DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment blot and SLC6A6

DIOPT Version :9

Sequence 1:	NP_524125.2	Gene:	blot / 39939	FlyBaseID:	FBgn0027660	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001127839.2	Gene:	SLC6A6 / 6533	HGNCID:	11052	Length:	721	Species:	Homo sapiens

Alignment Length:	562	Identity:	132/562 - (23%)
Similarity:	213/562 - (37%)	Gaps:	163/562 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 NVVRFPRELDRY------GSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQGAAHTW-RASPIFKG 291
            ||.|||     |      |.|:|:||.:.||..|||:..|||.:||:..:|....| :..|:|.|
Human   164 NVWRFP-----YLCYKNGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSG 223

  Fly   292 ACMISRFASWLSAIWVSLQ-----AVLALAYIGMFAS--NDLPFREC----------AGPVKLRL 339
                   ..:.|.:.|||.     .:||.|...:|.|  .:||:..|          ...::...
Human   224 -------IGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNK 281

  Fly   340 SGYLLTGTSGQECLQLTFLTP---FW-RNPLYF--GL---------LAAGLIGLWIVVMLC---- 385
            |.::...::       .|.:|   || ||.|..  |:         ||..|:.:|:|...|
Human   282 SVWITISST-------NFTSPVIEFWERNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKG 339

  Fly   386 -THNAKILR-RSIFVFGLVGLVLL---CTLTGWEVRNSFSRHYFPELWGFDSNLLAESNIWFNAL 445
             ....|::. .:.|.|.:: ||||   .||.|......|  :.:|     |...|.:..:|.:|.
Human   340 VRSTGKVVYFTATFPFAML-LVLLVRGLTLPGAGAGIKF--YLYP-----DITRLEDPQVWIDAG 396

  Fly   446 MQVLFSVNCGFGALPMITGKFLYKGDAVRTSVVYLCFN---LLINAIAVTL---FMVQ------F 498
            .|:.||.....||:..:.....||.::.|..::..|.|   ..::..|:..   ||.|      .
Human   397 TQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIA 461

  Fly   499 DLSSNG-------FQNMEELKPLTAIYDRVLNGSREGDSHLLQHLVPSLIYALIIL-----SAMV 551
            |::.:|       :.....:.||...:                    |:::.:::|     |..|
Human   462 DVAESGPGLAFIAYPKAVTMMPLPTFW--------------------SILFFIMLLLLGLDSQFV 506

  Fly   552 SITVAVYTSTRLVP-------RRPNYV--ICLIGLVVAVISFAAPKFLIARVLDSRLV-GTMVVT 606
            .:...:.:...|.|       ||..::  :|.|..::.:.........:.::.|.... |..::.
Human   507 EVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLW 571

  Fly   607 ALVFELIAITWIYGAKNIYTDLEFSIG-RPIFRVWM-WLW-VICPAILTGILVWWCADDDQYDLL 668
            ...||...|.||||..|:|..:|..|| ||  ..|| :.| ||.|.:..|..::         .|
Human   572 VAFFECFVIAWIYGGDNLYDGIEDMIGYRP--GPWMKYSWAVITPVLCVGCFIF---------SL 625

  Fly   669 AEYL----------PRWA----------PILFVLAVIVIIAC 690
            .:|:          |.||          .:|.|..||||..|
Human   626 VKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLC 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	120/509 (24%)
SLC6A6	NP_001127839.2	SLC6sbd_TauT	142..683	CDD:271398	132/562 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810