DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad74A and Fat1

DIOPT Version :9

Sequence 1:NP_001246814.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:XP_017455748.1 Gene:Fat1 / 83720 RGDID:621254 Length:4624 Species:Rattus norvegicus


Alignment Length:1869 Identity:486/1869 - (26%)
Similarity:794/1869 - (42%) Gaps:408/1869 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 SLSENTPVGSPVFQLKGTDPEGGRLKYSISGP--VFSVDRETGVVRLRQ-ELDRETQDTVEVIIS 96
            :|:..|.:|:|:     .:|    |.|.|..|  .|.:...:||:.... ..|||.|:|..|::.
  Rat  2021 TLAVITAIGNPI-----NEP----LFYRILNPDRRFKISHTSGVLSTTGIPFDREQQETFVVVVE 2076

  Fly    97 ITDEGIYGTEPNTVSQRRV-IPVRDYNDNQPTFLGRPYTASVSESLPVGSELSVEPPIVVVDRDE 160
            :|.|    .||:.|:...| :.|.|.|||.|.|:..||.|.|.....||   .|...:..:|||.
  Rat  2077 VTKE----REPSAVAHVVVKVTVEDQNDNAPVFVNLPYYAVVKVDAEVG---HVIRHVTAIDRDS 2134

  Fly   161 GINSEVQMKCLEENDICDIFEVRAVKISDGNYTARVALKQQLDFES-RPSYILTISASDSALDNR 224
            |.|.:|.....|.:   |.||:        ..:..::||:|.:.:: ...|::|:.|.|.. :..
  Rat  2135 GRNGDVHYYLKEHH---DHFEI--------GPSGDISLKKQFEHDTLNKEYLVTVVAKDGG-NPA 2187

  Fly   225 LSSLATISINVIDIQDQPPIFTNAPYSATVPENTPAGVSILTVKAVDGDVGIPREIFLSLED-EP 288
            .|:...:.|.|::  ...|:|..|.|||.:|||......::.|:| :...|:  ::|.|:.| :|
  Rat  2188 FSAEVLVPITVMN--KAMPVFEKAFYSAEIPENVQTHSPVVHVQA-NSPEGL--KVFYSITDGDP 2247

  Fly   289 FGHFELVPFGDPRDGTAVLQTTSEPLDRENAEILQNGGVYVFSIRATELIDGAIPAEHSLTRVTI 353
            |..|.:      ...|.|:...: |||.|:..      .|..|||||:.:.||    |:...|.|
  Rat  2248 FSQFTI------NFNTGVINVIA-PLDFESHP------AYKLSIRATDSLTGA----HAEVFVDI 2295

  Fly   354 VVTDVDDHQPTFSGPHFNVSITENLANGMPLPGLSIFVDDRD-----------MGENSR------ 401
            ||.|::|:.|.|....::.:::|....|.|:  |.:...|.|           :|.:|:      
  Rat  2296 VVEDINDNPPVFVQQSYSTTLSEASVIGAPI--LQVRATDSDSEPNRGISYQLIGNHSKSHDHFH 2358

  Fly   402 ---------------YE--------------------------LSLRDVFNAARVFE-------V 418
                           ||                          :.:.|:.:...:||       :
  Rat  2359 IDSHTGLISLVRALDYEQFQQHKLLVRAVDGGMPPLSSDVVVTVDVTDLNDNPPLFEQQVYEARI 2423

  Fly   419 SPTESQGRTPVVVKVLNASRLDYD---------------VVDPD-------------LRKFEFDL 455
            |...:.|...:.||..:|.|.|.|               |:|.:             |:.| :.|
  Rat  2424 SEHAAHGHFVMCVKACDADRSDLDRLEYSILSGNDHKSFVIDGETGIITLSNPRRHTLKPF-YSL 2487

  Fly   456 VASVK-GVEKAKTRVEIHLLDANDNAPVFDQGTYRFTAAENLPVDAIIGHVKATDLDSGEFGHVR 519
            ..||. ||.::..||.:.::..|.::|||.|..|....|||.|:..::..|||||.|||.:||:.
  Rat  2488 NVSVSDGVFRSSARVNVTVMGGNLHSPVFHQNEYEVELAENAPLHTLVVQVKATDRDSGIYGHLT 2552

