DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment blot and Slc6a8

DIOPT Version :9

Sequence 1:	NP_524125.2	Gene:	blot / 39939	FlyBaseID:	FBgn0027660	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_598748.1	Gene:	Slc6a8 / 102857	MGIID:	2147834	Length:	640	Species:	Mus musculus

Alignment Length:	558	Identity:	119/558 - (21%)
Similarity:	199/558 - (35%)	Gaps:	179/558 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 LVLCLCLNLSYANVVRFPRELDRY------GSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQGAA 280
            ::.|:...:...||.|||     |      |..:|:|||::..:.|:|:..||||:|||:..|:.
Mouse    62 IMSCVGFAVGLGNVWRFP-----YLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSI 121

  Fly   281 HTWRASPIFKGACMISRFASWLSAIWVSLQAVLALA----YIGMFASNDLP-------------- 327
            :.|...|:|||.    .:||.:...:.:...::.||    |:....:..||
Mouse   122 NVWNICPLFKGL----GYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCV 182

  Fly   328 --FR--ECAGPVKLRLSGYLLTGTSGQECLQL----TFLTPFWRNP---LYFGLLAAG------- 374
              ||  :||......|:           |.||    :.:..||.|.   |..||...|
Mouse   183 EIFRHEDCANASLANLT-----------CDQLADRRSPVIEFWENKVLRLSTGLEVPGALNWEVT 236

  Fly   375 --LIGLWIVVMLCT-----HNAKILRRS------IFVFGLV-GLVLLCTLTGWEVRNSFSRHYFP 425
              |:..|::|..|.     ...||:..:      :.|..|| |::|...|.|       ..:|..
Mouse   237 LCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDG-------IIYYLK 294

  Fly   426 ELWGFDSNLLAESNIWFNALMQVLFSVNCGFGALPMITGKFLYKGDAVRTSVVYLCFNLLINAIA 490
            ..|    :.|....:|.:|..|:.||...|.|||..:.....:..:..:.:::....|      :
Mouse   295 PDW----SKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALIN------S 349

  Fly   491 VTLFMVQFDL-SSNGFQNMEELKPLTAI-----------YDRVLNGSREGDSHLLQHLVP---SL 540
            .|.|...|.: |..||...|:...::.:           |.|.:.         |..:.|   :|
Mouse   350 GTSFFAGFVVFSILGFMATEQGVHISKVAESGPGLAFIAYPRAVT---------LMPVAPLWAAL 405

  Fly   541 IYALIILSAMVSITVAVYTSTRLVPRRPNYVICLIGLVVAVISFAAPKFL-------IARVLDSR 598
            .:.:::|..:.|..|.|          ..::..|:.|:.|...|...:.:       :..|:|..
Mouse   406 FFFMLLLLGLDSQFVGV----------EGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLS 460

  Fly   599 LV----------------------GTMVVTALVFELIAITWIYGAKNIYTDLEFSIG-RPIFRVW 640
            :|                      ||.::....:|.:.:.|:|||.....|:...|| ||.  .|
Mouse   461 MVTDVSGGKGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPC--PW 523

  Fly   641 M-WLW-VICPAILTGILV------------------WW 658
            | |.| ...|.:..||.:                  ||
Mouse   524 MKWCWSFFTPLVCMGIFIFNIVYYEPLVYNNTYVYPWW 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	119/558 (21%)
Slc6a8	NP_598748.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
Slc6a8	NP_598748.1	SLC6sbd_CT1	52..626	CDD:271397	119/558 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900