DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment blot and SLC6A17

DIOPT Version :9

Sequence 1:	NP_524125.2	Gene:	blot / 39939	FlyBaseID:	FBgn0027660	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001010898.1	Gene:	SLC6A17 / 388662	HGNCID:	31399	Length:	727	Species:	Homo sapiens

Alignment Length:	833	Identity:	161/833 - (19%)
Similarity:	290/833 - (34%)	Gaps:	262/833 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 SEIQGGYHDMDHD--------AVSKNFSISASAHNITTASNAKLLPAVEDESNKQTK---CSVFR 220
            |::....|..:|.        |:.:......|..|:...:..| ..|||:|.:.:.:   .|..:
Human     5 SKVTQREHSSEHVTESVADLLALEEPVDYKQSVLNVAGEAGGK-QKAVEEELDAEDRPAWNSKLQ 68

  Fly   221 GLVLCLCLNLSYANVVRFPRELDRY-GSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQGAAHTW- 283
            .::..:..::...|:.|||....:. |.||||||:|||.::|:|:..||::|||.:.:|:...|
Human    69 YILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWH 133

  Fly   284 ----RASPIFKGACMISRFASWLSAIWVSLQAVLALAYIGMFAS--NDLPFRECAGPVKLRLSGY 342
                |...|...:|::..|      :.:....::..:....|.|  ..||:.||  ||....|..
Human   134 YICPRLGGIGFSSCIVCLF------VGLYYNVIIGWSIFYFFKSFQYPLPWSEC--PVVRNGSVA 190

  Fly   343 LLTGTSGQECLQLTFLTPFW-RNPLYFG-----------------LLAAGLIGLWIVVMLCTHNA 389
            ::..    ||.:.:..|.|| |..|...                 |:|..::|:.:|..:.:...
Human   191 VVEA----ECEKSSATTYFWYREALDISDSISESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGK 251

  Fly   390 KILRRSIFVFGLVGLVLLCTLTGWEVRNSFSR-------HYF-PELWGFDSNLLAESNIWFNALM 446
            .:...|:|.:    :||.|.|    ||....|       |.| |:|     :.:.:..:|..|..
Human   252 VMYFSSLFPY----VVLACFL----VRGLLLRGAVDGILHMFTPKL-----DKMLDPQVWREAAT 303

  Fly   447 QVLFSVNCGFGALPMITGKFLYKG-------DAVRTSVVYLCFNLLINAIAVTLFMVQFDLSSN- 503
            ||.|::..|||.:...:.   |..       ||...|.:    |...:.:|..:........:|
Human   304 QVFFALGLGFGGVIAFSS---YNKQDNNCHFDAALVSFI----NFFTSVLATLVVFAVLGFKANI 361

  Fly   504 --------------GFQNMEEL----------------KPLTAIYDRVLNGSREGDSHL------ 532
                          |:.|...|                |....:|:.::....:..|.|
Human   362 MNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQFSALGLDPCL 426

  Fly   533 ----------------------LQHLVPSLIYALIILSAMVSITVAVYTSTRLVPRRPNYVICLI 575
                                  :.|...|..::::....::::.:.....|            :.
Human   427 LEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGT------------MA 479

  Fly   576 GLVVAVI-SFAAPK--FLIARVLDSRLVG--------------------TMVVTALV-FELIAIT 616
            |:...:| :|..||  |.:...:.:.|||                    |:.:|.:| .|.||:.
Human   480 GITTPIIDTFKVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILENIAVA 544

  Fly   617 WIYGAKNIYTDLEFSIG-RPI-FRVWMWLWV--ICPAILT------------GILVWWCADDDQY 665
            ||||.|....:|...:| ||. |..:||.:|  :|.|:||            |...|...:..:.
Human   545 WIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSAWIKEEAAER 609

  Fly   666 DLLAEYLPRWAPILFVLAVIVIIACVQIFRQVEYNFFGMICEASKPAKEWGPADPLARHSWKQWR 730
            .|   |.|.||  :.:|..::::|.:.|                       |...:.||
Human   610 YL---YFPNWA--MALLITLIVVATLPI-----------------------PVVFVLRH------ 640

  Fly   731 SVCQDTGRRDFTLRRRGTRDYTHSIKKGQYSSATKYGVQNGGQTQTPMHQQHWKSSTPGNSSPNY 795
                      |.|...|:...:.|.|||:...... .::...:|:..:.:...::.:|..:..:|
Human   641 ----------FHLLSDGSNTLSVSYKKGRMMKDIS-NLEENDETRFILSKVPSEAPSPMPTHRSY 694

  Fly   796 SGSMFGDSAIEEDISVDKFPGITQQQYVPFQASDTKQSRYSQRIRQTAQPQTQ 848
            .|                 ||.|.    |.:.|.....||.......:.|:::
Human   695 LG-----------------PGSTS----PLETSGNPNGRYGSGYLLASTPESE 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	119/579 (21%)
SLC6A17	NP_001010898.1	SLC6sbd_NTT4	60..648	CDD:271403	133/675 (20%)
SLC6A17	NP_001010898.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	680..727		11/68 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910