  Fly   520 Y-VLKGFGADNFYVNPETGGVYLLKPLDYE--KQSSYSLTVVAIDGGQREANANLFVGVTDVNDN 581
            | ::..|..|.|||| :.|.|:.|:.||.|  .:...|:.::|.|.|.:.|...:.|.:||.|||
  Rat  2553 YHLVNDFAKDRFYVN-DGGQVFTLERLDREAPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDN 2616

  Fly   582 HPNFESKEYSRTIREGAALFEPQFFVRAHDADGPSQGNGRVKYSIVSENSIAGNVFRIEPDTGEI 646
            .|.|.|.:|...:...||.......|.|.|||..|  |..|.|:|.:::........|...||.|
  Rat  2617 APQFRSTKYEVNVGSSAAKGTSVVKVFASDADEGS--NADVTYAIEADSESVEENLEINQLTGLI 2679

  Fly   647 VIQKAARSMDTERGEYELVVSATDFGIPPLSNTTRVLVRVGISGNQRPIFRGHFQNMENLPIIGP 711
            ..:::...::.|  .:...|.|.|.|.||..:...|.|::             ......||....
  Rat  2680 TTKESLIGLENE--FFTFFVRAVDNGSPPKESVVPVYVKI-------------LPPEVQLPRFSE 2729

  Fly   712 PSYRVSIPENAAAGSNVTSVSA-HDPDGLDSLLRYRIVGAN--DNFEIDEISGLITVSPQARIDR 773
            |.|..||.|:...|:.:..:.. |....|.:|::.....:|  :.|.||..||.:.:  :..:|.
  Rat  2730 PFYTYSISEDMPIGTEIDLIRVEHSGTVLYTLVKGNTPESNRDEFFVIDRQSGRLKL--EKSLDH 2792

  Fly   774 DS------------NMNSFEIIVNAVDSGTPIPETATTTVYVNVKDINDERPKFEQNSYATYVSE 826
            ::            .::.:|::             |:..|.:.|||.||..|..|.|.|..::.|
  Rat  2793 ETTKWYQFSILARCTLDDYEVV-------------ASIDVSIQVKDANDNSPVLESNPYEAFIVE 2844

  Fly   827 RTAVGESVLRVKAIDKD--LNSKLEYSMVGPVAATTKAGVSIANRSNYRLQEAFRVDSQSGEIFV 889
            ....|..|::|:|.|.|  :|.::.|              |:....:..:.|:|.::.::|.|..
  Rat  2845 NLPAGSRVIQVRASDLDSGVNGQVMY--------------SLDQSQDADIIESFAINMETGWITT 2895

  Fly   890 NGTLRHDVAAIIIFTVGVRDLNAEVDPEGQVDTTE-VTVYVQSFQDTNP-----VFKNTGWTSSR 948
            ...|.|:..|.....|...|...:|    |:.:|. |.|.|....|:.|     ::|.|      
  Rat  2896 LKELDHEERASYQIKVVASDHGEKV----QLSSTAIVDVTVTDVNDSPPRFTAEIYKGT------ 2950

  Fly   949 PVIDVKIKEEMPIDSALFILQAEDPVTRQPITSFELIEPKQVDYF--------QVA----ERTGE 1001
                  :.|:.|....:.||...|      ..|.|:  .:||.||        |.|    :....
  Rat  2951 ------VSEDDPPGGVIAILSTTD------ADSEEI--NRQVSYFITGGDALGQFAVENMQNDWR 3001

  Fly  1002 VILKKRLDYEALGDTGPEFELQVRANSADRQRSTVSRVNITVENVNDNSPRFERNSYQATIIENR 1066
            |.:||.||.|    ....:.|.|.|  .|...|:.:||.:.|.:.|||||..||.:|...|.|:.
  Rat  3002 VYVKKPLDRE----QKDSYLLTVTA--TDGTFSSKARVEVKVLDANDNSPVCERTAYSDAIPEDA 3060

