DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cad74A and Fat2

DIOPT Version :9

Sequence 1:NP_001246814.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:NP_075243.1 Gene:Fat2 / 65048 RGDID:620656 Length:4351 Species:Rattus norvegicus


Alignment Length:1802 Identity:458/1802 - (25%)
Similarity:762/1802 - (42%) Gaps:338/1802 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 LSLTAGQLVNQPPQFVPGTGDMSRFSLSENTPVGSPV----------------FQLKGTDPEGGR 58
            :|||  |::::..||   ..|:.|..::||||....:                |.|.|||     
  Rat  1956 ISLT--QVLDKSLQF---DQDVYRARVTENTPHRKALVILGVHGNHLNDTLSYFLLNGTD----- 2010

  Fly    59 LKYSISGPVFSVDRETGVVRLR-QELDRETQDTVEVIISITDEGIYGTEPNTVSQRRV-IPVRDY 121
                    :|.:....||::.| ...|||.|||.||.:.:.|..:    |..|:|..| :.|.|.
  Rat  2011 --------LFHMIESAGVLQTRGGTFDREQQDTHEVAVEVRDNRV----PQRVAQALVRVSVEDV 2063

  Fly   122 NDNQPTFLGRPYTASVSESL------------------------------------PVGSELSVE 150
            |||.|.|...||...:.:..                                    |...::|::
  Rat  2064 NDNIPEFQHLPYYTVIQDGTEPGDVLFQVSATDKDLGANGSVTYGFAEDYAYFRIDPYVGDISLK 2128

  Fly   151 PP----------IVVVDRDEGI---NSEVQMKCLEENDICDIFE--VRAVKISDG--NYT----- 193
            .|          :.|:.||.||   .:||::.....|....:|:  ...||:.:.  .||     
  Rat  2129 KPFDYQALNKYHLRVIARDSGIPPLQTEVEVHVTVRNKSNPLFQSPYYKVKVPENITLYTPILHT 2193

  Fly   194 -AR----------------------------VALKQQLDFESRPSYILTISASDSALDNRLSSLA 229
             ||                            :.:...||:||:..::.|:.|:|:||.:  .|.|
  Rat  2194 QARSPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKNKHVFTVRATDTALGS--FSEA 2256

  Fly   230 TISINVIDIQDQPPIFTNAPYSATVPENTPAGVSILTVKAVDGDVGIPREIFLSLEDEPFGHFEL 294
            |:.:.|.||.|.||.|:...|:.:|.|.:||...::.:.|.|.|.|..:::          .:::
  Rat  2257 TVEVLVEDINDNPPTFSQLVYTTSVSEGSPAQTPVIQLLASDQDSGQNQDV----------SYQI 2311

  Fly   295 VPFGDPRDGTAVLQ-----------TTSEPLDRENAEILQNGGVYVFSIRATELIDGAIPAEHSL 348
            |     .||:.|.:           .|.:.||.|..:..:      ..:||.:..|..:..|   
  Rat  2312 V-----EDGSDVSKFFRINGSTGEIFTIQELDYETHQHFR------VKVRAMDKGDPPLTGE--- 2362

  Fly   349 TRVTIVVTDVDDHQPTFSGPHFNVSITENLANGMPLPGLSIFVDDRDMGENSRYELSLRDVFNAA 413
            |.|.:.|:|::|:.|.|..|.:..:::|....|..:  |.:...|.|:|:.||.|..:.. .|..
  Rat  2363 TLVVVNVSDINDNPPKFREPQYEANVSELATCGHLV--LKVQALDPDIGDTSRLEYLILS-GNQD 2424

  Fly   414 RVFEVSPTESQGRTPVVVKVLNASRLDYDVVDPDLRKFEFDL-VASVKGVEKAKTRVEIHLLDAN 477
            |.|.::.|..      ::.:.|..:...|        ..::| |.:..||.:|...|.|:..:||
  Rat  2425 RHFSINSTSG------IISMFNLCKKQLD--------SSYNLRVGASDGVFRATVPVYINTTNAN 2475

  Fly   478 DNAPVFDQGTYRFTAAENLPVDAIIGHVKATDLDSGEFGHVRY-VLKGFGADNFYVNPETGGVYL 541
            ..:|.|.|..|....|||..|...:..:.|.|.|||.:|.|.| ::.....:.|::||. |.:..
  Rat  2476 KYSPEFQQNVYEAELAENAKVGTKVIELLAIDKDSGPYGTVDYTIINKLAGERFFINPR-GQITT 2539

