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Protein Alignment Cad74A and Celsr3

DIOPT Version :9

Sequence 1:	NP_001246814.1	Gene:	Cad74A / 39936	FlyBaseID:	FBgn0036715	Length:	1820	Species:	Drosophila melanogaster
Sequence 2:	NP_112610.1	Gene:	Celsr3 / 83466	RGDID:	621787	Length:	3313	Species:	Rattus norvegicus

Alignment Length:	1265	Identity:	342/1265 - (27%)
Similarity:	539/1265 - (42%)	Gaps:	253/1265 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   360 DHQPTFSGPHFNVSITENLANGMPLPGLSIFVDDRDMGENSRYELSLRDVFN--AARVFEVSPTE 422
            :..|.|...::...:.||.|.|..:  |.:...|.|.||..|...||..:.|  :..:|.:.|..
  Rat   311 NRHPQFPQYNYQTLVPENEAAGTAV--LRVVAQDPDPGEAGRLVYSLAALMNSRSLELFSIDPQS 373

  Fly   423 SQGRTPVVVKVLNASRLDYDVVDPDLRKFEFDLVASVKGVEK--AKTRVEIHLLDANDNAPVFDQ 485
            ...||        |:.||.:    .:.:....:.|...|..:  |.|.|.:.:.|.||:||||:|
  Rat   374 GLIRT--------AAALDRE----SMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHAPVFEQ 426

  Fly   486 GTYRFTAAENLPVDAIIGHVKATDLDSGEFGHVRYVLKG------FGADNFYVNPETGGVYLLKP 544
            ..||.|..||:.....|..::|||.|:....::||...|      ..|..|.::|.:|.:.....
  Rat   427 AQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGSPAARTAAAAAFEIDPRSGLISTSGR 491

  Fly   545 LDYEKQSSYSLTVVAIDGGQ----REANANLFVGVTDVNDNHPNFESKEYSRTIREGAALFEPQF 605
            :|.|...||.|.|.|.|.||    |.|...:.:.|.|.|||.|.|..|.|...:||.........
  Rat   492 VDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVL 556

  Fly   606 FVRAHDADGPSQGNGRVKYSIVSENSIAGNVFRIEPDTGEIVIQKAARSMDTERGEYELVVSATD 670
            .|.|.|.|  ...||.|.|:|:|.|| .|: |.|:..||||.:. |....:.|| ||.|.:.|.|
  Rat   557 RVTATDKD--KDANGLVHYNIISGNS-RGH-FAIDSLTGEIQVM-APLDFEAER-EYALRIRAQD 615

  Fly   671 FGIPPLSNTTRVL-VRVGISGNQRPIFRGHFQNMENLPIIGPPSYRVSIPENAAAGSNVTSVSAH 734
            .|.|||||.|.:. ::|....:..|||            :..| ::||:.|||..|.:|..:.|.
  Rat   616 AGRPPLSNNTGLASIQVVDINDHSPIF------------VSTP-FQVSVLENAPLGHSVIHIQAV 667

  Fly   735 DPD-GLDSLLRYRIVG-ANDN-FEIDEISGLITVSPQARIDRDSNMNSFEIIVNAVDSGTPIPET 796
            |.| |.:|.|.|.:.| |:|. |.|:..:|.::||  ..:||:| :..:...|.|.|.|:| |.:
  Rat   668 DADHGENSRLEYSLTGVASDTPFVINSATGWVSVS--GPLDRES-VEHYFFGVEARDHGSP-PLS 728

  Fly   797 ATTTVYVNVKDINDERPKFEQNSYATYVSERTAVGESVLRVKAIDKDLNSKLEYSMVG-----PV 856
            |:.:|.|.|.|:||.||:|....|...::|..|||.||:.|.|:|:|.||.:.|.:.|     ..
  Rat   729 ASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRF 793

  Fly   857 AATTKAG---VSIANRSNYRLQEAFRVDSQSGEIFVNGTLRHDVAAIIIFTVGVRDLNAEVDPEG 918
            |.:|:.|   |::|...:|:.:..|:                     ::.|...|.|:
  Rat   794 AISTQGGMGLVTLALPLDYKQERYFK---------------------LVLTASDRALH------- 830

