DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment blot and slc6a11a

DIOPT Version :9

Sequence 1:	NP_524125.2	Gene:	blot / 39939	FlyBaseID:	FBgn0027660	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001091857.1	Gene:	slc6a11a / 558960	ZFINID:	ZDB-GENE-030131-3729	Length:	590	Species:	Danio rerio

Alignment Length:	579	Identity:	138/579 - (23%)
Similarity:	236/579 - (40%)	Gaps:	127/579 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 LSYANVVRFPRELDRY------GSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQGAAHTWR-ASP 287
            :...||.|||     |      |.|:.:|||:.|...|:|:.:||.|:||:..||....|| ..|
Zfish    39 IGLGNVWRFP-----YLCYKNGGGAFFIPYVLYLVTCGIPLFVLETSLGQYTSQGGIMCWRKVCP 98

  Fly   288 IFKGACMISRFASWLSAIWVSLQ--AVLALAYIGMFAS--NDLPFRECAGP----VKLRLSGYLL 344
            :|:|    ..:||.|..::.|:.  .::|.|::.:|:|  .:||:..|..|    ..:.|||...
Zfish    99 LFEG----MGYASQLIIVYGSITYIIIIAWAFLYLFSSFNVELPWASCNNPWNTDTCIVLSGRNS 159

  Fly   345 TGTSGQECLQLTFLTPFWRNPL--------YFGL----LAAGLIGLWIVVMLCT-HNAKILRRSI 396
            :..........:.:..||.:.:        :.|.    ||..|:.:||:|..|. ...|...:::
Zfish   160 SSELASPLNSSSSVMEFWHHRVLRLSSGVEHLGTVRWDLALILLLVWILVYFCIWKGVKSTGKAV 224

  Fly   397 F---VFGLVGLVLL----CTLTGWEVRNSFSRHYFPELWGFDSNLLAESNIWFNALMQVLFSVNC 454
            :   .|..|.|::|    .||.|  ..|....:.:|:|     ..||:..:|.:|..|:.:|...
Zfish   225 YFTATFPYVMLLILLLRGVTLPG--ALNGIYYYMYPDL-----TRLADPQVWMDAGTQIFYSYAI 282

  Fly   455 GFGALPMITGKFLYKGDAVRTSVVYLCFNLLINAIAVTLFMVQFDLSSNGFQNMEELKPLTAIYD 519
            ..|.|..:.....|..:..|.| .|||   |:|  :.|.|:       .||          ||:.
Zfish   283 CLGYLSSLGSYNQYNNNCYRDS-FYLC---LLN--SGTSFL-------GGF----------AIFS 324

  Fly   520 RVLNGSREG--DSHLLQHLVPSLI---------------------YALIIL-----------SAM 550
            .:.:.::|.  |..|:....|.|:                     :.:|||           |.|
Zfish   325 VLGHMAQEQGVDISLVAESGPGLVFIVYPQAVTMLPLSQFWAVCFFIMIILLGLDSQFVGLESIM 389

  Fly   551 VSITVAVYTSTRLVPRRPNYV--ICLIGLVVAVISFAAPKFLIARVLDSRLV-GTMVVTALVFEL 612
            .|:|....|..|...||...:  |||:...:.::........|.::.|..:. ||.::.....:.
Zfish   390 TSVTDIFPTVLRRGFRREMLLLGICLVCYFMGLLMITEGGLYIIQLFDHYVCSGTTLLFLATCQS 454

  Fly   613 IAITWIYGAKNIYTDLEFSIGRPIFRVW-----MWLWVICPAILTGILVWWCADDDQYDLLAEYL 672
            :||.|:|||...|.:::..||   ::.|     .||:| .|::..|..::............:|:
Zfish   455 VAIGWVYGADRFYENIQDMIG---YKPWPMVKYCWLYV-TPSVCVGTFIFSLVKYSPLKFNNKYM 515

  Fly   673 -PRWA-PILFVLAV----IVIIACVQIFRQVEYNFFGMICEASKPAKEWGPAD-PLARH 724
             |.|| .|.:.|||    ::.|..:....:.:..|:..:..|..||::...:. |.|.|
Zfish   516 YPWWAYGIGWFLAVSSLSLIPINMIYKLHKGKGTFWERLQLACSPAEDLPQSQRPSAHH 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	122/505 (24%)
slc6a11a	NP_001091857.1	SLC6sbd-TauT-like	21..560	CDD:271387	133/563 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900