DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment blot and Slc6a5

DIOPT Version :9

Sequence 1:	NP_524125.2	Gene:	blot / 39939	FlyBaseID:	FBgn0027660	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_976079.1	Gene:	Slc6a5 / 171148	RGDID:	621824	Length:	799	Species:	Rattus norvegicus

Alignment Length:	824	Identity:	175/824 - (21%)
Similarity:	296/824 - (35%)	Gaps:	264/824 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 ETDLPTVTPS-----PQTTRSCISTVSSVVDSGGGRT-------------TATSGRISSSGIVTL 159
            |.|||...|:     |:..||. ||.:....|...|.             ::...:.:|:.:..|
  Rat    36 EQDLPAAAPAAAVQPPRVPRSA-STGAQTFQSADARACEAQRPGVGFCKLSSPQAQATSAALRDL 99

  Fly   160 SDSNNT------------------LSEIQGGYHDMDHDAVSKNFSISASA--HNIT--------- 195
            |:.::.                  :..::|...|       :|.|::...  ||.|
  Rat   100 SEGHSAQANPPSGAAGAGNALHCKIPALRGPEED-------ENVSVAKGTLEHNNTPPVGWVNMS 157

  Fly   196 -------TASNAKLLPA-------VEDESNKQTKCSVFRG-------LVLCLCLNLSYA----NV 235
                   |...|.:||.       .|||...:.|.   ||       .:|.:   :.||    ||
  Rat   158 QSTVVLGTDGIASVLPGSVATTTIPEDEQGDENKA---RGNWSSKLDFILSM---VGYAVGLGNV 216

  Fly   236 VRFP-RELDRYGSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQGAAHTWRASPIFKGACMISRFA 299
            .||| ......|.|:|:||:::|.|.|||:..||:|:|||..||....|:|.|..:|..:.....
  Rat   217 WRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLII 281

  Fly   300 SWLSAIWVSLQAVLALAYIGMFAS--NDLPFRECAGP------------------------VKLR 338
            |.|.||:.::.....|.|  :|||  :.||:..|..|                        ::::
  Rat   282 SVLIAIYYNVIICYTLFY--LFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVIGDHPKIQIK 344

  Fly   339 LSGYLLTG-----------------TSGQECLQLTFLTPF-----------WRNPLYFGLLAAGL 375
            .|.:.:|.                 .||.|.....|:...           |  ||.|.|..|
  Rat   345 NSTFCMTAYPNLTMVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRW--PLPFCLFLA-- 405

  Fly   376 IGLWIVVMLCTHNAKILRRS------IFVFGLVGLVLL----CTLTG-----WEVRNSFSRHYFP 425
               |::|....  ||.::.|      ...|..|.||:|    .||.|     |        ::..
  Rat   406 ---WVIVYASL--AKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIW--------YFIT 457

  Fly   426 ELWGFDSNLLAESNIWFNALMQVLFSVNCGFGALPMITGKFLYKGDAVRTSVVYLCFNLLINAIA 490
            ..|    ..|.::.:|.:|..|:.||::..:|.|..::....:..:..|.:::..|.|...:..|
  Rat   458 PKW----EKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFA 518

  Fly   491 VTLFMVQFDLSSN----GFQNMEELKPLTA--IYDRVLNGSREGDSHLLQHLVPSLIYALIILSA 549
            ..:........:|    ..:|:.:..|..|  :|...|.           .|..|..:|:|....
  Rat   519 GFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALT-----------RLPLSPFWAIIFFLM 572

  Fly   550 MVSITVAVYTSTRLVPRRPNYVICLIGLVVAVISFAAPKFL------------------------ 590
            ::::.:....:|             |..:|..||...||:|
  Rat   573 LLTLGLDTMFAT-------------IETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMIT 624

  Fly   591 -----IARVLDSRLVGTMVVTALVFELIAITWIYGAKNIYTDLEFSIG-RP-IFRVWMWLWV-IC 647
                 :.:::|:......:|...:|||:.|:::||.:....|:|..|| :| ||  |...|. :.
  Rat   625 QGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIF--WKVCWAFVT 687

  Fly   648 PAILTGILVWWCADDDQYDLL--AEY-LPRWAPILFVLAVIVIIACVQIFRQVEY---------N 700
            |.|||.||   |....|::.:  ..| .|.|:.:|..|    ::||..|:..:.:         .
  Rat   688 PTILTFIL---CFSFYQWEPMTYGSYRYPNWSMVLGWL----MLACSVIWIPIMFVIKMYLAPGR 745

  Fly   701 FFGMICEASKPAKEWGPADPLARHSWKQWRSVCQDTGRRDFTLR 744
            |...:.....|..:|||.  ||:|..::::::....|.....|:
  Rat   746 FIERLKLVCSPQPDWGPF--LAQHRGERYKNMIDPLGTSSLGLK 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	125/558 (22%)
Slc6a5	NP_976079.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64		10/28 (36%)
Slc6a5	NP_976079.1	SLC6sbd_GlyT2	193..789	CDD:271389	145/656 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810