DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad74A and Celsr2

DIOPT Version :10

Sequence 1:NP_648973.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:NP_001178039.1 Gene:Celsr2 / 83465 RGDID:69237 Length:2919 Species:Rattus norvegicus


Alignment Length:1492 Identity:356/1492 - (23%)
Similarity:602/1492 - (40%) Gaps:386/1492 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   126 PTFLGRPYTASVSESLPVGSELSVEPPIVVVDRDEGINSEVQMKCLEENDICDIFEVRAVKISDG 190
            |:..|.|::..:   |.:|..||.:..:.:......:.:. :::|    ..|.:.:...::..:|
  Rat   105 PSSEGCPWSCRL---LGIGGHLSPQGTLTLPQEHPCLKAP-RLRC----QSCKLAQAPGLRAGEG 161

  Fly   191 NYTARVALKQQLDFESRPSYILTISASDSALDNRLSSLATISINVIDIQDQPPIFTNAPYSATVP 255
            :....:..:::.:..:.|.:                              |||     .|.||||
  Rat   162 SREESMGGRRKRNVNTAPQF------------------------------QPP-----SYQATVP 191

  Fly   256 ENTPAGVSILTVKAVDGDVGIPREIFLSLE---DEPFGHFELVPFGDPRDGTAVLQTTSEPLDRE 317
            ||.|||.|:.:::|:|.|.|....:..:::   |....||..:   ||..|..   ||:|.||||
  Rat   192 ENQPAGTSVASLRAIDPDEGEAGRLEYTMDALFDSRSNHFFSL---DPITGAV---TTAEELDRE 250

  Fly   318 NAEILQNGGVYVFSIRATELIDGAIPAEHSLTRVTIVVTDVDDHQPTFSGPHFNVSITENLANGM 382
            ..      ..:||.:.|.   |..:|...:|..:||:|||.:||.|.|....:..|:.|||..| 
  Rat   251 TK------STHVFRVTAQ---DHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVG- 305

  Fly   383 PLPGLSIFVDDRDMGENSRYELSLRDVFNAARVFEVSPTESQGRTPVVVKVLNASRLDYDVVDPD 447
                                                                      |:|:.  
  Rat   306 ----------------------------------------------------------YEVLT-- 310

  Fly   448 LRKFEFDLVASVKGVEKAKTRVEIHLLDANDNAPVFDQGTYRFTAAENLPVDAIIGHVKATDLDS 512
                                                                     |:|||.|:
  Rat   311 ---------------------------------------------------------VRATDGDA 318

  Fly   513 GEFGHVRY-VLKGFG---ADNFYVNPETGGVYLLKPLDYEKQSSYSLTVVAIDGGQ----REANA 569
            ....::.| :|:|.|   ::.|.::|.:|.:....|:|.|:..||.|.|.|.|.|:    |.:.|
  Rat   319 PPNANILYRLLEGPGGSPSEVFEIDPRSGVIRTRGPVDREEVESYKLIVEASDQGRDPGPRSSTA 383

  Fly   570 NLFVGVTDVNDNHPNFESKEYSRTIREGAALFEPQFFVRAHDADGPSQGNGRVKYSIVSENSIAG 634
            .:|:.|.|.|||.|.|..|.|...:||......|...|.|.|.|..|  |..|.|||:|.|  |.
  Rat   384 VVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGS--NALVHYSIMSGN--AR 444

  Fly   635 NVFRIEPDTGEIVIQKAARSMDTE-RGEYELVVSATDFGIPPLSNTTRVLVRVGISGNQRPIFRG 698
            ..|.::..||.:.:   ...:|.| ..||.|.:.|.|.|.|||||.:.::....:..|       
  Rat   445 GQFYLDAQTGALDV---VSPLDYETTKEYTLRIRAQDGGRPPLSNVSGLVTVQVLDIN------- 499

  Fly   699 HFQNMENLPIIGPPSYRVSIPENAAAGSNVTSVSAHDPD-GLDSLLRYRIVGANDNFEIDEISGL 762
                 :|.||.....::.::.|:...|..|..|.|.|.| |.::.|.|.:.|...:|.....:|.
  Rat   500 -----DNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGENARLEYSLAGVGHDFPFTINNGT 559

