DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment blot and slc6a8

DIOPT Version :9

Sequence 1:	NP_524125.2	Gene:	blot / 39939	FlyBaseID:	FBgn0027660	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001314797.1	Gene:	slc6a8 / 567544	ZFINID:	ZDB-GENE-071024-2	Length:	652	Species:	Danio rerio

Alignment Length:	570	Identity:	126/570 - (22%)
Similarity:	220/570 - (38%)	Gaps:	150/570 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 LVLCLCLNLSYANVVRFPRELDRY------GSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQGAA 280
            ::.|:...:...||.|||     |      |..:|:|||:.:||.|:|:..|||::|||:..|:.
Zfish    74 IMSCVGFAVGLGNVWRFP-----YLCYKNGGGVFLIPYVLFIFLGGIPIFFLEIALGQFMKAGSI 133

  Fly   281 HTWRASPIFKGACMISRFASWLSAIWVSLQAVLALA-----YIGMFASNDLPFRECAGP------ 334
            :.|..:|:|||.    .:||.:...:.:...::.||     :|..|.:. ||:..|..|
Zfish   134 NVWNIAPLFKGL----GYASMVIVFFCNTYYIMVLAWGFYYFIKSFNAT-LPWSTCDNPWNTENC 193

  Fly   335 VKLRLSGYLLTGTSGQE------CLQL----TFLTPFWRNP---LYFGLLAAG---------LIG 377
            :::...|....||.|..      |.:|    :.:..||.|.   :..||...|         |:.
Zfish   194 IEIFRQGDCKNGTIGNSTFGNLTCEELANGRSPIIEFWENKVLNISDGLDEPGAVNWELMLCLLA 258

  Fly   378 LWIVVMLCT-HNAKILRRSIF---VFGLVGLVLL----CTLTG------WEVRNSFSRHYFPELW 428
            :|::|..|. ...|...:.::   .|..|.|::|    .||.|      :.|:..:|:
Zfish   259 VWVMVYFCVWKGVKSTGKIVYFTATFPYVVLIILLVRGVTLPGAYDGILYYVKPDWSK------- 316

  Fly   429 GFDSNLLAESNIWFNALMQVLFSVNCGFGALPMITGKFLYKGDAVRTSVVYLCFNLLINAIA--V 491
                  |.|:.:|.:|..|:.||...|.|||..:.....:..|..:.:.|....|...:..|  |
Zfish   317 ------LGEAQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNDCYKDAFVLALINSGTSFFAGFV 375

  Fly   492 TLFMVQFDLSSNG--FQNMEELKPLTAI--YDRVLNGSREGDSHLLQHLVP---SLIYALIILSA 549
            ...::.|..|..|  ...:.|..|..|.  |.:.::         :..:.|   :|.:.:::|..
Zfish   376 VFSILGFMASEQGVDISKVAESGPGLAFIAYPKAVS---------MMPVAPVWAALFFIMLLLLG 431

  Fly   550 MVSITVAVYTSTRLVPRRPNYVICLIGLVVAVISFAAPKF--------------LIARVLDSRLV 600
            :.|..|.|.                 |.|..::.....|:              |:..::|..:|
Zfish   432 LDSQFVGVE-----------------GFVTGILDLFPGKYYMRYQREIAVAICCLLCFIIDLSMV 479

  Fly   601 --GTMVVTAL---------------VFELIAITWIYGAKNIYTDLEFSIG-RPIFRVWM-WLW-V 645
              |.|.|..|               .:|.:.:.|:|||.....|:...|| ||.  .|| |.| :
Zfish   480 TQGGMYVFQLFDYYSASGMTLLWQAFWECVVVAWVYGADRFMDDIARMIGYRPF--PWMKWCWSI 542

  Fly   646 ICPAILTGILVWWCADDD--QYDLLAEYLPRWAPILFVLAVIVIIACVQI 693
            |.|.:..||.::...:..  .|:.:..| |.|..::.....:..:.|:.:
Zfish   543 ITPCVCMGIFLFHLLNYKPLTYNNVYVY-PWWGEVIGWCLALSSMLCIPV 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	121/532 (23%)
slc6a8	NP_001314797.1	SLC6sbd_CT1	64..652	CDD:271397	126/570 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810