DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad74A and Celsr2

DIOPT Version :9

Sequence 1:NP_001246814.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:NP_001178039.1 Gene:Celsr2 / 83465 RGDID:69237 Length:2919 Species:Rattus norvegicus


Alignment Length:1492 Identity:356/1492 - (23%)
Similarity:602/1492 - (40%) Gaps:386/1492 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   126 PTFLGRPYTASVSESLPVGSELSVEPPIVVVDRDEGINSEVQMKCLEENDICDIFEVRAVKISDG 190
            |:..|.|::..:   |.:|..||.:..:.:......:.:. :::|    ..|.:.:...::..:|
  Rat   105 PSSEGCPWSCRL---LGIGGHLSPQGTLTLPQEHPCLKAP-RLRC----QSCKLAQAPGLRAGEG 161

  Fly   191 NYTARVALKQQLDFESRPSYILTISASDSALDNRLSSLATISINVIDIQDQPPIFTNAPYSATVP 255
            :....:..:::.:..:.|.:                              |||     .|.||||
  Rat   162 SREESMGGRRKRNVNTAPQF------------------------------QPP-----SYQATVP 191

  Fly   256 ENTPAGVSILTVKAVDGDVGIPREIFLSLE---DEPFGHFELVPFGDPRDGTAVLQTTSEPLDRE 317
            ||.|||.|:.:::|:|.|.|....:..:::   |....||..:   ||..|..   ||:|.||||
  Rat   192 ENQPAGTSVASLRAIDPDEGEAGRLEYTMDALFDSRSNHFFSL---DPITGAV---TTAEELDRE 250

  Fly   318 NAEILQNGGVYVFSIRATELIDGAIPAEHSLTRVTIVVTDVDDHQPTFSGPHFNVSITENLANGM 382
            ..      ..:||.:.|.   |..:|...:|..:||:|||.:||.|.|....:..|:.|||..| 
  Rat   251 TK------STHVFRVTAQ---DHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVG- 305

  Fly   383 PLPGLSIFVDDRDMGENSRYELSLRDVFNAARVFEVSPTESQGRTPVVVKVLNASRLDYDVVDPD 447
                                                                      |:|:.  
  Rat   306 ----------------------------------------------------------YEVLT-- 310

  Fly   448 LRKFEFDLVASVKGVEKAKTRVEIHLLDANDNAPVFDQGTYRFTAAENLPVDAIIGHVKATDLDS 512
                                                                     |:|||.|:
  Rat   311 ---------------------------------------------------------VRATDGDA 318

  Fly   513 GEFGHVRY-VLKGFG---ADNFYVNPETGGVYLLKPLDYEKQSSYSLTVVAIDGGQ----REANA 569
            ....::.| :|:|.|   ::.|.::|.:|.:....|:|.|:..||.|.|.|.|.|:    |.:.|
  Rat   319 PPNANILYRLLEGPGGSPSEVFEIDPRSGVIRTRGPVDREEVESYKLIVEASDQGRDPGPRSSTA 383

  Fly   570 NLFVGVTDVNDNHPNFESKEYSRTIREGAALFEPQFFVRAHDADGPSQGNGRVKYSIVSENSIAG 634
            .:|:.|.|.|||.|.|..|.|...:||......|...|.|.|.|..|  |..|.|||:|.|  |.
  Rat   384 VVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGS--NALVHYSIMSGN--AR 444

  Fly   635 NVFRIEPDTGEIVIQKAARSMDTE-RGEYELVVSATDFGIPPLSNTTRVLVRVGISGNQRPIFRG 698
            ..|.::..||.:.:   ...:|.| ..||.|.:.|.|.|.|||||.:.::....:..|       
  Rat   445 GQFYLDAQTGALDV---VSPLDYETTKEYTLRIRAQDGGRPPLSNVSGLVTVQVLDIN------- 499

