DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment blot and slc6a22.2

DIOPT Version :9

Sequence 1:	NP_524125.2	Gene:	blot / 39939	FlyBaseID:	FBgn0027660	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_005166102.1	Gene:	slc6a22.2 / 561024	ZFINID:	ZDB-GENE-030616-628	Length:	608	Species:	Danio rerio

Alignment Length:	578	Identity:	136/578 - (23%)
Similarity:	230/578 - (39%)	Gaps:	144/578 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 PAVEDESNKQTKCSVFRGLVLCLCLNLSYANVVRFPRELDRY------GSAYLVPYVVLLFLVGL 262
            ||.|..:||........|.::.|      .||.|||     |      |.|:.||||:.||..|:
Zfish    26 PAREQWANKLEFLLAVAGHIIGL------GNVWRFP-----YLCYKNGGGAFFVPYVLFLFTCGI 79

  Fly   263 PMVLLEISVGQFLGQGAAHTWR-ASPIFKGACMISRFASWLSAIWVSLQAVLALAYIGMFAS--N 324
            |:..||.|:|||..||....|| ..|:|:|....|:.....:.::..:  :||.|::.:|:|  :
Zfish    80 PLFFLETSLGQFTSQGGITCWRKICPLFEGLGFGSQVVVLYTGVYYII--ILAWAFLYLFSSFTS 142

  Fly   325 DLPFRECAGPVKLRLSGYLLTGTSGQECLQ-----LTFLTP---------FWRNPLYFGL----- 370
            :||:..|        :.|..|    ..|::     :|..:|         ||...: .||
Zfish   143 ELPWASC--------NNYWNT----PSCMEFSESNITEYSPNKTTSPVIEFWERRI-LGLSGGIE 194

  Fly   371 --------LAAGLIGLWIVVMLCT-HNAKILRRSIF---VFGLVGLVLL----CTLTGWEVRNSF 419
                    ||..|:..||:...|. ...|...:.::   .|..:.|::|    .||.|  ..|..
Zfish   195 QIGNVRWDLALCLLLAWIICYFCVWKGVKSTGKVVYFTATFPYLMLIVLLVRGLTLPG--AINGI 257

  Fly   420 SRHYFPELWGFDSNLLAESNIWFNALMQVLFSVNCGFGALPMITGKFLYKGDAVRTSVVYLCFNL 484
            :.:.:|     |.:.|.:..:|.:|..|:.:|.....|.|..:.....|..:..| ..||||
Zfish   258 TFYLYP-----DPSRLKDPQVWMDAGSQIFYSYGVCTGVLTALGSYNKYDNNCYR-DCVYLC--- 313

  Fly   485 LINAIAVTLFMVQFDL-SSNGFQNMEELKPLTAI-----------YDRVLNGSREGDSHLLQHLV 537
            |:|::  |.|:..|.: |..||...|:...::.:           |.|.:            .|:
Zfish   314 LLNSL--TSFVAGFAIFSVLGFMADEQGVDISLVAESGPGLAFIAYPRAV------------ALM 364

  Fly   538 P-----SLIYALIIL-----------SAMVSITVAVYTSTRLVPRRPNYV---ICLIGLVVAVIS 583
            |     ::.:.::|:           .|:|:....:|.|...|..|..::   ||.....|.::.
Zfish   365 PLPQLWAIFFFIMIIFLGLDSEFVYQEALVTSISDMYPSFFQVGHRRKFLLLFICSASFFVGLLM 429

  Fly   584 FAAPKFLIARVLD-SRLVGTMVVTALVFELIAITWIYGAKNIYTDLEFSIGRPIFRVWMWL---W 644
            .......:.::.| ....|..::|..:.:.|.:.|:|||...|..:|..||   :|.|.::   |
Zfish   430 VTEGGLYVFQLFDYYACSGMTLLTFAILQSICVGWVYGADRHYDCVEDMIG---YRPWPFMKCCW 491

  Fly   645 -VICPAILTGILVWWCADDDQYDLLA---EY-LPRWAPIL---FVLAVIVIIACVQIF 694
             .:.|||.||..::...   ||..|.   || .|.|...:   |.|:..:::....|:
Zfish   492 KYLTPAICTGTFIFSLV---QYTPLKFNNEYEYPWWGYAIGGFFTLSSTLLVPLWMIY 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	121/519 (23%)
slc6a22.2	XP_005166102.1	SLC6sbd-TauT-like	28..565	CDD:271387	134/576 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810