DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment blot and Slc6a5

DIOPT Version :9

Sequence 1:	NP_524125.2	Gene:	blot / 39939	FlyBaseID:	FBgn0027660	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_006540608.1	Gene:	Slc6a5 / 104245	MGIID:	105090	Length:	831	Species:	Mus musculus

Alignment Length:	819	Identity:	179/819 - (21%)
Similarity:	294/819 - (35%)	Gaps:	254/819 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 ETDL----PTVTPSP-----------QTTRSCISTVSSVVDSGGGRTTATSGR--ISSSGIVTLS 160
            |.||    ||.|..|           ||.:|..:.......||.|....:|.|  .:|:.:..||
Mouse    68 EQDLPAEAPTATVQPPRVPRSASTGAQTFQSADARACEAQQSGVGFCNLSSPRAQATSAALRDLS 132

  Fly   161 DSNNTLSEIQGG--------------YHDMDHDAVSKNFSISASA--HNITTASN---------- 199
            :.::..:....|              ....:.||   |.|:....  ||.|.|..
Mouse   133 EGHSAQANPPSGPAGAGNALHCKIPALRGPEEDA---NVSVGKGTLEHNNTPAVGWVNMSQSTVV 194

  Fly   200 ------AKLLPA-------VEDESNKQTKCSVFRG-------LVLCLCLNLSYA----NVVRFP- 239
                  |.:||.       .|||...:.|.   ||       .:|.:   :.||    ||.|||
Mouse   195 LGTDGIASVLPGSVATTTIPEDEQGDENKA---RGNWSSKLDFILSM---VGYAVGLGNVWRFPY 253

  Fly   240 RELDRYGSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQGAAHTWRASPIFKGACMISRFASWLSA 304
            ......|.|:|:||:::|.|.|||:..||:|:|||..||....|:|.|..:|..:.....|.|.|
Mouse   254 LAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIA 318

  Fly   305 IWVSLQAVLALAYIGMFAS--NDLPFRECAGP------------------------VKLRLSGYL 343
            |:.::.....|.|  :|||  :.||:..|..|                        ::::.|.:.
Mouse   319 IYYNVIICYTLFY--LFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVIGDHPKIQIKNSTFC 381

  Fly   344 LTG-----------------TSGQECLQLTFLTPF-----------WRNPLYFGLLAAGLIGLWI 380
            :|.                 .||.|.....|:...           |  ||.|.|..|     |:
Mouse   382 MTAYPNLTMVNFTSQTNKTFVSGSEEYFKYFVLKISAGIEYPGEIRW--PLAFCLFLA-----WV 439

  Fly   381 VVMLCTHNAKILRRS------IFVFGLVGLVLL----CTLTG-----WEVRNSFSRHYFPELWGF 430
            :|....  ||.::.|      ...|..|.||:|    .||.|     |        ::....|
Mouse   440 IVYASL--AKGIKSSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIW--------YFITPKW-- 492

  Fly   431 DSNLLAESNIWFNALMQVLFSVNCGFGALPMITGKFLYKGDAVRTSVVYLCFNLLINAIAVTLFM 495
              ..|.::.:|.:|..|:.||::..:|.|..::....:..:..|.:::..|.|...:..|..:..
Mouse   493 --EKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIF 555

  Fly   496 VQFDLSSN----GFQNMEELKPLTA--IYDRVLNGSREGDSHLLQHLVPSLIYALIILSAMVSIT 554
            ......:|    ..:|:.:..|..|  :|...|.           .|..|..:|:|....::::.
Mouse   556 SVIGFMANERKVNIENVADQGPGIAFVVYPEALT-----------RLPLSPFWAIIFFLMLLTLG 609

  Fly   555 VAVYTSTRLVPRRPNYVICLIGLVVAVISFAAPKFL----------------------------- 590
            :....:|             |..:|..||...||:|
Mouse   610 LDTMFAT-------------IETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIY 661

  Fly   591 IARVLDSRLVGTMVVTALVFELIAITWIYGAKNIYTDLEFSIG-RP-IFRVWMWLWV-ICPAILT 652
            :.:::|:......:|...:|||:.|:::||.:....|:|..|| :| ||  |...|. :.|.|||
Mouse   662 MFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFKPNIF--WKVCWAFVTPTILT 724

  Fly   653 GILVWWCADDDQYDLL--AEY-LPRWAPILFVLAVIVIIACVQIFRQVEY---------NFFGMI 705
            .||   |....|::.:  ..| .|.|:.:|..|    ::||..|:..:.:         .|...:
Mouse   725 FIL---CFSFYQWEPMTYGSYRYPNWSMVLGWL----MLACSVIWIPIMFVIKMYLAPGRFIERL 782

  Fly   706 CEASKPAKEWGPADPLARHSWKQWRSVCQDTGRRDFTLR 744
            .....|..:|||.  ||:|..::::::....|.....|:
Mouse   783 KLVCSPQPDWGPF--LAQHRGERYKNMIDPLGTSSLGLK 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	125/558 (22%)
Slc6a5	XP_006540608.1	SLC6sbd_GlyT2	225..821	CDD:271389	145/656 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910