Protein Alignment blot and SLC6A3

DIOPT Version :9

• Sequence 1: NP_524125.2
• Gene: blot / 39939
• FlyBaseID: FBgn0027660
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_001035.1
• Gene: SLC6A3 / 6531
• HGNCID: 11049
• Length: 620
• Species: Homo sapiens
• Alignment Length: 652
• Identity: 133/652 - (20%)
• Similarity: 233/652 - (35%)
• Gaps: 183/652 - (28%)

  Fly   195 TTASNAKLLPAVEDESNKQTKCSVFRGLVLCLCLNLSYANVVRFPRELDRY------GSAYLVPY 253
            :|.:|.:..|.  :..:::|.......|:..:...:..|||.|||     |      |.|:||||
Human    45 STLTNPRQSPV--EAQDRETWGKKIDFLLSVIGFAVDLANVWRFP-----YLCYKNGGGAFLVPY 102

  Fly   254 VVLLFLVGLPMVLLEISVGQFLGQGAAHTWRASPIFKGACMISRFASWLSAIWVSL--QAVLALA 316
            ::.:.:.|:|:..:|:::|||..:|||..|:..||.||.    .|...|.:::|..  ..::|.|
Human   103 LLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILKGV----GFTVILISLYVGFFYNVIIAWA 163

  Fly   317 YIGMFAS--NDLPFREC------------------------------------------------ 331
            ...:|:|  .:||:..|
Human   164 LHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSH 228

  Fly   332 ----AGPVKLRLSGYLLTGTSGQECLQLTFLTPFWRNPLYF----GLLAAGLIGLWIVVML--CT 386
                .||.:.:|:.          ||.|..:.      |||    |:..:|.: :||...:  ..
Human   229 GIDDLGPPRWQLTA----------CLVLVIVL------LYFSLWKGVKTSGKV-VWITATMPYVV 276

  Fly   387 HNAKILRRSIFVFGLVGLVLLCTLTGWEVRNSFSRHYFPELWGFDSNLLAESNIWFNALMQVLFS 451
            ..|.:||         |:.|...:.|  :|...|..::         .|.|:::|.:|..||.||
Human   277 LTALLLR---------GVTLPGAIDG--IRAYLSVDFY---------RLCEASVWIDAATQVCFS 321

  Fly   452 VNCGFGALPMITGKFLYKGDAVRTSVVYLCFNLLINAIAVTLFMVQFDL-SSNGFQNMEELKPLT 515
            :..|||.|...:....:..:..|.::|....|      ::|.|...|.: |..|:...:...|:.
Human   322 LGVGFGVLIAFSSYNKFTNNCYRDAIVTTSIN------SLTSFSSGFVVFSFLGYMAQKHSVPIG 380

  Fly   516 AIYDRVLNGSREGDSHLLQHLVPSLIYALIILSA--------------------MVSITVAVYTS 560
            .:       :::|.. |:..:.|..|..|.:.||                    |.|:...:...
Human   381 DV-------AKDGPG-LIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDE 437

  Fly   561 TRLVPRRPNYVICLIGLVVAVISFAAPKFLIAR-------VLDSRLVGTMVVTALVFELIAITWI 618
            .:|:.|...    |..|.:.:.:|....|.:..       :||....||.::..::.|.|.:.|.
Human   438 FQLLHRHRE----LFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWF 498

  Fly   619 YGAKNIYTDLEFSIGRPIFRVWMWLW-VICPAILTGILVWWCADDDQYDLLAEYLPRWAPILFVL 682
            ||......|::...|:.....|...| ::.|..|..::|............|...|.||..|..:
Human   499 YGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWV 563

  Fly   683 AVIVIIACVQIFRQVEY-----NFFGMICEASKPAKEWGPADPLARHSWKQWRSVCQDTGRRDFT 742
            .....:|.|.|:...::     :|...:..|..|.|:               |.:......|.||
Human   564 IATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD---------------RELVDRGEVRQFT 613

  Fly   743 LR 744
            ||
Human   614 LR 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	111/536 (21%)
SLC6A3	NP_001035.1	SLC6sbd_DAT1	60..614	CDD:212083	127/632 (20%)
		Interaction with TGFB1I1. /evidence=ECO:0000269|PubMed:12177201	561..590		4/28 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810