  Fly   542 LKPLDYEKQSS--YSLTVVAIDGGQREANANLFVGVTDVNDNHPNFESKEYSRTIREGAALFEPQ 604
            |:.||.|..:.  .::.|:|.|||.:.|...:.:.:||.|||.|.|::..|:.:|....:...|.
  Rat  2540 LQKLDRENSTERVIAIKVMARDGGGKVAFCTVKIILTDENDNAPQFKASGYTVSIPSNVSRDSPI 2604

  Fly   605 FFVRAHDADGPSQG-NGRVKYSIVSENSIAGNVFRIEPDTGEIVIQKAARSMDTERGEYELVVSA 668
            ..|.|:|||   :| |..|.||:.|...:|..:..:.|.||.:.::::...::....::.  :.|
  Rat  2605 IQVLAYDAD---EGRNADVTYSVDSTEDLAEEIIEVNPTTGVVKVKESLVGLENRAVDFN--IKA 2664

  Fly   669 TDFGIPPLSNTTRVLVRVGISGNQRPIFRGHFQNMENLPIIGPPSYRVSIPENAAAGS---NVTS 730
            .|.|.|...:.  |.||:.:..|:.|           ||....|.|..|.||:...||   :|.:
  Rat  2665 QDGGPPHWDSL--VPVRLQVVPNEIP-----------LPKFSEPLYTFSAPEDLPEGSEIGSVKA 2716

  Fly   731 VSAHDPDGLDSLLRYRIV-------GANDNFEIDEISGLITVSPQARIDRDS-NMNSFEIIVNAV 787
            |:|.||      :.|.:|       .::|.|.:|:.:|::.|  :..:|.:| .....:::.:..
  Rat  2717 VAAQDP------IIYSLVQGTTPESNSDDVFSLDQDTGVLKV--RKAMDHESTKWYQIDLMAHCP 2773

  Fly   788 DSGTPIPETATTTVYVNVKDINDERPKFEQNSYATYVSERTAVGESVLRVKAIDKDLNS--KLEY 850
            ...|.:  .:..:|.:.|:|:||.||.||.:.|..:::|....|.:|::|.|.|:|..|  ::.|
  Rat  2774 HEDTDL--VSLVSVSIQVEDVNDNRPVFEADPYKAFLTENMPGGTTVIQVTANDQDTGSDGQVSY 2836

  Fly   851 SMVGPVAATTKAGVSIANRSNYRLQEAFRVDSQSGEIFVNGTLRHDVAAIIIFTVGVRDLNAEVD 915
            .:            |:...||  :.|.|.|||:||.|.....|..:......|.|...|....:.
  Rat  2837 RL------------SVEPGSN--IHELFAVDSESGWITTLQELDCETQQTYRFYVVAFDHGQTIQ 2887

  Fly   916 PEGQVDTTEVTVYVQSFQDTNPVFKNTGWTSSRPVIDVKIKEEMPIDSALFILQAEDPVTRQPIT 980
            ...|   ..|.|.:....|..|.|.:..:..|    .|:..|...:.:.|..|.|:.....:.:|
  Rat  2888 LSSQ---ALVEVSITDENDNPPRFASEDYRGS----VVENNEPGELVATLKTLDADVSDQNRQVT 2945

  Fly   981 SFELIEPKQVDYFQVAERTGE--VILKKRLDYEALGDTGPEFELQVRANSADRQRSTVSRVNITV 1043
            .: :.|...:..|.:::...|  :..:|.||.|.:.    ::.|:|.|:....|.|.  .|.:.|
  Rat  2946 CY-ITEGDPLGQFSISQVGDEWRISSRKTLDREHIA----KYLLRVTASDGKFQASV--PVEVFV 3003

  Fly  1044 ENVNDNSPRFERNSYQATIIENRPHPERVIRVRALDKDAVLNARDERLGYHKIIYSLQGEHAMLF 1108
            .::|||||:..:..|...:.|:......:::|.|:|.|...||        :|.|||.|..|..|
  Rat  3004 VDINDNSPQCSQLLYTGKVREDVTPGHFILKVSAIDVDMDTNA--------QITYSLHGPGAQEF 3060

  Fly  1109 DINNTTGEIIVASGQTIDRERTPRIQLQIKAEDSPGRPTDAKQSVVELQIEVLDVNDNAPEFTQK 1173
            .::..|||:...:  .:||||.....|..||.|..|:...|:   |.|.||  |||||||.|...
  Rat  3061 KLDPHTGELTTLT--VLDRERKDVYNLVAKATDGGGQSCQAE---VTLHIE--DVNDNAPRFFPS 3118

