DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment blot and Slc6a11

DIOPT Version :9

Sequence 1:	NP_524125.2	Gene:	blot / 39939	FlyBaseID:	FBgn0027660	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_766478.1	Gene:	Slc6a11 / 243616	MGIID:	95630	Length:	627	Species:	Mus musculus

Alignment Length:	542	Identity:	126/542 - (23%)
Similarity:	219/542 - (40%)	Gaps:	118/542 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 LSYANVVRFPRELDRY------GSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQGAAHTW-RASP 287
            :...||.|||     |      |.|:|:||||.....|:|:..||.::|||..:|....| |..|
Mouse    63 IGLGNVWRFP-----YLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRRVCP 122

  Fly   288 IFKGACMISRFASWLSAIWVSLQAVLALAYIGMFASN----DLPF---------RECAGPVKLRL 339
            :|:|.    .:|:.:....:::..::.||:...:.||    :||:         .:|....||..
Mouse   123 LFEGI----GYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTEKCVEFQKLNF 183

  Fly   340 SGY----LLTGTSGQECLQLTFLTPFWRNPL--------YFG----LLAAGLIGLWIVVMLCT-H 387
            |.|    |...||.        :..||...:        :.|    .||..|:..|.:...|. .
Mouse   184 SNYSHVSLQNATSP--------VMEFWERRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWK 240

  Fly   388 NAKILRRSIFV---FGLVGLVLL----CTLTGWEVRNSFSRHYFPELWGFDSNLLAESNIWFNAL 445
            ..|...:.::|   |..:.|::|    .||.|  .......:.:|:|     :.|::..:|.:|.
Mouse   241 GTKSTGKVVYVTATFPYIMLLILLIRGVTLPG--ASEGIKFYLYPDL-----SRLSDPQVWVDAG 298

  Fly   446 MQVLFSVNCGFGALPMITGKFLYKGDAVRTSVVYLCFNLLINAIAVTLFMVQFDL-SSNGFQNME 509
            .|:.||.....|.|..:.....|..:..|..::..|.|      :.|.|:..|.: |..||...|
Mouse   299 TQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLN------SGTSFVAGFAIFSVLGFMAYE 357

  Fly   510 ELKPLTAIYDRVLNGSREGDSHL----------LQHLVPSLIYALIIL----SAMVSITVAVYTS 560
            :..|:..:.:     |..|.:.:          |..|..:|.:.::|.    |..|.:...|...
Mouse   358 QGVPIAEVAE-----SGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAV 417

  Fly   561 TRLVPR--RPNYVICLIGLVVAVISFAAPKFL-----------IARVLDSRLV-GTMVVTALVFE 611
            ..:.|:  |..|...|:.|.:::||:    ||           |.::.||... |..::...:||
Mouse   418 VDMYPKVFRRGYRRELLILALSIISY----FLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFE 478

  Fly   612 LIAITWIYGAKNIYTDLEFSIG-RPIFRVWMWLW-VICPAILTGILVWWCADDD--QYDLLAEYL 672
            .:.|.|:||:...|.::|..|| ||:..: .|.| |:.|.|..||.:::.....  :|:.:..|
Mouse   479 CVCIGWVYGSNRFYDNIEDMIGYRPLSLI-KWCWKVVTPGICAGIFIFFLVKYKPLKYNNVYTY- 541

  Fly   673 PRWAPILFVLAVIVIIACVQIF 694
            |.|...:..|..:..:.|:.::
Mouse   542 PAWGYGIGWLMALSSMLCIPLW 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	120/503 (24%)
Slc6a11	NP_766478.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
Slc6a11	NP_766478.1	SLC6sbd_GAT3	44..585	CDD:212077	126/542 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810