVVCISW 474

  Fly   618 IYGAKNIYTDLEFSIGRPIFRVW-----MWLWVICPAILTGILVWWCADDDQYDLLAEY------ 671
            :|||...|.::|..||   :|.|     .||: :.|.:.....::         .|::|
Human   475 VYGADRFYDNIEDMIG---YRPWPLVKISWLF-LTPGLCLATFLF---------SLSKYTPLKYN 526

  Fly   672 ----LPRWAPILFVLAVIVIIACVQIF 694
                .|.|...:.....:..:.||.:|
Human   527 NVYVYPPWGYSIGWFLALSSMVCVPLF 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	116/500 (23%)
SLC6A12	NP_003035.3	SLC6sbd_BGT1	35..575	CDD:212080	123/547 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	576..614