Protein Alignment blot and Slc6a1

DIOPT Version :9

• Sequence 1: NP_524125.2
• Gene: blot / 39939
• FlyBaseID: FBgn0027660
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_848818.1
• Gene: Slc6a1 / 232333
• MGIID: 95627
• Length: 599
• Species: Mus musculus
• Alignment Length: 576
• Identity: 128/576 - (22%)
• Similarity: 232/576 - (40%)
• Gaps: 114/576 - (19%)

  Fly   187 ISASAHNITTASN------AKLLPAVEDESNKQTKCSVFRGLVLCLCLNLSYANVVRFPRELDRY 245
            ||........||:      .|:.....|..::.|....|..|:.|:...:...||.|||....:.
Mouse    13 ISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKN 77

  Fly   246 -GSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQGAAHTWRASPIFKGACMISRFAS-WLSAIWVS 308
             |.|:|:||.:.|...|:|:.|||.|:||:...|....|:.:|:|||..:.:...| ||:..::.
Mouse    78 GGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIV 142

  Fly   309 LQAVLALAYIGMFASNDLPFRECAGP--VKLRLSGYLLTGTSGQECLQLTFLTPFWRNPLY---F 368
            :.: .|:.|:....:..||:::|..|  .....|.|.|..|:.    ..:.:..||...::   .
Mouse   143 IIS-WAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLVNTTN----MTSAVVEFWERNMHQMTD 202

  Fly   369 GL---------LAAGLIGLWIVVMLCT-----HNAKILRRSIFVFGLVGLVLL----CTLTGWEV 415
            ||         ||..|...|::|..|.     ...|::..|. .:..:.|::|    .||.|  .
Mouse   203 GLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVVYFSA-TYPYIMLIILFFRGVTLPG--A 264

  Fly   416 RNSFSRHYFPELWGFDSNLLAESNIWFNALMQVLFSVNCGFGALPMITGKFLYKGDAVRTSVVYL 480
            :.....:..|..     ..|::|.:|.:|..|:.||...|.|:|..:.....:..:..|.|::..
Mouse   265 KEGILFYITPNF-----RKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVC 324

  Fly   481 CFNLLINAIA--VTLFMVQF----------DLSSNG----FQNMEE------LKPLTAIYDRVLN 523
            |.|...:..|  |...:|.|          |::::|    |....|      :.||.||
Mouse   325 CINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAI------ 383

  Fly   524 GSREGDSHLLQHLVPSLIYALIILSAMVS--------ITVAVYTSTRLV-PRRPNYV--ICLIGL 577
                            |.::::::..:.|        ||..|....||: .||..::  :|::..
Mouse   384 ----------------LFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIVSY 432

  Fly   578 VVAVISFAAPKFLIARVLDSRLVGTMVVTALV-FELIAITWIYGAKNIYTDLEFSIG-RPIFRVW 640
            ::.:.:.......:.::.|......|.:..|| ||.::|:|.||....|.:::..:| ||.  :|
Mouse   433 LIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPC--IW 495

  Fly   641 MWLWVIC-----PAILTGILVWWCADDDQYDLLAEYLPRWAP---ILFVLAVIVII 688
               |.:|     |.|:.|:.::.........:.:...|:|..   .|..|:.:|:|
Mouse   496 ---WKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLMALSSMVLI 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	115/504 (23%)
Slc6a1	NP_848818.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		2/9 (22%)
		SLC6sbd_GAT1	2..599	CDD:212075	128/576 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599
		PDZ-binding	597..599

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810