DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment blot and slc6a4l

DIOPT Version :9

Sequence 1:	NP_524125.2	Gene:	blot / 39939	FlyBaseID:	FBgn0027660	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_012825214.2	Gene:	slc6a4l / 100496361	XenbaseID:	XB-GENE-981144	Length:	590	Species:	Xenopus tropicalis

Alignment Length:	633	Identity:	139/633 - (21%)
Similarity:	241/633 - (38%)	Gaps:	154/633 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 VSKNFSISASAHNITTASNAKLLPAV--EDESNKQTKCSVFRGLVLCLCLNLSYANVVRFPRELD 243
            |.|:....||..|    :||..||.:  .|..:|.:|...|...|:...::|  .||.|||
Frog    10 VDKHPKQQASTPN----NNAMPLPLITQADSRDKWSKKMDFLLSVIGFAVDL--GNVWRFP---- 64

  Fly   244 RY------GSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQGAAHTW-RASPIFKGACMISRFASW 301
             |      |.|:|:||.::....|:|:..:|:::|||...||...| |..|||||.    .||..
Frog    65 -YICYQNGGGAFLIPYTIMAIFGGVPLFYMELALGQFHRMGAIPIWKRICPIFKGI----GFAIC 124

  Fly   302 LSAIWVSL--QAVLALAYIGMFAS--NDLPFRECAGP------------VKLRLSGYL------- 343
            :.|::||.  ..::|.|....::|  ..||:..|..|            ..:..:.|.
Frog   125 IIALYVSFYYNTIIAWALFYFYSSFTETLPWTNCDNPWNTPNCTNYFGRSNITWNNYSKSPAEEF 189

  Fly   344 -------------LTGTSGQE-----CLQLTFLTPFWRNPLYFGLLAAGLIGLWIVVMLCTHNAK 390
                         |....|..     ||.:.|...::  .|:.|:..:|.: :|:...|
Frog   190 YTRKVLGIHEAEGLDNVGGLRWQLILCLFIIFTIVYF--SLWKGVKTSGKV-VWVTATL------ 245

  Fly   391 ILRRSIFVFGLVGLVLLCTLTG-WEVRNSFSRHYFPELWGFDSNLLAESNIWFNALMQVLFSVNC 454
                 .:|..|:.|:...||.| |  |...  .|....|    ..|.::.:|.:|..|:.||:..
Frog   246 -----PYVVLLILLIRGATLPGAW--RGIL--FYLRPKW----EKLMDTAVWVDAAAQIFFSLGP 297

  Fly   455 GFGALPMITGKFLYKGDAVRTSVVYLCFNLLINAIA-VTLFMVQFDLSSNGFQNMEELKPLTAIY 518
            |||.|..::....:..:..|.:::....|.|.:.:: ..:|.|...::......:|::
Frog   298 GFGVLLALSSYNPFHNNCYRDALITSTVNCLTSFVSGFVIFTVLGYMAEMRGVEVEDV------- 355

  Fly   519 DRVLNGSREGDSHL-------LQHLVPSLIYALIILSAMVSITV--------AVYTSTR------ 562
                 ...:|.|.|       :.::|.|..:|:|....|:::.:        |:.|:..
Frog   356 -----AKDKGPSLLFITYPEAIANMVGSTFFAIIFFLMMITLGLDSTFGGLEAIITAVMDEYPHI 415

  Fly   563 LVPRRPNYVICLIGLVVAVISFAAPKF-----LIARVLDSRLVGTMVVTALVFELIAITWIYGAK 622
            |..||..:|   :|||:...:.:....     .:.::|:....|..::..:..|.||::|.||.:
Frog   416 LSKRRELFV---LGLVIVCFTGSLSTLTYGGAYVVKLLEQFGAGCPIIAVVFLEAIAVSWFYGIQ 477

  Fly   623 NIYTDLEFSIGRPIFRVWMWLWV-ICPAILTGILVWWCADDDQYDLLAEYLPRWA---------- 676
            ....|::..:|......|...|| |.||.|..|:|....|.....|.....|:|.
Frog   478 RFSNDVKSMLGFVPGIFWRICWVAISPAFLAFIIVSSLMDQPPLILFDYQYPKWTVSVGFLIGAS 542

  Fly   677 -----PILFVLAVI--------VIIACVQIFRQVEYNFFGMICEASKP 711
                 |:..|..::        .:..||:..:.|.......:|.||:|
Frog   543 SFIWIPVYMVYKLVWTPGSLKERLAVCVRPEKTVRDQQLDSMCMASEP 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	114/516 (22%)
slc6a4l	XP_012825214.2	SLC5-6-like_sbd	37..573	CDD:382020	124/583 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910