DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad74A and CELSR1

DIOPT Version :10

Sequence 1:NP_648973.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:NP_001365257.1 Gene:CELSR1 / 9620 HGNCID:1850 Length:3019 Species:Homo sapiens


Alignment Length:1671 Identity:392/1671 - (23%)
Similarity:614/1671 - (36%) Gaps:517/1671 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   242 PPIFTNAP--------------------------YSATVPENTPAGVSILTVKA---VDGDVGIP 277
            ||:..|.|                          |...:.||.|||..||.:.|   ::|:....
Human   216 PPLPPNLPEARAGPARRARRGTSGRGSLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERV 280

  Fly   278 REIFLSLEDE-PFGHFELVPFGDPRDGTAVLQTTSEPLDRENAEILQNGGVYVFSIRATELIDGA 341
            ......|.|| ..|:|.:       |......:|...||||..|      .:|..::|   :|.:
Human   281 SYYMEGLFDERSRGYFRI-------DSATGAVSTDSVLDRETKE------THVLRVKA---VDYS 329

  Fly   342 IPAEHSLTRVTIVVTDVDDHQPTFSGPHFNVSITENLANGMPLPGLSIFVDDRD--MGENSRYEL 404
            .|...:.|.:|::|.|.:||.|.|....:...:.|||..|..:  |:|...|||  :..|.||  
Human   330 TPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEV--LTIRASDRDSPINANLRY-- 390

  Fly   405 SLRDVFNAARVFEVSPTESQGRTPVVVKVLNASRLDYDVVDPDLRKFEFDLVASVK------GVE 463
              |.:..|..||:::  ||.|      .|...:.||.:      ...|:.|:....      |..
Human   391 --RVLGGAWDVFQLN--ESSG------VVSTRAVLDRE------EAAEYQLLVEANDQGRNPGPL 439

  Fly   464 KAKTRVEIHLLDANDNAPVFDQGTYRFTAAENLPVDAIIGHVKATDLDSGEFGHVRY-VLKGFGA 527
            .|...|.|.:.|.|||.|.|.:..|.....|::.::..:..|:|||.|.|:...:.| :|.|..|
Human   440 SATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVA 504

  Fly   528 DNFYVNPETGGVYLLKPLDYEKQSSYSLTVVAIDGGQR---EANANLFVGVTDVNDNHPNFESKE 589
            ..||::..:|.:.::.|||:|....|||::.|.|||:.   .::..:.|.|.|||||.|.|.|..
Human   505 GQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSP 569

  Fly   590 YSRTIREGAALFEPQFFVRAHDADGPSQGNGRVKYSIVSENS--IAGN-------------VFRI 639
            :..|:.|...|..|...::|.|||  |..|.|:.|.:|...|  :.|.             .|:|
Human   570 FQATVLENVPLGYPVVHIQAVDAD--SGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQI 632

  Fly   640 EPDTGEIVIQKAARSMDTERGE-YELVVSATDFGIPPLSNTTRVLVRVGISGNQRPIFRGHFQNM 703
            ...:|.|.:   ...:|.|..| |...|.|.|.|.||:|::|.|.:.| :..|            
Human   633 HNSSGWITV---CAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITV-LDVN------------ 681

  Fly   704 ENLPIIGPPSYRVSIPENAAAGSNVTSVSAHDPDGLDSLLRYRIVGAN--DNFEIDEI--SGLIT 764
            :|.|:...|:|.:.:.|:||.||:|.::.|.|.|. :|::.|::.|.|  :.|.:...  .||||
Human   682 DNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDA-NSVITYQLTGGNTRNRFALSSQRGGGLIT 745

  Fly   765 VSPQARIDRDSNMNSFEIIVNAVDSGTPIPETATTTVYVNVKDINDERPKFEQNSYATYVSERTA 829
            ::    :..|.......::......||   .:.|..|.:||.|.|..||.|:.:.|...|||...
Human   746 LA----LPLDYKQEQQYVLAVTASDGT---RSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRP 803

  Fly   830 VGESVLRVKAIDKDL--NSKLEYSMVGPVAATTKAGVSIANRSNYRLQEAFRVDSQSGEIFVNGT 892
            ||.|:..:.|.|:|.  |:::.|.:..||                   ..||:|..||.::.   
Human   804 VGTSIATLSANDEDTGENARITYVIQDPV-------------------PQFRIDPDSGTMYT--- 846

