DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment blot and slc6a11b

DIOPT Version :9

Sequence 1:	NP_524125.2	Gene:	blot / 39939	FlyBaseID:	FBgn0027660	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_017213744.2	Gene:	slc6a11b / 100150472	ZFINID:	ZDB-GENE-121116-2	Length:	617	Species:	Danio rerio

Alignment Length:	523	Identity:	116/523 - (22%)
Similarity:	206/523 - (39%)	Gaps:	135/523 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 LSYANVVRFPRELDRY------GSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQGAAHTWR-ASP 287
            :...||.|||     |      |.|:.||||:.....|:|:..||.::|||..:|....|| ..|
Zfish    57 IGLGNVWRFP-----YLCYKNGGGAFFVPYVIFFVCCGIPVFFLETALGQFTSEGGITCWRKVCP 116

  Fly   288 IFKGACMISRFASWLSAIWVSLQAVLALAYIGMFASN----DLPFRECAGPVKLRLSGYLLTGTS 348
            :|:|.    .:|:.:....:::..|:.||:...:..|    :||:..|        ..|..|
Zfish   117 LFEGI----GYATQVIEAHLNVYYVVILAWAIFYLFNCFTTELPWASC--------GHYWNT--- 166

  Fly   349 GQECLQL------TFLTPFWRNPL-----------------YFGL---LAAGLIGLWIVVMLC-- 385
             :.|:..      .|..|:..:|:                 ..||   ||..|...|::...|
Zfish   167 -ENCVDFNNESIANFTNPYSTSPVMEFWERRVLKISSGIEEVGGLRWELALCLAIAWVICYFCIW 230

  Fly   386 ---THNAKILR-RSIFVFGLVGLVLLCTLTGWEVRNSFSRHYFPELWGFDSNLLAESNIWFNALM 446
               ....|::. .:.|.:.::.::||..:|.....|....:.:|     |.:.|::..:|.:|..
Zfish   231 KGPKSTGKVVYVTATFPYFMLLILLLRGITLPGAANGIKFYLYP-----DISRLSDPQVWVDAGT 290

  Fly   447 QVLFSVNCGFGALPMITGKFLYKGDAVRTSVVYLCFNLLINAIAVTLFMVQFDL-SSNGFQNMEE 510
            |:.||.....|.|..:.....|..:..|..::..|.|      :.|.|:..|.: |..||...|:
Zfish   291 QIFFSYAICLGCLTALGSYNSYNNNCYRDCLMLCCLN------SGTSFVAGFAIFSVLGFMAYEQ 349

  Fly   511 LKPLTAI-----------YDRVLNGSREGDSHLLQHLVP------SLIYALII----------LS 548
            ..|:.|:           |.:.:.            ::|      :|.:.::|          :.
Zfish   350 NVPIEAVAESGPGLAFIAYPKAVT------------MMPWAPLWAALFFMMLIFLGLDSQFVCVE 402

  Fly   549 AMVSITVAVYTSTRLVPRRPNYVICLIGLVVA-----VISFAAPKFLIARVLDSRLV-GTMVVTA 607
            ::|:..|.:|..|..|..|...:|  :|:.:|     :|........:.::.||... |..::..
Zfish   403 SLVTAIVDMYPKTFRVGYRRELLI--LGMSIASFFLGLIMLTEGGMYVFQLFDSYAASGMCLLFV 465

  Fly   608 LVFELIAITWIYGAKNIYTDLEFSIG-RPIFRV-WMWLWVICPAILTGILVWWCADDDQYDLLAE 670
            .:||.|.|.|:||:...|.::|..|| :|||.: |.|.: ..|.|.|||.:::         |.:
Zfish   466 AIFESICIGWVYGSDRFYLNIEDMIGYKPIFFIKWCWKF-FTPGICTGIFLFF---------LIK 520

  Fly   671 YLP 673
            |.|
Zfish   521 YKP 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	113/507 (22%)
slc6a11b	XP_017213744.2	SLC5-6-like_sbd	38..576	CDD:320982	116/523 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910