  Fly   919 QVDTTEVTVYVQSFQDTNPVFKNTGWTSSRPVIDVKIKEEMPIDSALFILQAEDPVTRQPITSFE 983
              |...|.:.:.......|||::..::       |.:.|:.|:.|.:.::.|.|....:......
  Rat   831 --DHCYVHINITDANTHRPVFQSAHYS-------VSMNEDRPVGSTVVVISASDDDVGENARITY 886

  Fly   984 LIEPKQVDYFQVAERTGEVILKKRLDYEALGDTGPEFELQVRA-NSADRQRSTVSRVNITVENVN 1047
            |:| ..:..|::...:|.:.|:..||||    ....:.|.:.| ::...|::..:.|.:.|.:||
  Rat   887 LLE-DNLPQFRIDADSGAITLQAPLDYE----DQVTYTLAITARDNGIPQKADTTYVEVMVNDVN 946

  Fly  1048 DNSPRFERNSYQATIIENRPHPERVIRVRALDKDAVLNARDERLGYHKIIYSLQ------GEHAM 1106
            ||:|:|..:.|...:.|:.|....|:::.|.|:||..|.|        :.|:.|      |:
  Rat   947 DNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGR--------VQYTFQNGEDGDGD--- 1000

  Fly  1107 LFDINNTTGEIIVASGQTIDRERTPRIQLQIKAEDSPGRPTDAKQSVVELQIEVLDVNDNAPEFT 1171
             |.|..|:|  ||.:.:.:|||..|..:|...|.|   |.....::.|.:|:.|.|||||||.|.
  Rat  1001 -FTIEPTSG--IVRTVRRLDREAVPVYELTAYAVD---RGVPPLRTPVSIQVTVQDVNDNAPVFP 1059

  Fly  1172 QKKYSTVIPENAQIDSFVLQLEAVDADEGLGGEVRYELVNEGEANGLFKIDTKSGLISTRRNLTG 1236
            .:::...:.||:.:.|.|.|:.|||.|:|....:.|::| ||....||::|..||.::...:|..
  Rat  1060 AEEFEVRVKENSIVGSVVAQITAVDPDDGPNAHIMYQIV-EGNIPELFQMDIFSGELTALIDLDY 1123

  Fly  1237 KGRAHPYVLIVRAQDNGNQMPKQPTLSTDTDVRIYIGDVSANDGVPYFLSPRVGQMANVTENAVT 1301
            :.| ..||::|:|       ...|.:|..|   :::..|..||..|            |..|
  Rat  1124 EAR-QEYVIVVQA-------TSAPLVSRAT---VHVRLVDQNDNSP------------VLNN--- 1162

  Fly  1302 GAPVFQVI----ASDPDDESTPSGTITYRILPDTPDA--------------EAFVIDAHSGLITT 1348
                ||::    .|:..| :.|||.|. ||....||.              :..|::..||.:..
  Rat  1163 ----FQILFNNYVSNRSD-TFPSGIIG-RIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGELRL 1221

  Fly  1349 RQSMDRETKDMYRILLEVSDNGQPKQSATRILQIAILDVD------------DHEPRFAR----- 1396
            .:.:|.....:..:|:.|:| |....:|..:|::.|:..:            ..:.||..
  Rat  1222 SRKLDNNRPLVASMLVTVTD-GLHSVTAQCVLRVVIITEELLANSLTVRLENMWQERFLSPLLGH 1285

  Fly  1397 --EADAGPLSMSV---------REEEPAGTIVG-NFSAL-DEDLGENAAIDYVIIDGNNEQLFTI 1448
              |..|..|:...         .:.:..||::. :|||| ....|..||..:...:...|||: :
  Rat  1286 FLEGVAAVLATPTEDVFIFNIQNDTDVGGTVLNVSFSALAPRGAGAGAAGPWFSSEELQEQLY-V 1349

  Fly  1449 ERNNESLAILKTKKPID-----REQVESFTLTIKCLKLGEPGYKFIGDPYDRQDLSHLRINVRVL 1508
            .|...:...|....|.|     ||..|::   :||                          |.||
  Rat  1350 RRAALAARSLLDVLPFDDNVCLREPCENY---MKC--------------------------VSVL 1385

  Fly  1509 DIDDNLP-------KFEQPDPTVGIRINVP 1531
            ..|.:.|       .|....|..|:|...|
  Rat  1386 RFDSSAPFLASASTLFRPIQPIAGLRCRCP 1415

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.