Protein Alignment blot and SLC6A1

DIOPT Version :10

• Sequence 1: NP_524125.2
• Gene: blot / 39939
• FlyBaseID: FBgn0027660
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_003033.3
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Alignment Length: 600
• Identity: 134/600 - (22%)
• Similarity: 242/600 - (40%)
• Gaps: 115/600 - (19%)

  Fly   201 KLLPAVEDESNKQTKCSVFRGLVLCLCLNLSYANVVRFPRELDRY-GSAYLVPYVVLLFLVGLPM 264
            |:.....|..::.|....|..|:.|:...:...||.|||....:. |.|:|:||.:.|...|:|:
Human    33 KVQKKAADLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPL 97

  Fly   265 VLLEISVGQFLGQGAAHTWRASPIFKGACMISRFAS-WLSAIWVSLQAVLALAYIGMFASNDLPF 328
            .|||.|:||:...|....|:.:|:|||..:.:...| ||:..::.:.: .|:.|:....:..||:
Human    98 FLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIIS-WAIYYLYNSFTTTLPW 161

  Fly   329 RECAGP--VKLRLSGYLLTGTSGQECLQLTFLTPFWRNPLY---FGL---------LAAGLIGLW 379
            ::|..|  .....|.|.:..|:.    ..:.:..||...::   .||         ||..|...|
Human   162 KQCDNPWNTDRCFSNYSMVNTTN----MTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAW 222

  Fly   380 IVVMLCT-----HNAKILRRSIFVFGLVGLVLL----CTLTGWEVRNSFSRHYFPELWGFDSNLL 435
            |:|..|.     ...|::..|. .:..:.|::|    .||.|  .:.....:..|..     ..|
Human   223 ILVYFCIWKGVGWTGKVVYFSA-TYPYIMLIILFFRGVTLPG--AKEGILFYITPNF-----RKL 279

  Fly   436 AESNIWFNALMQVLFSVNCGFGALPMITGKFLYKGDAVRTSVVYLCFNLLINAIA--VTLFMVQF 498
            ::|.:|.:|..|:.||...|.|:|..:.....:..:..|.|::..|.|...:..|  |...:|.|
Human   280 SDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGF 344

  Fly   499 ----------DLSSNG----FQNMEE------LKPLTAIYDRVLNGSREGDSHLLQHLVPSLIYA 543
                      |::::|    |....|      :.||.||                      |.::
Human   345 MAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAI----------------------LFFS 387

  Fly   544 LIILSAMVS--------ITVAVYTSTRLV-PRRPNYV--ICLIGLVVAVISFAAPKFLIARVLDS 597
            ::::..:.|        ||..|....||: .||..::  :|:|..::.:.:.......:.::.|.
Human   388 MLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDY 452

  Fly   598 RLVGTMVVTALV-FELIAITWIYGAKNIYTDLEFSIG-RPIFRVWMWLWVIC-----PAILTGIL 655
            .....|.:..|| ||.::|:|.||....|.:::..:| ||.  :|   |.:|     |.|:.|:.
Human   453 YSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPC--IW---WKLCWSFFTPIIVAGVF 512

  Fly   656 VWWCADDDQYDLLAEYLPRWAP---ILFVLAVIVIIA--CVQIFRQVEYNFFGMICEASKPAK-- 713
            ::.........:.....|:|..   .|..|:.:|:|.  ...:|..::.:....|....:|::
Human   513 IFSAVQMTPLTMGNYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQPSEDI 577

  Fly   714 ---EWGPADPLARHS 725
               |.||..|.|..|
Human   578 VRPENGPEQPQAGSS 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	116/504 (23%)
SLC6A1	NP_003033.3	SLC6sbd_GAT1	2..599	CDD:212075	133/599 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		5/15 (33%)
		PDZ-binding	597..599