  Fly  1067 PHPERVIRVRALDKDAVLNARDERLGYHKIIYSLQGEHAMLFDINNTTGEIIVASGQTIDRERTP 1131
            ...:.|::|.|.|.|...||        :|.|:|.|..|..|.:|..|||:...:  .:|||...
  Rat  3061 LPGKLVMQVSATDADIRSNA--------EITYTLFGSGAEKFKLNPDTGELRTLA--LLDREEQA 3115

  Fly  1132 RIQLQIKAEDSPGRPTDAKQSVVELQIEVLDVNDNAPEFTQKKYSTVIPENAQIDSFVLQLEAVD 1196
            ...|.:||.|..||   :.|:.:.|.:|  |||||.||||...|:..:.||.:..:.:.:::|.|
  Rat  3116 VYHLLVKATDGGGR---SCQATIVLTLE--DVNDNTPEFTADPYAITVFENTEPGTPLTRVQATD 3175

  Fly  1197 ADEGLGGEVRYELVNEGEANGLFKIDTKSGLISTRRNLTGKGRAHPYVLIVRAQDNGNQMPKQPT 1261
            ||.||..::.|.|::  .|:|.|.|:.:||::...::|..:.:| .|.|.::|.|.|  :|::.|
  Rat  3176 ADAGLNRKISYSLLD--SADGQFSINEQSGILQLEKHLDRELQA-VYTLTLKAADQG--LPRKLT 3235

  Fly  1262 LSTDTDVRIYIGDVSANDGVPYFLSPRVGQMANVTENAVTGAPVFQVIASDPDDESTPSGTITYR 1326
             :|.|   :.:..:..||..|.|.....|  |.|:|:.|.|..|.||.|:..|.|:  :..|||.
  Rat  3236 -ATGT---VVVSVLDINDNPPVFEYREYG--ATVSEDIVIGTEVLQVYAASRDIEA--NAEITYA 3292

  Fly  1327 ILPDTPDAEAFVIDAHSGLITTRQSMDRETKDMYRILLEVSDNGQPKQSATRILQIAILDVDDHE 1391
            |:......: |.||:.:|.|...:::|.|:...|.:.:|.:|.|.|..|....:.|.|.|::|:.
  Rat  3293 IISGNEHGK-FSIDSKTGAIFIIENLDYESSHGYYLTVEATDGGTPSLSDVATVNINITDINDNS 3356

  Fly  1392 PRFAREADAGPLSMSVREEEPAGTIVGNFSALDEDLGENAAIDYVIIDGNNEQLFTIE--RNNES 1454
            |.|::::....:|.....|:|..||:.:    |.|...|:.|.|.||:||....|||:  |..  
  Rat  3357 PVFSQDSYTTVVSEDAALEQPVITIMAD----DADGPSNSHILYSIIEGNQGSPFTIDPVRGE-- 3415

  Fly  1455 LAILKTKKPIDREQVESFTLTIKCLKLGEPGYKFIGDPYDRQDLSHLRINVRVLDIDDNLPKFEQ 1519
               :|..||:|||.:..:|||::....|.|           ..::...:|:.|.|::||.|.|.:
  Rat  3416 ---IKVTKPLDRETISGYTLTVQAADNGNP-----------PRVNTTTVNIDVSDVNDNAPLFSR 3466

  Fly  1520 PDPTVGIRINVPIDTVVTTLKASDADA--EAPPVGLSIENVTFVPQFYKRSRSLAVGNLHNLFTL 1582
            .:.:|.|:.|.|:...|..|..:|.|:  ..||...:|.:                ||..|:|.:
  Rat  3467 DNYSVIIQENKPVGFSVLKLVVTDKDSSHNGPPFSFAIVS----------------GNDDNMFEV 3515

  Fly  1583 NNRTGELRTGGSFADYVDGYFLMRVMANNSVQPKRQAHSNLKVFVIRDKSLLKFVFARPPNEIQH 1647
            |.. |.|.|..:....|..::|:.|...::.:|:..:.:::.:.||.:.       ..||     
  Rat  3516 NQH-GVLLTAATVKRKVKDHYLLHVKVADNGKPQLSSLTHIDIRVIEES-------IHPP----- 3567

