DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment blot and slc6a6b

DIOPT Version :9

Sequence 1:	NP_524125.2	Gene:	blot / 39939	FlyBaseID:	FBgn0027660	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001032750.1	Gene:	slc6a6b / 569098	ZFINID:	ZDB-GENE-030131-3077	Length:	625	Species:	Danio rerio

Alignment Length:	560	Identity:	127/560 - (22%)
Similarity:	214/560 - (38%)	Gaps:	156/560 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 NVVRFPRELDRY------GSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQGAAHTW-RASPIFKG 291
            ||.|||     |      |.|:|:||.:.||..|||:..||:::|||..:|....| :..|||.|
Zfish    63 NVWRFP-----YLCYKNGGGAFLIPYFIFLFGGGLPVFFLEVALGQFTSEGGITCWEKLCPIFTG 122

  Fly   292 ACMISRFASWLSAIWVSLQ-----AVLA--LAYIGMFASNDLPFRECAGPVKLRLSGYLLTGTSG 349
                   ..:.|.:.|||.     .:||  |.|:......:||:..|...            .:.
Zfish   123 -------IGYASIVIVSLLNIYYIVILAWGLYYLFQCFQPELPWASCNNK------------WNT 168

  Fly   350 QECLQLTF------------------LTPFW-RNPLYF--GL---------LAAGLIGLWIVVML 384
            :.|::.|.                  :|.|| ||.|..  |:         ||..|:.:|::...
Zfish   169 ENCVEDTLRRNKTLWAAANATNFTSPVTEFWERNVLSISDGIEEVGHVKWDLALCLLAMWVICFF 233

  Fly   385 CT-HNAKILRRSIFV---FGLVGLVLL----CTLTGWEVRNSFSRHYFPELWGFDSNLLAESNIW 441
            |. ...|...:.::|   |..|.|::|    .||.|  .......:.:|.:     ..|.:..:|
Zfish   234 CVWKGVKSTGKVVYVTATFPFVMLIVLLVRGVTLPG--AAEGIKFYLYPNV-----TRLGDPEVW 291

  Fly   442 FNALMQVLFSVNCGFGALPMITGKFLYKGDAVRTSVVYLCFN--LLINAI-AVTLFMVQFDL-SS 502
            .:|..|:.||.....||:..:.....||         |.|:.  ||:..: :.|.|:..|.: |.
Zfish   292 IDAGTQIFFSYAICLGAMTSLGSYNKYK---------YNCYRDCLLLGGLNSATSFVSGFAIFSV 347

  Fly   503 NGFQNMEELKPLTAI-----------YDRVLNGSREGDSHLLQHLVP------SLIYALIILSAM 550
            .||...|:...:..:           |.:.:.            ::|      .|.:.:::|..:
Zfish   348 LGFMAQEQGVDIADVAESGPGLAFIAYPKAVT------------MMPLPTFWAILFFIMLLLLGL 400

  Fly   551 VSITVAVYTS-TRLVPRRPNY------------VICLIGLVVAVISFAAPKFLIARVLDSRLV-G 601
            .|..|.|... |.||...|::            ::|.:..::.:.........:.::.|.... |
Zfish   401 DSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAIVCFVSYLLGLTMVTEGGMYVFQLFDYYAASG 465

  Fly   602 TMVVTALVFELIAITWIYGAKNIYTDLEFSIG-RPIFRVWM-WLW-VICPAILTGILVWWCAD-- 661
            ..::....||.||:.|:|||.|.|..:|..|| ||  ..|| |.| |:.|.:..|..::....
Zfish   466 VCLLWVAFFECIAVAWVYGADNFYDAIEEMIGYRP--NPWMKWSWTVVTPFLCVGCFIFSLVKYA 528

  Fly   662 DDQYDLLAEYLPRWA---------PILFVLAVIVIIACVQ 692
            ..:|:.:.|| |.|:         ..:..:.::|:|..:|
Zfish   529 PLRYNKIYEY-PDWSIGVGWTLALASMICIPMVVVIKIIQ 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	119/514 (23%)
slc6a6b	NP_001032750.1	SLC6sbd_TauT	41..582	CDD:271398	127/560 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910