DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment blot and Slc6a20

DIOPT Version :9

Sequence 1:	NP_524125.2	Gene:	blot / 39939	FlyBaseID:	FBgn0027660	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_579830.1	Gene:	Slc6a20 / 113918	RGDID:	621651	Length:	616	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	121/532 - (22%)
Similarity:	215/532 - (40%)	Gaps:	117/532 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 CLCLNLSYANVVRFPRELDRY-GSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQGAAHTWRA-SP 287
            |:...:...||.|||.....| |.::||||:::|.:.|:|::.||::|||.:.||:...||. ||
  Rat    42 CISYAVGLGNVWRFPYLCQMYGGGSFLVPYLIMLIVEGMPLLYLELAVGQRMRQGSIGAWRTISP 106

  Fly   288 IFKGACMISRFASWLSAIWVSLQAVLALAYIGMFASNDLPFRECAGPVKLRLSGYLLTGTSGQEC 352
            ...|..:.|...|:..:::.::.......|:.....:.||:..|  |:....:||      .:||
  Rat   107 YLSGVGVASVVVSFFLSMYYNVINAWGFWYLFHSFQDPLPWSVC--PLNSNRTGY------DEEC 163

  Fly   353 LQLTFLTPFW-RNPLYF--------GLL---AAGLIGLWIVVMLCTHNAKILRRS-----IFVFG 400
            .:.:....|| |..|..        |:.   |..|...|::|.||     |||.:     :..|
  Rat   164 EKASSTQYFWYRKTLNISPSIQENGGVQWEPALCLTLAWLMVYLC-----ILRGTESTGKVVYF- 222

  Fly   401 LVGLVLLCTLTGWEVR--------NSFSRHYFPELWGFDSNLLAESNIWFNALMQVLFSVNCGFG 457
             ..|:..|.|..:.||        |.....:.|::     ..||....|.||..|:.||:..|||
  Rat   223 -TALMPYCVLIIYLVRGLTLHGATNGLMYMFTPKI-----EQLANPKAWINAATQIFFSLGLGFG 281

  Fly   458 ALPMITGKFLYKGDAVRTSVVYLCFNLLINAIA-----------------------VTLFMVQFD 499
            :|...........|..:.:|:....|...:..|                       :.|....||
  Rat   282 SLIAFASYNEPSNDCQKHAVIVSVINSSTSIFASIVTFSIYGFKATFNYENCLNKVILLLTNSFD 346

  Fly   500 LSSNGF---QNMEELKPLTA---------IYDRVLNGSREGD---------------SHLLQHLV 537
            | .:||   .|:||:|...|         ::..:.|.|.|.:               :..::::.
  Rat   347 L-EDGFLTASNLEEVKDYLASTYPNKYSEVFPHIRNCSLESELNTAVQGTGLAFIVYAEAIKNME 410

  Fly   538 PSLIYALII--------LSAMVSITVAVYT--------STRLVPRRPNYVICLIGLVVA-VISFA 585
            .|.:::::.        :.:|:..|.|:.|        |:.|.....:.::|||...|. |.:..
  Rat   411 VSQLWSVLYFFMLLMLGMGSMLGNTAAILTPLTDSKVISSYLPKEAISGLVCLINCAVGMVFTME 475

  Fly   586 APKFLIARVLDSRLVGTMVVTALVFELIAITWIYGAKNIYTDLEFSIGRPIFRVWMWLWV-ICPA 649
            |..:......|.....::::..|| |.||:.::||.:...:||....|||:...|..:|. :.|.
  Rat   476 AGNYWFDIFNDYAATLSLLLIVLV-ETIAVCYVYGLRRFESDLRAMTGRPLNWYWKAMWAFVSPL 539

  Fly   650 ILTGILVWWCAD 661
            ::.|:.:::.:|
  Rat   540 LIIGLFIFYLSD 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	120/528 (23%)
Slc6a20	NP_579830.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
Slc6a20	NP_579830.1	SLC5-6-like_sbd	26..601	CDD:294310	121/532 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910