DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment blot and Slc6a4

DIOPT Version :9

Sequence 1:	NP_524125.2	Gene:	blot / 39939	FlyBaseID:	FBgn0027660	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_034614.2	Gene:	Slc6a4 / 15567	MGIID:	96285	Length:	630	Species:	Mus musculus

Alignment Length:	651	Identity:	140/651 - (21%)
Similarity:	235/651 - (36%)	Gaps:	191/651 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 ISSSGIVTLSDSNNTLSEIQGGYHDMDHDAVSKNFSISASAHNITTASNAKLLPAVEDESNKQTK 215
            :...|:.|.:|.... .:|..||     .||....:...:.|: |.|:...|:..:. :..::|.
Mouse    26 VLQKGVPTPADKAGP-GQISNGY-----SAVPSTSAGDEAPHS-TPAATTTLVAEIH-QGERETW 82

  Fly   216 CSVFRGLVLCLCLNLSYANVVRFPRELDRY------GSAYLVPYVVLLFLVGLPMVLLEISVGQF 274
            ......|:..:...:...|:.|||     |      |.|:|:||.::....|:|:..:|:::||:
Mouse    83 GKKMDFLLSVIGYAVDLGNIWRFP-----YICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQY 142

  Fly   275 LGQGAAHTW-RASPIFKG----ACMISRF-ASWLSAI--WVSLQAVLALAYIGMFASNDLPFREC 331
            ...|....| :..|||||    .|:|:.: ||:.:.|  |       ||.|:....::.||:..|
Mouse   143 HRNGCISIWKKICPIFKGIGYAICIIAFYIASYYNTIIAW-------ALYYLISSFTDQLPWTSC 200

  Fly   332 AGPVKL-RLSGYL--------LTGTSGQE----------------------------CLQLTFLT 359
            ...... ..:.|.        |..||..|                            |:.|.|..
Mouse   201 KNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLALCIMLIFTI 265

  Fly   360 PFWRNPLYF----GLLAAGLIGLWIVVMLCTHNAKILRRSIFVFGLVGLVLL--CTLTG-WEVRN 417
                  :||    |:..:|.: :|:.             :.|.:.::.::|:  .||.| |  |.
Mouse   266 ------IYFSIWKGVKTSGKV-VWVT-------------ATFPYIVLSVLLVRGATLPGAW--RG 308

  Fly   418 SFSRHYFPELWGFDSNLLAESNIWFNALMQVLFSVNCGFGALPMIT--GKF---LYKGDAVRTSV 477
            ..  .|....|    ..|.|:.:|.:|..|:.||:..|||.|....  .||   .|: ||:.|||
Mouse   309 VV--FYLKPNW----QKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQ-DALVTSV 366

  Fly   478 VYLCFNLLINAIAVTLFMVQFDLSSNGFQNMEELKPLTAIYDRVLNGSREGDSHLLQHLVPSLI- 541
            |. |....::...:...:        |:  |.|::             .|..|.:.:...|||:
Mouse   367 VN-CMTSFVSGFVIFTVL--------GY--MAEMR-------------NEDVSEVAKDAGPSLLF 407

  Fly   542 --YALIILSAMVSITVAVYTSTRLV---------------------------PRRPNYVI----- 572
              ||..|.:...|...|:.....|:                           .||..:|:
Mouse   408 ITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVIT 472

  Fly   573 CLIGLVVAVISFAAPKFLIARVLDSRLVGTMVVTALVFELIAITWIYGAKNIYTD----LEFSIG 633
            |::|.::.:.|..|   .:..:|:....|..|:|..:.|.:.::|.||.....:|    |.||.|
Mouse   473 CILGSLLTLTSGGA---YVVTLLEEYATGPAVLTVALIEAVVVSWFYGITQFCSDVKEMLGFSPG 534

  Fly   634 RPIFRVWMWLWVIC-----PAILTGILVWWCADDDQYDLLAEYLPRWAPILFVLAVIVIIACVQI 693
                    |.|.||     |..|..|:..:.....|..|.....|.|:.||........:.|:.|
Mouse   535 --------WFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIILGYCIGTSSVICIPI 591

  Fly   694 F 694
            :
Mouse   592 Y 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	119/546 (22%)
Slc6a4	NP_034614.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..63		9/43 (21%)
		5HT_transport_N	24..64	CDD:281488	9/44 (20%)
		SLC6sbd_SERT	79..615	CDD:271399	128/590 (22%)
		Interaction with RAB4A. /evidence=ECO:0000250	616..624
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900