  Fly  1648 NIRPFQEQLQKKLKPLGL---------------ELHVLDTQVFTRPDMSLD------FTATSSCF 1691
                       .:.||.:               ::|..|..|:.....|||      |:.:|:  
  Rat  3568 -----------AILPLEIFITASGEEYSGGVIGKIHATDQDVYDTLTYSLDPHMDGLFSVSST-- 3619

  Fly  1692 QMFKNGAALSFNEM---QKLMN-----------------SQQLRQELID 1720
                .|..::..::   |.|:|                 .||:.||:::
  Rat  3620 ----GGKLIAHRKLDIGQYLLNVSVTDGKFTTVADITVHIQQVTQEMLN 3664

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_001246814.1 Cadherin_repeat 33..124 CDD:206637 27/92 (29%)
Cadherin_repeat 132..240 CDD:206637 27/108 (25%)
Cadherin_repeat 249..361 CDD:206637 35/112 (31%)
Cadherin_repeat 369..479 CDD:206637 33/203 (16%)
Cadherin_repeat 487..581 CDD:206637 37/96 (39%)
Cadherin_repeat 589..686 CDD:206637 26/96 (27%)
Cadherin_repeat 713..810 CDD:206637 21/111 (19%)
Cadherin_repeat 819..936 CDD:206637 27/119 (23%)
Cadherin_repeat 953..1049 CDD:206637 28/107 (26%)
Cadherin_repeat 1057..1166 CDD:206637 35/108 (32%)
Cadherin_repeat 1175..1279 CDD:206637 28/103 (27%)
Cadherin_repeat 1293..1390 CDD:206637 31/96 (32%)
Cadherin_repeat 1402..1513 CDD:206637 32/112 (29%)
Cadherin_repeat 1523..1628 CDD:206637 23/106 (22%)
Fat1XP_017455748.1 Cadherin_repeat 39..145 CDD:206637
Cadherin_repeat 154..253 CDD:206637
Cadherin 278..357 CDD:421759
Cadherin_repeat 372..>444 CDD:206637
Cadherin_repeat 468..566 CDD:206637
Cadherin_repeat 576..663 CDD:206637
Cadherin_repeat 725..819 CDD:206637
Cadherin_repeat 827..924 CDD:206637
Cadherin_repeat 932..1016 CDD:206637
Cadherin_repeat 1043..1136 CDD:206637
Cadherin_repeat 1144..1242 CDD:206637
Cadherin_repeat 1251..1345 CDD:206637
Cadherin_repeat 1363..1476 CDD:206637
Cadherin_repeat 1485..1582 CDD:206637
Cadherin_repeat 1590..1686 CDD:206637
Cadherin_repeat 1695..1785 CDD:206637
Cadherin_repeat 1793..1898 CDD:206637
Cadherin_repeat 1919..1994 CDD:206637
Cadherin_repeat 2008..2101 CDD:206637 27/92 (29%)
Cadherin_repeat 2109..2198 CDD:206637 26/103 (25%)
Cadherin_repeat 2211..2303 CDD:206637 35/111 (32%)
Cadherin_repeat 2311..2410 CDD:206637 11/100 (11%)
Cadherin_repeat 2418..2512 CDD:206637 20/94 (21%)
Cadherin_repeat 2520..2616 CDD:206637 37/96 (39%)
Cadherin_repeat 2625..2718 CDD:206637 26/109 (24%)
Cadherin_repeat 2732..2829 CDD:206637 22/111 (20%)
Cadherin_repeat 2837..2937 CDD:206637 26/117 (22%)
Cadherin_repeat 2946..3043 CDD:206637 30/122 (25%)
Cadherin_repeat 3056..3145 CDD:206637 34/103 (33%)
Cadherin_repeat 3153..3250 CDD:206637 29/105 (28%)
Cadherin_repeat 3258..3355 CDD:206637 32/101 (32%)
Cadherin_repeat 3363..3460 CDD:206637 32/116 (28%)
Cadherin_repeat 3469..3560 CDD:206637 23/107 (21%)
Cadherin_repeat 3585..3658 CDD:206637 13/78 (17%)
LamG 3878..4009 CDD:214598
EGF_CA 4040..4074 CDD:238011
EGF_CA 4077..4112 CDD:238011
EGF 4117..4147 CDD:394967
EGF_CA 4151..4187 CDD:238011
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24026
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
33.010

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