DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment blot and ine

DIOPT Version :9

Sequence 1:	NP_524125.2	Gene:	blot / 39939	FlyBaseID:	FBgn0027660	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001162871.1	Gene:	ine / 33659	FlyBaseID:	FBgn0011603	Length:	943	Species:	Drosophila melanogaster

Alignment Length:	828	Identity:	171/828 - (20%)
Similarity:	295/828 - (35%)	Gaps:	251/828 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SDEALAEQFSLARAGSGTKP----PATP-TYRQIS-----GAMATLPRHDNNHNHNDNSSRIRSD 64
            |..:.|.:|.:..|..||.|    .|.| .:||.|     .|||......:...|....:|..|:
  Fly    56 SSSSRAHKFIIIPATPGTPPGSGAVAGPLPFRQTSSTTSLAAMAAALHKQSPLRHTSVRTRPSSE 120

  Fly    65 STATSRTCVYIGGAPTGGGNGNEQISVTLDRRQPQRMSWLNMRRAKANE--------------TD 115
            .....:.   :...||...: ...::.|:|               ..||              ..
  Fly   121 VLQPGQV---LANQPTAAVS-TSTVTFTID---------------DCNEEGDAIPAAASVPAPVT 166

  Fly   116 LPTVTPSPQTTRSCISTVSSVVDS---------------------------------------GG 141
            :|.::|:| .|.:|.:|.:...||                                       .|
  Fly   167 MPAISPTP-ATLTCTTTTTMAGDSVAVSPLSMELKSRLGSHHSSMRSVVSGYLPGLSDSSGNLVG 230

  Fly   142 GRTTATSGRISSSGI-----VTLSDSNNTLSEIQGGYHDMDHDAVSKNFSISASA--------HN 193
            |.:.||||..:.:.:     .:||.|:....|:.|.....|..:|....||...:        ..
  Fly   231 GVSMATSGLQAPNPLYMQPQASLSGSSYHFHELAGNQIYSDVTSVRSLASIGIGSTDGRKLVIRR 295

  Fly   194 ITTASN-----------------------------AKLLPAVEDESNKQTKCSVFRGLVLCLCLN 229
            :.|.:|                             |:|.|..:..:||      .:.::.|:..:
  Fly   296 VPTTANELFDMVNPQTPPPLGVDDDDSYLDMSDETAQLKPRQQHWANK------MQFVLACIGYS 354

  Fly   230 LSYANVVRFPRELDRY------GSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQG-AAHTWRASP 287
            :...||.|||     |      |..:||||.::||:..:|::.:|:||||:.|:| .....:..|
  Fly   355 VGLGNVWRFP-----YMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRGPIGALGQLCP 414

  Fly   288 IFKGACMISRFASWLSAIWVSLQAVLALAYIGMFASNDLPFRECAG---------PVK--LRLSG 341
            :||||.:.|...|:|.:.:.|:....::.|.......::|:.:|..         |.:  :..|.
  Fly   415 LFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPDCWVPQRKGINASA 479

  Fly   342 YLLTGTSGQECLQLTFLTPFWRNPL--------YFGL----LAAGLIGLWIVVMLCT-----HNA 389
            ...:.|..:|         |:.|.:        |.|:    |.|.||..|::|...|     .:|
  Fly   480 PDTSRTPSEE---------FFENKVLQISGGLEYPGMMRWELFACLICAWLMVYFATWKSIKSSA 535

  Fly   390 KILRRSI---FVFGLVGLVLLCTLTGWEVRNSFSRHYFPELWGFDSNLLAESNIWFNALMQVLFS 451
            |:...:.   ||..::.:|...||.|   .....|.:|...|    :.|..:|:|.||..|...|
  Fly   536 KVRYFTATFPFVLIIILMVRAVTLDG---AAEGLRFFFRPKW----SELKNANVWINAASQNFNS 593

  Fly   452 VNCGFGALPMITGKFLYKGDAVRTSVVYLCFNLLINAIAVTLFMVQFDLSSNGFQNMEELKPLTA 516
            :...||::........|..:.:|.:|.....|::     .:|.:..|..|:.|...:|:   .|.
  Fly   594 LGITFGSMISFASYNKYNNNILRDTVAVSAVNMI-----TSLLVGIFAFSTLGNLALEQ---NTN 650

  Fly   517 IYDRVLNGSREGDSHLLQHLVPSLIYAL------------------------IILSAMVSITVAV 557
            :.|.:.:|             |.:|:.:                        :.|::..:|...|
  Fly   651 VRDVIGDG-------------PGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVV 702

  Fly   558 YTS-----TRLVPRRPNYVICLIGLVVAVIS--FAAPKFLIARV----LDSRLVGTMVVTALVF- 610
            .||     .|.:.|...|...:: |.|.|||  |..|..:...:    |......::.:..|.|
  Fly   703 VTSIQDGFPRWIKRHLGYHEIVV-LFVCVISCLFGMPNIIQGGIYYFQLMDHYAASVTIMFLAFC 766

  Fly   611 ELIAITWIYGAKNIYTDLEFSIGR-PIFRV-WMWLWVICPAILTGILV 656
            ::|||.|.||...:..:::...|: |.|.: ..|| |:.|.:|..|.|
  Fly   767 QMIAIAWFYGTGRLSKNVKQMTGKAPSFYLRSCWL-VLGPCLLFAIWV 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	117/514 (23%)
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	119/527 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910