  Fly   699 HFQNMENLPIIGPPSYRVSIPENAAAGSNVTSVSAHDPD-GLDSLLRYRIVGANDNFEIDEISGL 762
                 :|.||.....::.::.|:...|..|..|.|.|.| |.::.|.|.:.|...:|.....:|.
  Rat   500 -----DNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGENARLEYSLAGVGHDFPFTINNGT 559

  Fly   763 ITVSPQARIDRDSNMNSFEIIVNAVDSGTPIPETATTTVYVNVKDINDERPKFEQNSYATYVSER 827
            ..:|..|.:||: .::.:...|.|.|.||| ..||:.:|.|.:.|:||..|.|.|..|...::|.
  Rat   560 GWISVAAELDRE-EVDFYSFGVEARDHGTP-ALTASASVSVTILDVNDNNPTFTQPEYTVRLNED 622

  Fly   828 TAVGESVLRVKAIDKDLNSKLEYSMV-----GPVAATTKAG---VSIANRSNYRLQEAFRVDSQS 884
            .|||.||:.|.|:|:|.:|.:.|.:.     ...:.|:::|   ||:|...:|:|:..:.:...:
  Rat   623 AAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTA 687

  Fly   885 GEIFVNGTLRHDVAAIIIFTVGVRDLNAEVDPEGQVDTTEVTVYVQSFQDTNPVFKNTGWTSSRP 949
            .:    || |.|.|.|:   |.|.|.|..                      .|||:::.:|    
  Rat   688 SD----GT-RQDTAQIV---VNVTDANTH----------------------RPVFQSSHYT---- 718

  Fly   950 VIDVKIKEEMPIDSALFILQAEDPVTRQ--PITSFELIEPKQVDYFQVAERTGEVILKKRLDYEA 1012
               |.:.|:.|..:.:.::.|.|..|.:  .||.|   ....:..|::...||.|..:..|||| 
  Rat   719 ---VNVNEDRPAGTTVVLISATDEDTGENARITYF---MEDSIPQFRIDADTGAVTTQAELDYE- 776

  Fly  1013 LGDTGPEFELQVRA-NSADRQRSTVSRVNITVENVNDNSPRFERNSYQATIIENRPHPERVIRVR 1076
               ....:.|.:.| ::...|:|..:.:.|.|.:||||:|:|.|:|||.::.|:.|....|:::.
  Rat   777 ---DQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQIS 838

  Fly  1077 ALDKDAVLNARDERLGYHKIIYSLQG--EHAMLFDINNTTGEIIVASGQTIDRERTPRIQLQIKA 1139
            |.|:|:.||.|        :.|:.||  :....|.:.:|:|  ||.:.:.:|||...:..|:..|
  Rat   839 ATDRDSGLNGR--------VFYTFQGGDDGDGDFIVESTSG--IVRTLRRLDRENVAQYILRAYA 893

  Fly  1140 EDSPGRPTDAKQSVVELQIEVLDVNDNAPEFTQKKYSTVIPENAQIDSFVLQLEAVDADEGLGGE 1204
            .|. |.|  ..::.:|:.:.|||||||.|.|.|.::...:.||:.|...|.::.|.|.|||...:
  Rat   894 VDK-GMP--PARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQ 955

  Fly  1205 VRYELVNEGEANGLFKIDTKSGLISTRRNLTGKGRAHPYVLIVRAQDNGNQMPKQPTLSTDTDVR 1269
            :.|::| ||....:|::|..||.::...:|..:.|.. |:|:::|       ...|.:|..|   
  Rat   956 IMYQIV-EGNIPEVFQLDIFSGELTALVDLDYEDRPE-YILVIQA-------TSAPLVSRAT--- 1008

  Fly  1270 IYIGDVSANDGVPYFLSPRVGQMANVTENAVT-------GAPVFQVIASDPDDESTPSGTITYRI 1327
            :::..:..||..|.     :|....:..|.||       |..:.:|.|.|||    .|.::||..
  Rat  1009 VHVRLLDRNDNPPV-----LGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD----ISDSLTYSF 1064

