DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment blot and SLC6A9

DIOPT Version :9

Sequence 1:	NP_524125.2	Gene:	blot / 39939	FlyBaseID:	FBgn0027660	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_964012.2	Gene:	SLC6A9 / 6536	HGNCID:	11056	Length:	706	Species:	Homo sapiens

Alignment Length:	820	Identity:	182/820 - (22%)
Similarity:	299/820 - (36%)	Gaps:	268/820 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 SGGG--------RTTATSGRISSSGIVTLSDSNNTLSEIQGGYHDMDHDAVSKNFSISASAHNI- 194
            |||.        |..|..|.::.|     |....||..:|..:........:.:.|::.|...:
Human     2 SGGDTRAAIARPRMAAAHGPVAPS-----SPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKVW 61

  Fly   195 TTASNAKLLP--------------AVEDESNKQTKCSVFRG----LVLCLCLNLSYA----NVVR 237
            ..|.|:.|||              ||..|:.|:.: ::.||    .:..:..::.||    ||.|
Human    62 HGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQ-NLKRGNWGNQIEFVLTSVGYAVGLGNVWR 125

  Fly   238 FPRELDRY-GSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQGAAHTWRASPIFKGA----CMISR 297
            ||....|. |.|::.||.::|...|:|:..:|:|.|||..||....||.||:|||.    .::|.
Human   126 FPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVST 190

  Fly   298 FASWLSAIWVSLQAVLALAYIGMFAS--NDLPF---------RECAG------------PVKL-- 337
            :      |.:....|:.:|:...|:|  :.||:         .:|||            |..|
Human   191 Y------IGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPS 249

  Fly   338 ---RLSGYLLTGTSGQECLQLTFLTPFWRNPLY----------FGLLAAGLIGL----WIVVMLC 385
               .|..:.|..||..|        .:||  ||          ||.:...|:|.    |:||.||
Human   250 NLSHLLNHSLQRTSPSE--------EYWR--LYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLC 304

  Fly   386 -THNAKILRRSIFVFGLVGLVLLCTL--TGWEVRNSFS--RHYFPELWGFDSNLLAESNIWFNAL 445
             ....|...:.::.......|:|..|  .|..:..:|.  .:|....|    :.:.|:.:|.:|.
Human   305 LIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQW----DKILEAKVWGDAA 365

  Fly   446 MQVLFSVNCGFGALPMITGKFLYKGDAVRTSVV-------------YLCFNLL------------ 485
            .|:.:|:.|.:|.|..:.....:..:..|.||:             ::.|::|
Human   366 SQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVS 430

  Fly   486 ----------------------INAIAVTLFMVQFDLSSNG--FQNMEELKPLTAIYDRVLNGSR 526
                                  |:.:...||.....|...|  |..:|.|  :|||.|.|
Human   431 RVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETL--VTAIVDEV----- 488

  Fly   527 EGDSHLLQHLVPSLIYALIILSAMVSITVAVYTSTRLVPRRPNYVICLIGLVVAVISFAAPKFLI 591
             |:..:||.            ...|::.|||             ...|:|  :.:.|.|...:|:
Human   489 -GNEWILQK------------KTYVTLGVAV-------------AGFLLG--IPLTSQAGIYWLL 525

  Fly   592 ARVLDSRLVGTMVVTALVFELIAITWIYGAKNIYTDLEFSIG--RPIFRVWMWLWVICPAILTGI 654
              ::|:......:|.......:||.:|||.:|.:.|::..:|  .|:|....|.:| .|||:..|
Human   526 --LMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFV-SPAIIFFI 587

  Fly   655 LVWWCADDDQYDLLA----EYLPRWAPILFVLAVIVIIACVQIFRQVEYNFFGMIC--------- 706
            ||:...   ||..:.    :| |.||..:..|..:..:.|:.::....      :|
Human   588 LVFTVI---QYQPITYNHYQY-PGWAVAIGFLMALSSVLCIPLYAMFR------LCRTDGDTLLQ 642

  Fly   707 ---EASKPAKEWGPADPLARHSWKQWRSVCQDTGRRDFTLRRRGTRDYTHSIKKGQYSSATKYGV 768
               .|:||:::||||  |..|                               :.|:|:.......
Human   643 RLKNATKPSRDWGPA--LLEH-------------------------------RTGRYAPTIAPSP 674

  Fly   769 QNGGQTQTPMHQQHWKSSTP---GNSSPNYSGSMFGDSAI 805
            ::|.:.| |:|..  |:..|   .|.|     |...||.|
Human   675 EDGFEVQ-PLHPD--KAQIPIVGSNGS-----SRLQDSRI 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	128/550 (23%)
SLC6A9	NP_964012.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		7/28 (25%)
SLC6A9	NP_964012.2	SLC6sbd_GlyT1	84..667	CDD:212067	151/684 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810