Protein Alignment blot and SLC6A18

DIOPT Version :9

• Sequence 1: NP_524125.2
• Gene: blot / 39939
• FlyBaseID: FBgn0027660
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_872438.2
• Gene: SLC6A18 / 348932
• HGNCID: 26441
• Length: 628
• Species: Homo sapiens
• Alignment Length: 642
• Identity: 133/642 - (20%)
• Similarity: 237/642 - (36%)
• Gaps: 165/642 - (25%)

  Fly   222 LVLCLCLNLSYANVVRFPRELDRY-GSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQGAAHTWRA 285
            |:.|....:...|:.|||.....| |.|:|:|||:.|...|:|:..:|:::||.|.:|:...|.|
Human    28 LLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVELAIGQRLRKGSVGVWTA 92

  Fly   286 -SPIFKGACMISRFASWLSAIWVSLQAVLALAYIGMFASNDLPFRECAGPVKLRLSGYLLTGTSG 349
             ||...|..:.....|:|.:::.:......|.|:.....:.||:..|  |..|..:|::
Human    93 ISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPWSSC--PPDLNRTGFV------ 149

  Fly   350 QECLQLTFLTPFW-RNPLYF--GLLAAGLIGLWIVVMLCTHNAKILRRSIFVFGLVGLVLLCTLT 411
            :||...:.::.|| |..|..  .:..:|.|..|:::.|....|              :|.:|.:.
Human   150 EECQGSSAVSYFWYRQTLNITADINDSGSIQWWLLICLAASWA--------------VVYMCVIR 200

  Fly   412 GWEVRNSFSRHYFPELWGF--------------------------DSNLLAESNIWFNALMQVLF 450
            |.|......  ||..|:.:                          :.::|....:|.:|..|:.|
Human   201 GIETTGKVI--YFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNMHILQNPRVWLDAATQIFF 263

  Fly   451 SVNCGFGALPMITGKFLYKGDAVRTSVVYLCFNLLINAIA-VTLFMVQFDLSSNGFQNMEELKPL 514
            |::..||...........:.|..:.:||....|.:.:..| :.:|.|....::|.:::..:...|
Human   264 SLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASIAVFSVLGFKATNDYEHCLDRNIL 328

  Fly   515 TAIYD---RVLNGSREGDSHLLQHL---VPSLIYALIILSAMV-----------SITVAVYTSTR 562
            :.|.|   ...:.||:....:|.||   .|..:..|.:.:.::           .:...|:|.|.
Human   329 SLINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQLPLKACLLEDFLDKSASGPGLAFVVFTETD 393

  Fly   563 L-VPRRPNYVICLIGLVVAV---ISFAAPKFLIARVLD----SRLVGTMVVTALV---------- 609
            | :|..|.:.:...|::..:   ..|...:.:|..:||    .|.|....:|.||
Human   394 LHMPGAPVWAMLFFGMLFTLGLSTMFGTVEAVITPLLDVGVLPRWVPKEALTGLVCLVCFLSATC 458

  Fly   610 ---------------------------FELIAITWIYGAKNIYTDLEFSIGRPIFRVWMWLW-VI 646
                                       .|::.:.::||.|....|:.:..||.....|...| |:
Human   459 FTLQSGNYWLEIFDNFAASPNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVV 523

  Fly   647 CPAILT-----GILVWW-----CADDDQYDLL----AEYLPRWAPILFVLAVIVIIACVQIFRQV 697
            .|.:||     .||::|     .|.:.:|:|.    .:..|.||     .|..|:::.:.:.
Human   524 SPLLLTIFVAYIILLFWKPLRYKAWNPKYELFPSRQEKLYPGWA-----RAACVLLSLLPVL--- 580

  Fly   698 EYNFFGMICEASKPAKEWGPADPLA------RHSWKQWRSVCQDTGRRDFTLRRRGT 748
                             |.|...||      |.:|:. |....||..|..|..|..|
Human   581 -----------------WVPVAALAQLLTRRRRTWRD-RDARPDTDMRPDTDTRPDT 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	112/541 (21%)
SLC6A18	NP_872438.2	SLC6sbd_B0AT3	17..591	CDD:212086	124/611 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	602..628		6/18 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910