  Fly  1328 LPDTPDAEAFVIDAHSGLITTRQSMDRETKDMYRILLEVSDNGQPKQSATRILQIAI-------- 1384
            .... :....:::|.:|.:...:::| ..:.:..|:..:..:|....:|...|::.|        
  Rat  1065 ERGN-ELSLVLLNASTGELRLSRALD-NNRPLEAIMSVLVSDGVHSVTAQCSLRVTIITDEMLTH 1127

  Fly  1385 ---LDVDDHEPRFAREADAGPLSMSVREEEPAGTIVGNFSALDEDLGENAAIDYVIIDGNNEQLF 1446
               |.::|..|    |....|| :.:..:..|.|:.             ...|:|::       |
  Rat  1128 SITLRLEDMSP----ERFLSPL-LGLFIQAVAATLA-------------TPPDHVVV-------F 1167

  Fly  1447 TIERNNESLAILKTKKPIDREQVESFTLTIKCLKLGEPGYKFIGDPY----DRQDLSHLRINV-- 1505
            .::|              |.:......|.:. |.:|:|.....|.|:    |.|:..:|..::  
  Rat  1168 NVQR--------------DTDAPGGHILNVS-LSVGQPPGPGGGPPFLPSEDLQERLYLNRSLLT 1217

  Fly  1506 -----RVLDIDDNLPKFEQPDPTVGIRINVPIDTVVTTLKASDADAEAPPVGLSIENVTFVP 1562
                 |||..|||            |.:..|.:..:..:.....|:.||.:..|  :|.|.|
  Rat  1218 AISAQRVLPFDDN------------ICLREPCENYMRCVSVLRFDSSAPFIASS--SVLFRP 1265

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_001246814.1 Cadherin_repeat 33..124 CDD:206637
Cadherin_repeat 132..240 CDD:206637 9/107 (8%)
Cadherin_repeat 249..361 CDD:206637 39/114 (34%)
Cadherin_repeat 369..479 CDD:206637 7/109 (6%)
Cadherin_repeat 487..581 CDD:206637 28/101 (28%)
Cadherin_repeat 589..686 CDD:206637 33/97 (34%)
Cadherin_repeat 713..810 CDD:206637 28/97 (29%)
Cadherin_repeat 819..936 CDD:206637 30/124 (24%)
Cadherin_repeat 953..1049 CDD:206637 25/98 (26%)
Cadherin_repeat 1057..1166 CDD:206637 34/110 (31%)
Cadherin_repeat 1175..1279 CDD:206637 25/103 (24%)
Cadherin_repeat 1293..1390 CDD:206637 21/114 (18%)
Cadherin_repeat 1402..1513 CDD:206637 22/121 (18%)
Cadherin_repeat 1523..1628 CDD:206637 9/40 (23%)
Celsr2NP_001178039.1 Cadherin_repeat 185..285 CDD:206637 39/114 (34%)
Cadherin_repeat 293..395 CDD:206637 35/219 (16%)
Cadherin_repeat 404..501 CDD:206637 34/115 (30%)
Cadherin_repeat 509..606 CDD:206637 29/98 (30%)
Cadherin_repeat 614..708 CDD:206637 30/101 (30%)
Cadherin_repeat 716..811 CDD:206637 26/108 (24%)
Cadherin_repeat 819..917 CDD:206637 34/110 (31%)
Cadherin_repeat 925..1019 CDD:206637 26/105 (25%)
Cadherin_repeat 1042..1120 CDD:206637 16/83 (19%)
EGF_CA 1289..1324 CDD:238011
EGF_CA 1333..1366 CDD:238011
LamG 1369..1552 CDD:238058
EGF_CA 1578..1609 CDD:238011
LamG 1618..1767 CDD:238058
EGF_CA 1795..1829 CDD:238011
Keratin_B2 1806..1956 CDD:279797
DSL <1819..1866 CDD:302925
EGF_Lam 1924..1969 CDD:214543
HormR 1972..2034 CDD:214468
GAIN 2052..2287 CDD:293098
GPS 2315..2368 CDD:197639
7tm_4 2374..2605 CDD:304433
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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