Protein Alignment blot and SLC6A7

DIOPT Version :9

• Sequence 1: NP_524125.2
• Gene: blot / 39939
• FlyBaseID: FBgn0027660
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: XP_016865256.1
• Gene: SLC6A7 / 6534
• HGNCID: 11054
• Length: 754
• Species: Homo sapiens
• Alignment Length: 752
• Identity: 166/752 - (22%)
• Similarity: 297/752 - (39%)
• Gaps: 194/752 - (25%)

  Fly    95 RRQPQRM-SWLNMRRAKANETDLPTVTPSPQTTRSCISTVSSVVDSGGGRTTATSGRISSSGIVT 158
            ||..|.: |.|....|::.:|..|...|:|...|.......|     |.||.:.:..:.:.|.::
Human    15 RRDRQGIRSALPALHARSRQTAAPASVPAPAGAREPRGQRRS-----GQRTISRALALCAPGQLS 74

  Fly   159 LSDSNNTLSEIQGGYHDMDHDAVSKNFSISASAH-NITTASNAKLLPAVEDESNKQTKCSVFRG- 221
            .....:.:.::||                   || ......:..:.|:.:.:.:.....:..||
Human    75 PGHPLSKMKKLQG-------------------AHLRKPVTPDLLMTPSDQGDVDLDVDFAAHRGN 120

  Fly   222 -------LVLCLCLNLSYANVVRFP-RELDRYGSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQG 278
                   |:.|:...:...||.||| |.....|.|:||||.::|.:.|:|:..||:|:|||...|
Human   121 WTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLG 185

  Fly   279 AAHTWRASPIFKGACMISRFASWLSAIWVSLQAVLALAYIGMFASNDLPFRECAG--PVKLRLSG 341
            ....|:.||:||||.........|.||:.::.....|.|:....::|||:..|..  ..:|.|..
Human   186 PLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEH 250

  Fly   342 YLLTGTSGQECLQLT-FLTP---FW--------------------------------------RN 364
            .:....:|...|.|| .::|   :|                                      |.
Human   251 RVSKDGNGALPLNLTCTVSPSEEYWSQTHTEAEEEGRRGRVVSNSYPQVIFLPQPPKAEEGVSRY 315

  Fly   365 PLYF----GLLAAG---------LIGLWIVVMLC-----THNAKILRRSIFVFGLVGLVLL---C 408
            .|:.    |:.:.|         |:..|::|.||     ..:.|::..:.....|:.|:||   .
Human   316 VLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGV 380

  Fly   409 TLTG-WEVRNSFSRHYFPELWGFDSNLLAESNIWFNALMQVLFSVNCGFGALPMITGKFLYKGDA 472
            ||.| |:   ....:..|:.     :.|..|.:|..|.:|:.:|:..|||.|........:..:.
Human   381 TLPGAWK---GIQFYLTPQF-----HHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNI 437

  Fly   473 VRTSVVYLCFNLLINAIAVTLFMVQFDL-SSNGFQNMEELKPLT-----------AIYDRVLNGS 525
            .|.:.:....|      |:|..:..|.: |..|:.:.|...|:.           .:|.:.:.
Human   438 YRDTFIVTLGN------AITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQAMT-- 494

  Fly   526 REGDSHLLQHLVP--SLIYALIILS-------AMVSITVAVYTST---RLVPRRPNY--VIC--- 573
                   :..|.|  |.::..::|:       |.:...|...|..   .|.|::..:  :||
Human   495 -------MLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAM 552

  Fly   574 -LIGLVVAVISFAAPKFLIARVLD--SRLVGTMVVTALVFELIAITWIYGAKNIYTDLEFSIG-R 634
             |:||::.  :.....:|:  :||  |...|.|||  ::...:|:|.:||.:....|:...:| :
Human   553 YLMGLILT--TDGGMYWLV--LLDDYSASFGLMVV--VITTCLAVTRVYGIQRFCRDIHMMLGFK 611

  Fly   635 P--IFRVWMWLWVICPAILTGILVWWCADDDQYDLL----AEY----LPRWAPILFVLAVIVIIA 689
            |  .||. .||: :.||.|..::|        |.::    :||    .|.||.:|.:|  :.:::
Human   612 PGLYFRA-CWLF-LSPATLLALMV--------YSIVKYQPSEYGSYRFPPWAELLGIL--MGLLS 664

  Fly   690 C--------VQIFRQVEYNFFGMICEASKPAKEWGPA 718
            |        |.:.|: |.:.:..:.:||:||.:|||:
Human   665 CLMIPAGMLVAVLRE-EGSLWERLQQASRPAMDWGPS 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	126/549 (23%)
SLC6A7	XP_016865256.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810