  Fly   763 ITVSPQARIDRDSNMNSFEIIVNAVDSGTPIPETATTTVYVNVKDINDERPKFEQNSYATYVSER 827
            ..:|..|.:||: .::.:...|.|.|.||| ..||:.:|.|.:.|:||..|.|.|..|...::|.
  Rat   560 GWISVAAELDRE-EVDFYSFGVEARDHGTP-ALTASASVSVTILDVNDNNPTFTQPEYTVRLNED 622

  Fly   828 TAVGESVLRVKAIDKDLNSKLEYSMV-----GPVAATTKAG---VSIANRSNYRLQEAFRVDSQS 884
            .|||.||:.|.|:|:|.:|.:.|.:.     ...:.|:::|   ||:|...:|:|:..:.:...:
  Rat   623 AAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTA 687

  Fly   885 GEIFVNGTLRHDVAAIIIFTVGVRDLNAEVDPEGQVDTTEVTVYVQSFQDTNPVFKNTGWTSSRP 949
            .:    || |.|.|.|:   |.|.|.|..                      .|||:::.:|    
  Rat   688 SD----GT-RQDTAQIV---VNVTDANTH----------------------RPVFQSSHYT---- 718

  Fly   950 VIDVKIKEEMPIDSALFILQAEDPVTRQ--PITSFELIEPKQVDYFQVAERTGEVILKKRLDYEA 1012
               |.:.|:.|..:.:.::.|.|..|.:  .||.|   ....:..|::...||.|..:..|||| 
  Rat   719 ---VNVNEDRPAGTTVVLISATDEDTGENARITYF---MEDSIPQFRIDADTGAVTTQAELDYE- 776

  Fly  1013 LGDTGPEFELQVRA-NSADRQRSTVSRVNITVENVNDNSPRFERNSYQATIIENRPHPERVIRVR 1076
               ....:.|.:.| ::...|:|..:.:.|.|.:||||:|:|.|:|||.::.|:.|....|:::.
  Rat   777 ---DQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQIS 838

  Fly  1077 ALDKDAVLNARDERLGYHKIIYSLQG--EHAMLFDINNTTGEIIVASGQTIDRERTPRIQLQIKA 1139
            |.|:|:.||.|        :.|:.||  :....|.:.:|:|  ||.:.:.:|||...:..|:..|
  Rat   839 ATDRDSGLNGR--------VFYTFQGGDDGDGDFIVESTSG--IVRTLRRLDRENVAQYILRAYA 893

  Fly  1140 EDSPGRPTDAKQSVVELQIEVLDVNDNAPEFTQKKYSTVIPENAQIDSFVLQLEAVDADEGLGGE 1204
            .|. |.|  ..::.:|:.:.|||||||.|.|.|.::...:.||:.|...|.::.|.|.|||...:
  Rat   894 VDK-GMP--PARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQ 955

  Fly  1205 VRYELVNEGEANGLFKIDTKSGLISTRRNLTGKGRAHPYVLIVRAQDNGNQMPKQPTLSTDTDVR 1269
            :.|::| ||....:|::|..||.::...:|..:.|.. |:|:::|       ...|.:|..|   
  Rat   956 IMYQIV-EGNIPEVFQLDIFSGELTALVDLDYEDRPE-YILVIQA-------TSAPLVSRAT--- 1008

  Fly  1270 IYIGDVSANDGVPYFLSPRVGQMANVTENAVT-------GAPVFQVIASDPDDESTPSGTITYRI 1327
            :::..:..||..|.     :|....:..|.||       |..:.:|.|.|||    .|.::||..
  Rat  1009 VHVRLLDRNDNPPV-----LGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD----ISDSLTYSF 1064

  Fly  1328 LPDTPDAEAFVIDAHSGLITTRQSMDRETKDMYRILLEVSDNGQPKQSATRILQIAI-------- 1384
            .... :....:::|.:|.:...:::| ..:.:..|:..:..:|....:|...|::.|        
  Rat  1065 ERGN-ELSLVLLNASTGELRLSRALD-NNRPLEAIMSVLVSDGVHSVTAQCSLRVTIITDEMLTH 1127

