DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment blot and Slc6a2

DIOPT Version :9

Sequence 1:	NP_524125.2	Gene:	blot / 39939	FlyBaseID:	FBgn0027660	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_033235.3	Gene:	Slc6a2 / 20538	MGIID:	1270850	Length:	617	Species:	Mus musculus

Alignment Length:	563	Identity:	130/563 - (23%)
Similarity:	218/563 - (38%)	Gaps:	163/563 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 ANVVRFPRELDRY------GSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQGAAHTWRASPIFKG 291
            |||.|||     |      |.|:|:||.:.|.:.|:|:..:|:::||:..:|||..|:..|.|||
Mouse    77 ANVWRFP-----YLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKG 136

  Fly   292 ACMISRFASWLSAIWVSL--QAVLALAYIGMFAS--NDLPFR---------ECAGPVKLRLS--- 340
            .    .:|..|.|::|..  ..::|.:...:|||  .:||:.         .|..|..|..|
Mouse   137 V----GYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHSWNSPNCTDPKLLNASVLG 197

  Fly   341 -------------------GYL-LTGTSGQE-----------CLQLTFLTPFWRNPLYF----GL 370
                               |.| |..:||..           ||.:..:.      |||    |:
Mouse   198 DHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVIVV------LYFSLWKGV 256

  Fly   371 LAAGLIGLWIVVMLCTHNAKILRRSIFVFGLVGLVLLCTLTGWEVRNSFSRHYFPELWGFDSNLL 435
            ..:|.: :||...|          ..||. .|.||...||.|  ..|..:.:..     .|...|
Mouse   257 KTSGKV-VWITATL----------PYFVL-FVLLVHGVTLPG--ASNGINAYLH-----IDFYRL 302

  Fly   436 AESNIWFNALMQVLFSVNCGFGALPMIT--GKF---LYKGDAVRTSVVYLCFNLLINAIAVTLFM 495
            .|:.:|.:|..|:.||:..|||.|....  .||   .|: ||:.||.:. |....|:..|:  |.
Mouse   303 KEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYR-DALLTSTIN-CVTSFISGFAI--FS 363

  Fly   496 VQFDLSSNGFQNMEELKPLTAIYDRVLNGSREGDSHLLQHLVP------------SLIYALIILS 548
            :...::.....|:|::             :.|| :.|:..|.|            ::::.|::|:
Mouse   364 ILGYMAHEHKVNIEDV-------------ATEG-AGLVFILYPEAISTLSGSTFWAVLFFLMLLA 414

  Fly   549 --------AMVSITVAVYTSTRLVPRRPNYVICLIGLVVAVISFAAPKFLIAR-------VLDSR 598
                    .|.::...:....:::.|......|    ||.:.:|....|.|.:       :||:.
Mouse   415 LGLDSSMGGMEAVITGLADDFQVLKRHRKLFTC----VVTISTFLLALFCITKGGIYVLTLLDTF 475

  Fly   599 LVGTMVVTALVFELIAITWIYGAKNIYTDLEFSIGRPIFRVWMWLW-VICPAILTGILVW----- 657
            ..||.::.|::.|.|.::|.||......|::..:|......|...| .:.||.|..::|.
Mouse   476 AAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINF 540

  Fly   658 --WCADDDQYDLLAEYLPRWAPIL---FVLAVIVIIACVQIFR 695
              ...||..|       |.||..:   ..|:.::::....|::
Mouse   541 KPLTYDDYTY-------PPWANWVGWGIALSSMILVPAYVIYK 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	122/522 (23%)
Slc6a2	NP_033235.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
Slc6a2	NP_033235.3	SLC5-6-like_sbd	56..615	CDD:382020	130/563 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810