DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment blot and Slc6a6

DIOPT Version :9

Sequence 1:	NP_524125.2	Gene:	blot / 39939	FlyBaseID:	FBgn0027660	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_030111163.1	Gene:	Slc6a6 / 21366	MGIID:	98488	Length:	631	Species:	Mus musculus

Alignment Length:	561	Identity:	134/561 - (23%)
Similarity:	213/561 - (37%)	Gaps:	161/561 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 NVVRFPRELDRY------GSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQGAAHTW-RASPIFKG 291
            ||.|||     |      |.|:|:||.:.||..|||:..||:.:||:..:|....| :..|:|.|
Mouse    73 NVWRFP-----YLCYKNGGGAFLIPYFIFLFGSGLPVFFLEVIIGQYTSEGGITCWEKICPLFSG 132

  Fly   292 ACMISRFASWLSAIWVSLQ-----AVLALAYIGMFAS--NDLPFREC----------AGPVKLRL 339
                   ..:.|.:.|||.     .:||.|...:|.|  .|||:..|          ...::...
Mouse   133 -------IGYASIVIVSLLNVYYIVILAWATYYLFHSFQKDLPWAHCNHSWNTPQCMEDTLRRNE 190

  Fly   340 SGYLLTGTSGQECLQLTFLTP---FW-RNPLYF--GL---------LAAGLIGLWIVVMLC---- 385
            |.::...|:       .|.:|   || ||.|..  |:         ||..|:.:|:|...|
Mouse   191 SHWVSLSTA-------NFTSPVIEFWERNVLSLSSGIDNPGSLKWDLALCLLLVWLVCFFCIWKG 248

  Fly   386 -THNAKILR-RSIFVFGLVGLVLL---CTLTGWEVRNSFSRHYFPELWGFDSNLLAESNIWFNAL 445
             ....|::. .:.|.|.:: ||||   .||.|  .......:.:|     |.:.|.:..:|.:|.
Mouse   249 VRSTGKVVYFTATFPFAML-LVLLVRGLTLPG--AGEGIKFYLYP-----DISRLGDPQVWIDAG 305

  Fly   446 MQVLFSVNCGFGALPMITGKFLYKGDAVRTSVVYLCFN---LLINAIAVTL---FMVQ------F 498
            .|:.||.....||:..:.....||.::.|..::..|.|   ..::..|:..   ||.|      .
Mouse   306 TQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIA 370

  Fly   499 DLSSNG-------FQNMEELKPLTAIYDRVLNGSREGDSHLLQHLVPSLIYALIILSAMVSITVA 556
            |::.:|       :.....:.||...:.                   .|.:.:::|..:.|..|.
Mouse   371 DVAESGPGLAFIAYPKAVTMMPLPTFWS-------------------ILFFIMLLLLGLDSQFVE 416

  Fly   557 VYTS-TRLVPRRPNY------------VICLIGLVVAVISFAAPKFLIARVLDSRLV-GTMVVTA 607
            |... |.||...|::            ::|.|..::.:.........:.::.|.... |..::..
Mouse   417 VEGQITSLVDLYPSFLRKGYRREIFIAILCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWV 481

  Fly   608 LVFELIAITWIYGAKNIYTDLEFSIG-RPIFRVWM-WLW-VICPAILTGILVWWCADDDQYDLLA 669
            ..||...|.||||..|:|..:|..|| ||  ..|| :.| ||.||:..|..|:         .|.
Mouse   482 AFFECFVIAWIYGGDNLYDGIEDMIGYRP--GPWMKYSWAVITPALCVGCFVF---------SLV 535

  Fly   670 EYL----------PRWA----------PILFVLAVIVIIAC 690
            :|:          |.||          .:|.:..||||:.|
Mouse   536 KYVPLTYNKVYRYPDWAIGLGWGLALSSMLCIPLVIVILLC 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	123/508 (24%)
Slc6a6	XP_030111163.1	SLC5-6-like_sbd	51..592	CDD:382020	134/561 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900