DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment blot and Slc6a17

DIOPT Version :9

Sequence 1:	NP_524125.2	Gene:	blot / 39939	FlyBaseID:	FBgn0027660	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001280618.1	Gene:	Slc6a17 / 229706	MGIID:	2442535	Length:	727	Species:	Mus musculus

Alignment Length:	833	Identity:	159/833 - (19%)
Similarity:	286/833 - (34%)	Gaps:	262/833 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 SEIQGGYHDMDHD--------AVSKNFSISASAHNITTASNAKLLPAVE--DESNKQTKCSVFRG 221
            |::....|..:|.        |:.:......|..|:...:..|...|.|  |..::....|..:.
Mouse     5 SKVTQREHSNEHVTESVADLLALEEPVDYKQSVLNVAGETGGKQKVAEEELDTEDRPAWNSKLQY 69

  Fly   222 LVLCLCLNLSYANVVRFPRELDRY-GSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQGAAHTWR- 284
            ::..:..::...|:.|||....:. |.||||||:|||.::|:|:..||::|||.:.:|:...|.
Mouse    70 ILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWHY 134

  Fly   285 ASPIFKGACMISRFASWLSAIWVSL--QAVLALAYIGMFAS--NDLPFRECAGPVKLRLSGYLLT 345
            ..|...|.    .|:|.:..::|.|  ..::..:....|.|  ..||:.||  ||       :..
Mouse   135 VCPRLGGI----GFSSCIVCLFVGLYYNVIIGWSVFYFFKSFQYPLPWSEC--PV-------IRN 186

  Fly   346 GTSG---QECLQLTFLTPFW-RNPLYFG-----------------LLAAGLIGLWIVVMLCTHNA 389
            ||..   .||.:.:..|.|| |..|...                 |:|..::|:.:|..:.:...
Mouse   187 GTVAVVEPECEKSSATTYFWYREALDISNSISESGGLNWKMTLCLLVAWSIVGMAVVKGIQSSGK 251

  Fly   390 KILRRSIFVFGLVGLVLLCTLTGWEVRNSFSR-------HYF-PELWGFDSNLLAESNIWFNALM 446
            .:...|:|.:    :||.|.|    ||....|       |.| |:|     :.:.:..:|..|..
Mouse   252 VMYFSSLFPY----VVLACFL----VRGLLLRGAVDGILHMFTPKL-----DKMLDPQVWREAAT 303

  Fly   447 QVLFSVNCGFGALPMITGKFLYKG-------DAVRTSVVYLCFNLLINAIAVTLFMVQFDLSSN- 503
            ||.|::..|||.:...:.   |..       ||...|.:    |...:.:|..:........:|
Mouse   304 QVFFALGLGFGGVIAFSS---YNKQDNNCHFDAALVSFI----NFFTSVLATLVVFAVLGFKANI 361

  Fly   504 --------------GFQNMEEL----------------KPLTAIYDRV----------------- 521
                          |:.|...|                |..:.:|..:
Mouse   362 MNEKCVVENAEKILGYLNSNVLSRDLIPPHVNFSHLTTKDYSEMYSVIMTVKEKQFPALGLDPCL 426

  Fly   522 ----LNGSREGD-------SHLLQHLVPSLIYALIILSAMVSITVAVYTSTRLVPRRPNYVICLI 575
                |:.|.:|.       :..:.|...|..::::....::::.:.....|            :.
Mouse   427 LEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGT------------MA 479

  Fly   576 GLVVAVI-SFAAPK--FLIARVLDSRLVG--------------------TMVVTALV-FELIAIT 616
            |:...:| :|..||  |.:...:.:..||                    |:.:|.:| .|.||:.
Mouse   480 GITTPIIDTFKVPKEMFTVGCCVFAFFVGLLFVQRSGNYFVTMFDDYSATLPLTVIVILENIAVA 544

  Fly   617 WIYGAKNIYTDLEFSIGRPIFRVWMWLW----VICPAILT------------GILVWWCADDDQY 665
            ||||.|....:|...:|...:|.:.::|    .:|.|:||            |...|...:..:.
Mouse   545 WIYGTKKFMQELTEMLGFQPYRFYFYMWKFVSPLCMAVLTTASIIQLGVSPPGYSAWIKEEAAER 609

  Fly   666 DLLAEYLPRWAPILFVLAVIVIIACVQIFRQVEYNFFGMICEASKPAKEWGPADPLARHSWKQWR 730
            .|   |.|.||  :.:|..::.:|.:.|                       |...:.||
Mouse   610 YL---YFPNWA--MALLITLIAVATLPI-----------------------PVVFILRH------ 640

  Fly   731 SVCQDTGRRDFTLRRRGTRDYTHSIKKGQYSSATKYGVQNGGQTQTPMHQQHWKSSTPGNSSPNY 795
                      |.|...|:...:.|.|||:...... .::...:|:..:.:...::.:|..:..:|
Mouse   641 ----------FHLLSDGSNTLSVSYKKGRMMKDIS-NLEENDETRFILSKVPSEAPSPMPTHRSY 694

  Fly   796 SGSMFGDSAIEEDISVDKFPGITQQQYVPFQASDTKQSRYSQRIRQTAQPQTQ 848
            .|                 ||.|.    |...|:....||.......:.|:::
Mouse   695 LG-----------------PGSTS----PLDNSNNPNGRYGSGYLLASTPESE 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	118/580 (20%)
Slc6a17	NP_001280618.1	SLC6sbd_NTT4	60..648	CDD:271403	132/676 (20%)
Slc6a17	NP_001280618.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	680..727		11/68 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.000