  Fly   893 LRHDVAAIIIFTVGVRDLNAEVDPEGQVDTTEVTVYVQSFQDTNPVFKNTGWTSSRPVIDVKIKE 957
                              ..|:|.|.||..| :|:..|                           
Human   847 ------------------MMELDYENQVAYT-LTIMAQ--------------------------- 865

  Fly   958 EMPIDSALFILQAEDPVTRQPITSFELIEPKQVDYFQVAERTGEVILKKRLDYEALGDTG-PEFE 1021
                                                                     |.| |   
Human   866 ---------------------------------------------------------DNGIP--- 870

  Fly  1022 LQVRANSADRQRSTVSRVNITVENVNDNSPRFERNSYQATIIENRPHPERVIRVRALDKDAVLNA 1086
                      |:|..:.:.|.:.:.|||:|:|..:.||.:|.|:.|....:::|.|.|:|:..|.
Human   871 ----------QKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNG 925

  Fly  1087 RDERLGYHKIIYSLQG--EHAMLFDINNTTGEIIVASGQTIDRERTPRIQLQIKAEDSPGRPTDA 1149
            |        ::|:.||  :....|.|..|:|  ::.:.:.:|||......|...|.|. |.||..
Human   926 R--------LLYTFQGGDDGDGDFYIEPTSG--VIRTQRRLDRENVAVYNLWALAVDR-GSPTPL 979

  Fly  1150 KQSVVELQIEVLDVNDNAPEFTQKKYSTVIPENAQIDSFVLQLEAVDADEGLGGEVRYELVNEGE 1214
            ..| ||:|:.:||:|||||.|.:.:....:.||..:.|.|.::.|.|.|||...::.|::| ||:
Human   980 SAS-VEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV-EGD 1042

  Fly  1215 ANGLFKIDTKSGLISTRRNLTGKGRAHPYVLIVRAQDNGNQMPKQPTLSTDTDVRIYIGDVSAND 1279
            ....|::|..:|.:.....|..:.| ..|||:|:|       ...|.:|..|   ::|..|..||
Human  1043 MRHFFQLDLLNGDLRAMVELDFEVR-REYVLVVQA-------TSAPLVSRAT---VHILLVDQND 1096

  Fly  1280 GVPYFLSPRV---GQMANVTENAVTGAPVFQVIASDPDDESTPSGTITYRILPDTPDAEAFVIDA 1341
            ..|.....::   ..:.|.:.:..||. :..:.|.|||    .|.::.|..:... :....::|.
Human  1097 NPPVLPDFQILFNNYVTNKSNSFPTGV-IGCIPAHDPD----VSDSLNYTFVQGN-ELRLLLLDP 1155

  Fly  1342 HSGLITTRQSMDRETKDMYRILLEVS-DNGQPKQSATRILQIAILDVDD-------------HEP 1392
            .:|.:  :.|.|.:.......|:||| .:|....:|...|::.|: .||             .:.
Human  1156 ATGEL--QLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTII-TDDMLTNSITVRLENMSQE 1217

  Fly  1393 RFAR-------EADAGPLS--------MSVREEEPAGTIVGN--FSAL-----------DEDLGE 1429
            :|..       |..|..||        .:|:.:....:.:.|  ||||           .|||  
Human  1218 KFLSPLLALFVEGVAAVLSTTKDDVFVFNVQNDTDVSSNILNVTFSALLPGGVRGQFFPSEDL-- 1280

  Fly  1430 NAAIDYVIIDGNNEQLFTIERNNESLAILKTKK--PID-----REQVESFTLTIKCLKLGEPGYK 1487
                        .||::.   |...|..:.|::  |.|     ||..|::   :||         
Human  1281 ------------QEQIYL---NRTLLTTISTQRVLPFDDNICLREPCENY---MKC--------- 1318

  Fly  1488 FIGDPYDRQDLSHLRINVRVLDIDDNLP-------KFEQPDPTVGIRINVPI----DTVVTTLKA 1541
                             |.||..|.:.|       .|....|..|:|...|.    |...|.:..
Human  1319 -----------------VSVLRFDSSAPFLSSTTVLFRPIHPINGLRCRCPPGFTGDYCETEIDL 1366

