DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment blot and slc6a16a

DIOPT Version :9

Sequence 1:	NP_524125.2	Gene:	blot / 39939	FlyBaseID:	FBgn0027660	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_021327051.1	Gene:	slc6a16a / 555229	ZFINID:	ZDB-GENE-061009-43	Length:	693	Species:	Danio rerio

Alignment Length:	596	Identity:	129/596 - (21%)
Similarity:	237/596 - (39%)	Gaps:	174/596 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 NLSYANVVRFPRELDRY------GSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQGAAHTWR-AS 286
            ::...||.|||     |      |.|:::.||:||.::|:|:..:|::.||.:.||:...|: .|
Zfish    59 SVGLGNVWRFP-----YLCHQNGGGAFMLLYVMLLLIIGVPLFFMELAAGQSIRQGSIGVWKHIS 118

  Fly   287 PIFKG----ACMISRFASWLSAIWVSLQAVLALAYIGMFASNDLPFRECAGPVKLRLSGYLLTGT 347
            |...|    :||:..|.    |::.::....:|.|:|......||:.:|  ||.      :::..
Zfish   119 PRLAGIGYSSCMVCFFV----ALYYNVIIAWSLFYMGNSFQYPLPWEQC--PVD------MISNQ 171

  Fly   348 SGQECLQLTFLTPFW----------------RNPLYFGLLAAGLIGLWIVVMLC-----THNAKI 391
            :.:||...:..:.||                .||:..|.|.|.    |.:|.|.     ..:||:
Zfish   172 TVKECAASSPTSYFWFRKALDISDSIDQSGEFNPIMTGCLLAA----WAIVCLAMIKGIKSSAKV 232

  Fly   392 LR-RSIFVFGLVGLVLLCTLTGWEVR--------NSFSRHYFP--ELWGFDSNLLAESNIWFNAL 445
            :. .|:|.:.    ||:|.|    :|        :.....::|  |:||       |..:|..|.
Zfish   233 MYFSSVFPYA----VLICFL----IRGLMLDGAIDGIKYMFYPKVEIWG-------EVQVWRQAA 282

  Fly   446 MQVLFSVNCGFGAL-------P----------MITG-KFLYKGDAVRTSVVYLCF---NLLINAI 489
            .||.|::..|:|::       |          |::| .|:....|.....|.|.|   |:.::.:
Zfish   283 TQVFFALGLGYGSVIAYSSYNPIHNNCHRDAIMVSGINFMTSVLASLVVFVVLGFRAKNIALDCV 347

  Fly   490 AVTLF----MVQ----------FDLSSNGFQNMEELKPLTAIYDRVLNGSREGDSHLLQH----- 535
            |..:.    |.|          |::|......:::.:...:.|..:| ||...|..|.:.
Zfish   348 ATNVARMAEMAQTGSSQHWRPLFNMSDPKSVVLQDYRQWYSSYGSLL-GSNITDCDLEREMSKGV 411

  Fly   536 ---------------LVP-----SLIYALIILS--------AMVSITVAVYTSTRLVPRRPNYVI 572
                           |.|     |.::.|::|:        .|..|...:..:.|::.|....:.
Zfish   412 EGTGLAFIAFTEAMALFPASPFWSTLFFLMLLNLGLSTMFGTMQGILTPLMDNFRVLGRHKTMLT 476

  Fly   573 ---CLIGLVVAVISFAAPKFLIARVLDSRLVGTMVVTALVFELIAITWIYGAKNIYTDLEFSI-G 633
               |::|.::.::...........:.|.......::..::||.:::.|||||.....|:|..: .
Zfish   477 VCSCILGFLIGLLFTQRSGNYFVTMFDDYSATLPLIIVVIFETVSVAWIYGADRFLDDVEVMLHW 541

  Fly   634 RPIFRVWMWLW-VICPAILTGIL---------------VWWCADDDQYDLLAEYLPRWAPILFVL 682
            ||.. |:.:|| .:|...:.|:|               .|......:..|  || |.||  |.||
Zfish   542 RPPV-VYRYLWKYVCLLGMVGLLAASLLRMVFKRPTYTAWNHTTGSEASL--EY-PGWA--LVVL 600

  Fly   683 AVIVIIACVQI 693
            ::::|:|.:.:
Zfish   601 SMLIIVASLPV 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	118/560 (21%)
slc6a16a	XP_021327051.1	SLC6sbd-B0AT-like	42..617	CDD:271364	129/596 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000