Protein Alignment blot and slc6a6a

DIOPT Version :10

• Sequence 1: NP_524125.2
• Gene: blot / 39939
• FlyBaseID: FBgn0027660
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_001119858.1
• Gene: slc6a6a / 556480
• ZFINID: ZDB-GENE-081104-1
• Length: 625
• Species: Danio rerio
• Alignment Length: 619
• Identity: 144/619 - (23%)
• Similarity: 239/619 - (38%)
• Gaps: 173/619 - (27%)

  Fly   234 NVVRFPRELDRY------GSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQGAAHTW-RASPIFKG 291
            ||.|||     |      |.|:|:||.:.||..|||:..||:::|||..:|....| :..|||.|
Zfish    63 NVWRFP-----YLCYKNGGGAFLIPYFIFLFGGGLPVFFLEVALGQFTSEGGITCWGKLCPIFTG 122

  Fly   292 ACMISRFASWLSAIWVSLQ-----AVLA--LAYIGMFASNDLPFRECAGPVKLRLSGYLLTGTSG 349
                   ..:.|.|.|||.     .:||  |.|:.....::||:..|.            ...:.
Zfish   123 -------IGYASIIIVSLLNIYYIVILAWGLYYLLQCFQHELPWARCR------------HSWNT 168

  Fly   350 QECLQLTF------------------LTPFW-RNPLYF--------GL---LAAGLIGLWIVVML 384
            :.|::.|.                  :|.|| ||.|..        ||   ||..|:.:|::...
Zfish   169 ENCVEDTVRKNKTLWLSANATNFTSPVTEFWERNVLSISSGIDEVGGLKWELALCLLAVWVICFF 233

  Fly   385 C-----THNAKILR-RSIFVFGLVGLVLL---CTLTGWEVRNSFSRHYFPELWGFDSNLLAESNI 440
            |     ....|::. .:.|.| |:.:|||   .||.|  .......:.:|:|     :.|.:..:
Zfish   234 CIWKGVKSTGKVVYFTATFPF-LMLIVLLIRGVTLPG--ATEGIKFYLYPDL-----SRLKDPEV 290

  Fly   441 WFNALMQVLFSVNCGFGALPMITGKFLYKGDAVRTSVVYLCFN---LLINAIA---VTLFMVQ-- 497
            |.:|..|:.||.....||:..:.....||.:..|..::..|.|   ..::..|   |..||.|
Zfish   291 WIDAGTQIFFSYAICLGAMTSLGSYNKYKYNCYRDCMLLGCLNSGTSFVSGFAIFSVLGFMAQEQ 355

  Fly   498 ----FDLSSNG-------FQNMEELKPLTAIYDRVLNGSREGDSHLLQHLVPSLIYALIIL---- 547
                .|::.:|       :.....:.||..::                    ::::.:::|
Zfish   356 GIAIADVAESGPGLAFIAYPKAVTMMPLPTVW--------------------AILFFIMLLLLGL 400

  Fly   548 -SAMVSITVAVYTSTRLVPR--RPNY-------VICLIGLVVAVISFAAPKFLIARVLDSRLV-G 601
             |..|.:...:.:...|.|.  |..|       |||:|..::.:.........:.::.|.... |
Zfish   401 DSQFVEVEGQITSLVDLYPSLLRKGYRREIFIAVICVISYLLGLTMVTKGGMYVFQLFDYYAASG 465

  Fly   602 TMVVTALVFELIAITWIYGAKNIYTDLEFSIG-RPIFRVWM-WLW-VICPAILTGILVWWCADDD 663
            ..::....||.:|:.|:|||.|.|..:|..|| ||  ..|| |.| :|.|.:..|..|:......
Zfish   466 VCLLWVAFFECVAVAWVYGADNFYDAIEDMIGYRP--NSWMKWSWMLITPVLCVGCFVFSLVKYK 528

  Fly   664 --QYDLLAEYLPRWAPIL---FVLAVIVIIACVQIFRQVEYNFFGMICE------------ASKP 711
              .|:.|.:| |.|:..|   ..||.::.|..:.:.:.::.:  |.:.|            ||..
Zfish   529 PLTYNKLYKY-PDWSIGLGWALALASMICIPMMVVIKIIQSD--GSLIERIKAVAAPVKGGASSR 590

  Fly   712 AKEWG--------PADPLARHSW-KQWRSVCQDT 736
            .||:.        |.||...|:: |...::.:.|
Zfish   591 PKEYSLKNSELLHPLDPNGIHAFSKHTHTIVETT 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	123/514 (24%)
slc6a6a	NP_001119858.1	SLC6sbd_TauT	41..582	CDD:271398	134/575 (23%)