Protein Alignment blot and Slc6a3

DIOPT Version :9

• Sequence 1: NP_524125.2
• Gene: blot / 39939
• FlyBaseID: FBgn0027660
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_036826.1
• Gene: Slc6a3 / 24898
• RGDID: 3715
• Length: 619
• Species: Rattus norvegicus
• Alignment Length: 648
• Identity: 135/648 - (20%)
• Similarity: 230/648 - (35%)
• Gaps: 176/648 - (27%)

  Fly   195 TTASNAKLLPAVEDESNKQTKCSVFRGLVLCLCLNLSYANVVRFPRELDRY------GSAYLVPY 253
            :|..|....|....|....:|...|...|:...::|  |||.|||     |      |.|:||||
  Rat    45 STLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDL--ANVWRFP-----YLCYKNGGGAFLVPY 102

  Fly   254 VVLLFLVGLPMVLLEISVGQFLGQGAAHTWRASPIFKGACMISRFASWLSAIWVSLQAVLALAYI 318
            ::.:.:.|:|:..:|:::|||..:|||..|:..|:.||........|:....:.::....||.|.
  Rat   103 LLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYF 167

  Fly   319 GMFASNDLPFREC---------------------------------------------------A 332
            ....:.|||:..|                                                   .
  Rat   168 FSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDL 232

  Fly   333 GPVKLRLSGYLLTGTSGQECLQLTFLTPFWRNPLYF----GLLAAGLIGLWIVVML--CTHNAKI 391
            ||.:.:|:.          ||.|..:.      |||    |:..:|.: :||...:  ....|.:
  Rat   233 GPPRWQLTA----------CLVLVIVL------LYFSLWKGVKTSGKV-VWITATMPYVVLTALL 280

  Fly   392 LRRSIFVFGLVGLVLLCTLTGWEVRNSFSRHYFPELWGFDSNLLAESNIWFNALMQVLFSVNCGF 456
            ||         |:.|...:.|  :|...|..::         .|.|:::|.:|..||.||:..||
  Rat   281 LR---------GVTLPGAMDG--IRAYLSVDFY---------RLCEASVWIDAATQVCFSLGVGF 325

  Fly   457 GALPMITGKFLYKGDAVRTSVVYLCFNLLINAIAVTLFMVQFDL-SSNGFQNMEELKPLTAIYDR 520
            |.|...:....:..:..|.:::....|      ::|.|...|.: |..|:...:...|:..:
  Rat   326 GVLIAFSSYNKFTNNCYRDAIITTSIN------SLTSFSSGFVVFSFLGYMAQKHNVPIRDV--- 381

  Fly   521 VLNGSREGDSHLLQHLVPSLIYALIILSA--------------------MVSITVAVYTSTRLVP 565
                :.:|.. |:..:.|..|..|.:.||                    |.|:...:....:|:.
  Rat   382 ----ATDGPG-LIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLH 441

  Fly   566 RRPNYVICLIGLVVAVISFAAPKFLIAR-------VLDSRLVGTMVVTALVFELIAITWIYGAKN 623
            |...  :..:|:|:|  :|....|.:..       :||....||.::..::.|.|.:.|.||.:.
  Rat   442 RHRE--LFTLGIVLA--TFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQ 502

  Fly   624 IYTDLEFSIGRPIFRVWMWLW-VICPAILTGILVWWCADDDQYDLLAEYLPRWAPILFVLAVIVI 687
            ...|::...|:.....|...| ::.|..|..::|............|...|.||..|..:.....
  Rat   503 FSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSS 567

  Fly   688 IACVQIFRQVEY-----NFFGMICEASKPAKEWGPADPLARHSWKQWRSVCQDTGR-RDFTLR 744
            :|.|.|:...::     :|...:..|..|.|:         |.       ..|.|. |.||||
  Rat   568 MAMVPIYATYKFCSLPGSFREKLAYAITPEKD---------HQ-------LVDRGEVRQFTLR 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	110/531 (21%)
Slc6a3	NP_036826.1	SLC6sbd_DAT1	60..613	CDD:212083	128/630 (20%)
		Interaction with TGFB1I1. /evidence=ECO:0000250	560..589		4/28 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900