  Fly  1385 ---LDVDDHEPRFAREADAGPLSMSVREEEPAGTIVGNFSALDEDLGENAAIDYVIIDGNNEQLF 1446
               |.::|..|    |....|| :.:..:..|.|:.             ...|:|::       |
  Rat  1128 SITLRLEDMSP----ERFLSPL-LGLFIQAVAATLA-------------TPPDHVVV-------F 1167

  Fly  1447 TIERNNESLAILKTKKPIDREQVESFTLTIKCLKLGEPGYKFIGDPY----DRQDLSHLRINV-- 1505
            .::|              |.:......|.:. |.:|:|.....|.|:    |.|:..:|..::  
  Rat  1168 NVQR--------------DTDAPGGHILNVS-LSVGQPPGPGGGPPFLPSEDLQERLYLNRSLLT 1217

  Fly  1506 -----RVLDIDDNLPKFEQPDPTVGIRINVPIDTVVTTLKASDADAEAPPVGLSIENVTFVP 1562
                 |||..|||            |.:..|.:..:..:.....|:.||.:..|  :|.|.|
  Rat  1218 AISAQRVLPFDDN------------ICLREPCENYMRCVSVLRFDSSAPFIASS--SVLFRP 1265

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_648973.1 Cadherin_repeat 33..124 CDD:206637
Cadherin_repeat 132..240 CDD:206637 9/107 (8%)
Cadherin_repeat 249..361 CDD:206637 39/114 (34%)
Cadherin_repeat 487..581 CDD:206637 28/101 (28%)
Cadherin_repeat 589..686 CDD:206637 33/97 (34%)
Cadherin_repeat 713..810 CDD:206637 28/97 (29%)
Cadherin_repeat 819..936 CDD:206637 30/124 (24%)
Cadherin_repeat 953..1049 CDD:206637 25/98 (26%)
Cadherin_repeat 1057..1166 CDD:206637 34/110 (31%)
Cadherin_repeat 1175..1279 CDD:206637 25/103 (24%)
Cadherin_repeat 1293..1390 CDD:206637 21/114 (18%)
Cadherin_repeat 1402..1513 CDD:206637 22/121 (18%)
Cadherin_repeat 1523..1628 CDD:206637 9/40 (23%)
Celsr2NP_001178039.1 Cadherin_repeat 185..285 CDD:206637 39/114 (34%)
Cadherin_repeat 293..395 CDD:206637 35/219 (16%)
Cadherin_repeat 404..501 CDD:206637 34/115 (30%)
Cadherin_repeat 509..606 CDD:206637 29/98 (30%)
Cadherin_repeat 614..708 CDD:206637 30/101 (30%)
Cadherin_repeat 716..811 CDD:206637 26/108 (24%)
Cadherin_repeat 819..917 CDD:206637 34/110 (31%)
Cadherin_repeat 925..1019 CDD:206637 26/105 (25%)
Cadherin_repeat 1042..1120 CDD:206637 16/83 (19%)
EGF_CA 1289..1324 CDD:238011
EGF_CA 1333..1366 CDD:238011
LamG 1369..1552 CDD:238058
EGF_CA 1578..1609 CDD:238011
Laminin_G_2 1644..1770 CDD:460494
EGF_CA 1795..1829 CDD:238011
DSL 1819..1868 CDD:473190
EGF_Lam 1924..1969 CDD:214543
HormR 1972..2034 CDD:214468
GAIN 2051..2289 CDD:465137
GPS 2315..2368 CDD:197639
7tmB2_CELSR2 2373..2626 CDD:320658
TM helix 1 2375..2400 CDD:320658
TM helix 2 2409..2431 CDD:320658
TM helix 3 2440..2467 CDD:320658
TM helix 4 2479..2499 CDD:320658
TM helix 5 2516..2545 CDD:320658
TM helix 6 2557..2584 CDD:320658
TM helix 7 2588..2613 CDD:320658
Blue background indicates that the domain is not in the aligned region.

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