  Fly  1542 SDADAEAPPVGLSIENVTFVPQFYKRSRSLAVGNLHNLFTLNNRTGE---------------LRT 1591
            ..:|    |.|.:           .|.||...|.....|  .:.|||               .:.
Human  1367 CYSD----PCGAN-----------GRCRSREGGYTCECF--EDFTGEHCEVDARSGRCANGVCKN 1414

  Fly  1592 GGSFADYVDGYFLMRVMANNSVQPKRQAHSNLKVFVIRDKSLLKFVFARPPNEIQHNIRPFQEQL 1656
            ||:..:.:.|.|                |.                 ..||.|.:   ||:.|..
Human  1415 GGTCVNLLIGGF----------------HC-----------------VCPPGEYE---RPYCEVT 1443

  Fly  1657 QKKLKP--------LGLELHVLDTQVFTRPDMSLDFTATSSCFQMFKNGAAL---SFNEMQKLMN 1710
            .:...|        |....|      ||   :||.| ||..     :||..|   .|||....  
Human  1444 TRSFPPQSFVTFRGLRQRFH------FT---ISLTF-ATQE-----RNGLLLYNGRFNEKHDF-- 1491

  Fly  1711 SQQLRQELID--IYAAYGVSEVESCSVRRTHAAAIFAGMLTSAGAW 1754
               :..|::|  :...:...|..:     |.|..:.:|:  |.|.|
Human  1492 ---IALEIVDEQVQLTFSAGETTT-----TVAPKVPSGV--SDGRW 1527

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_648973.1 Cadherin_repeat 33..124 CDD:206637
Cadherin_repeat 132..240 CDD:206637
Cadherin_repeat 249..361 CDD:206637 31/141 (22%)
Cadherin_repeat 487..581 CDD:206637 31/97 (32%)
Cadherin_repeat 589..686 CDD:206637 32/112 (29%)
Cadherin_repeat 713..810 CDD:206637 27/100 (27%)
Cadherin_repeat 819..936 CDD:206637 27/118 (23%)
Cadherin_repeat 953..1049 CDD:206637 7/96 (7%)
Cadherin_repeat 1057..1166 CDD:206637 34/110 (31%)
Cadherin_repeat 1175..1279 CDD:206637 28/103 (27%)
Cadherin_repeat 1293..1390 CDD:206637 23/110 (21%)
Cadherin_repeat 1402..1513 CDD:206637 27/138 (20%)
Cadherin_repeat 1523..1628 CDD:206637 21/123 (17%)
CELSR1NP_001365257.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 205..242 4/25 (16%)
Cadherin_repeat 250..349 CDD:206637 30/114 (26%)
Cadherin_repeat 357..455 CDD:206637 30/117 (26%)
Cadherin_repeat 464..561 CDD:206637 31/96 (32%)
Cadherin_repeat 569..683 CDD:206637 34/131 (26%)
Cadherin_repeat 691..785 CDD:206637 28/101 (28%)
Cadherin_repeat 793..888 CDD:206637 34/232 (15%)
Cadherin_repeat 897..995 CDD:206637 34/109 (31%)
Cadherin_repeat 1003..1097 CDD:206637 29/105 (28%)
Cadherin_repeat 1117..1198 CDD:206637 19/88 (22%)
EGF_CA 1364..1399 CDD:238011 11/51 (22%)
EGF_CA 1407..1441 CDD:238011 10/69 (14%)
LamG 1444..1627 CDD:238058 25/111 (23%)
EGF_CA 1651..1685 CDD:238011
Laminin_G_2 1719..1849 CDD:460494
EGF_CA 1874..1908 CDD:238011
TNFRSF 1881..2011 CDD:473981
CRD2 1898..1934 CDD:276930
EGF_Lam 2002..>2040 CDD:238012
HormR 2052..2113 CDD:214468
GAIN 2130..2381 CDD:465137
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2291..2328
GPS 2407..2460 CDD:197639
GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098 2411..2461
7tm_GPCRs 2465..2718 CDD:475119
TM helix 1 2468..2492 CDD:320657
TM helix 2 2501..2522 CDD:320657
TM helix 3 2532..2554 CDD:320657
TM helix 4 2573..2589 CDD:320657
TM helix 5 2608..2631 CDD:320657
TM helix 6 2654..2676 CDD:320657
TM helix 7 2680..2705 CDD:320657
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2777..2939
Blue background indicates that the domain is not in the aligned region.

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