DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment blot and si:ch211-132b12.6

DIOPT Version :9

Sequence 1:	NP_524125.2	Gene:	blot / 39939	FlyBaseID:	FBgn0027660	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001038523.1	Gene:	si:ch211-132b12.6 / 564583	ZFINID:	ZDB-GENE-050420-179	Length:	577	Species:	Danio rerio

Alignment Length:	532	Identity:	126/532 - (23%)
Similarity:	202/532 - (37%)	Gaps:	124/532 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 NVVRFPRELDRY-GSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQGAAHTW-RASPIFKGACMIS 296
            ||.|||....|. |..:|:||:|.:...|||:.|||.::|||..:|....| |..|:.:|.....
Zfish    33 NVWRFPYLCYRNGGGVFLIPYLVFVVTCGLPLFLLETAMGQFTHEGGITCWHRLCPLAQGVGYAG 97

  Fly   297 RFASWLSAIWVSLQAVLALAYIGMFASNDLPFREC-------------AGPVKLRLSGYLLTGTS 348
            :.....|.::.::....||.|:....|:.||:..|             ||.:....: .|...||
Zfish    98 QLTVLYSCMYYTIILAWALFYLVSSFSSQLPWVSCNNIWNTDNCVNLAAGNLTFNRT-TLANSTS 161

  Fly   349 GQECLQLTFLTPFWRN---PLYFGLLAAG---------LIGLWIVVMLC-----THNAKILRRSI 396
            .        .|.||..   .|..|:...|         ||.:||:...|     ....|::..:.
Zfish   162 A--------ATEFWERRVLSLSGGIEDIGKINWEILLCLIAMWIICYFCIWKGVKSTGKVVYFTA 218

  Fly   397 ---FVFGLVGLVLLCTLTGWEVRNSFSRHYFPELWGFDSNLLAESNIWFNALMQVLFSVNCGFGA 458
               :|..||.|:...||.|  .......:.:||     ...||:..:|..|..||.||.:...|.
Zfish   219 TFPYVMLLVLLIRGLTLPG--ALQGVVFYLYPE-----PARLADPQVWMEAGTQVFFSYSVCSGI 276

  Fly   459 LPMITGKFLYKGDAVRTSVVYLCFNLLINAIAVTLFMVQFDL-SSNGFQNMEELKPLTAIYDRVL 522
            |..:.....|..:..|.| .:||   |:|  :.|.|:..|.: |..||....:..|:..:.:
Zfish   277 LISLGSYNQYSNNCYRDS-FWLC---LLN--SGTSFVAGFAVFSVLGFMAHVQGVPVEEVAE--- 332

  Fly   523 NGSREGDSHL----------LQHLVPSLIYALIIL----SAMVSITVAVYTSTRLVP-------R 566
              |..|.:.:          ...|.....:.:|||    |..|.|...:.:...|.|       |
Zfish   333 --SGPGLAFIAYPQAMAMMPFPQLWAVCFFIMIILLGLDSQFVGIECVITSVMDLFPEVLRRAGR 395

  Fly   567 RPNYVI-----CLIGLVVAVISFAAPKFLIARVLDSRLV-GTMVVTALVFELIAITWIYGAKNIY 625
            |..:|:     |..|.::.|....   ..:.::.|:... |..::...|||.:||.|::||:.::
Zfish   396 RELFVLLLCLTCFFGQLIMVTEGG---MYVFQLFDNYACNGACLLFLSVFESLAIGWLFGAEKMF 457

  Fly   626 TDLE-FSIGRPIFRVWMWLWVICPAILTGILV------------------WWCADDDQYDL---- 667
            ..:| .:..||.:    | :::|...||.::.                  |:...|..|.|
Zfish   458 DIIEDMTESRPNY----W-FMLCWKYLTPLVSLMSFVYSMVRYTPLTFNRWYVYPDWAYALGWLL 517

  Fly   668 -LAEYL--PRWA 676
             |:..|  |.||
Zfish   518 ALSSILLVPGWA 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	118/506 (23%)
si:ch211-132b12.6	NP_001038523.1	SLC6sbd-TauT-like	11..550	CDD:271387	126/532 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910