  Fly  1174 KYSTVIPENAQIDSFVLQLEAVDADEGLGGEVRYELVNEGEANGLFKIDTKSGLISTRRNLTGKG 1238
            .....:.:|..:.:.|..:.|.|.|:|...:|.|.|.:  .|:|.|.||..||:|...:.|  :.
  Rat  3119 HCDVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLTD--SADGQFSIDATSGVIRLEKPL--QV 3179

  Fly  1239 RAHPYV-LIVRAQDNGNQMPKQPTLSTDTDVRIYIGDVSANDGVPYFLSPRVGQMANVTENAVTG 1302
            ||...| |.|||.|.|..:|.. ||.|.|     :..|...|.:|.||:..  ....|.|:|...
  Rat  3180 RASSAVELTVRASDLGTPIPLS-TLGTVT-----VSVVGLEDYLPIFLNAE--HSTQVPEDAPID 3236

  Fly  1303 APVFQVIA-SDPDDESTPSGTITYRILPDTPDAEAFVIDAHSGLITTRQSMDRETKDMYRILLEV 1366
            ..|..:.. :.|..|.|     .|.|.......: |.:|||:|::....|:|.||...|.:.:|.
  Rat  3237 MEVLHLATLTRPGSEKT-----GYHITGGNEQGK-FRLDAHTGILYVNGSLDFETNPKYFLSIEC 3295

  Fly  1367 SDNGQPKQSATRILQIAILDVDDHEPRFAREADAGPLSMSVREEEPAGTIVGNFSALDEDLGENA 1431
            |.......|....:.|.:.||::|.|||..:.    .::.|.|....|.::...||.|:|...|:
  Rat  3296 SRKSSSSLSDVTTIVINVTDVNEHHPRFTHDL----YTVRVLENAVVGDVILTVSASDDDGPVNS 3356

  Fly  1432 AIDYVIIDGNNEQLFTIERNNESLAILKTKKPIDREQVESFTLTIKCLKLGEPGYKFIGDPYDRQ 1496
            ||.|.::.||....|||   |.....|:..|.:|.||..|::|.::....|:|..        .:
  Rat  3357 AITYSLVGGNQLGHFTI---NPKKGKLQVAKALDWEQTPSYSLRLRATDSGQPPL--------HE 3410

  Fly  1497 DLSHLRINVRVLDIDDNLPKFEQPDPTVGIRINVPIDTVVTTLKASDADAEAPPVGLSIENVTFV 1561
            |   ..:.|.|:|::||.|:|.|.:.:..::.|.||...|..|...|.|  :|..|        .
  Rat  3411 D---TEVAVEVVDVNDNPPRFFQLNYSTSVQENSPIGIKVLQLILDDPD--SPQNG--------P 3462

  Fly  1562 PQFYKRSRSLAVGNLHNLFTLNNRTGELRTGGSFADYVDGYFLMRVMANNSVQPKRQAHSNLKVF 1626
            |.|::    :..||..::|.: ...|.|.|..|.:.....::.:.:..::|..|...:.:.::|.
  Rat  3463 PYFFR----ITEGNTGSVFRV-TPDGWLVTAASLSKKAREWYQLHIEVSDSGLPPLSSSTLVRVQ 3522

  Fly  1627 VIRDKSLLKFVFARPPN--EIQHNIRPFQEQLQKKLKPLGLELHVLD 1671
            |......       ||:  .::.:|...:|:.|..:  :| ::|..|
  Rat  3523 VTEQSRY-------PPSTLPLEISITKGEEEFQGGM--IG-KIHATD 3559

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_001246814.1 Cadherin_repeat 33..124 CDD:206637 30/108 (28%)
Cadherin_repeat 132..240 CDD:206637 35/194 (18%)
Cadherin_repeat 249..361 CDD:206637 25/122 (20%)
Cadherin_repeat 369..479 CDD:206637 24/110 (22%)
Cadherin_repeat 487..581 CDD:206637 30/96 (31%)
Cadherin_repeat 589..686 CDD:206637 24/97 (25%)
Cadherin_repeat 713..810 CDD:206637 24/107 (22%)
Cadherin_repeat 819..936 CDD:206637 29/118 (25%)
Cadherin_repeat 953..1049 CDD:206637 21/97 (22%)
Cadherin_repeat 1057..1166 CDD:206637 35/108 (32%)
Cadherin_repeat 1175..1279 CDD:206637 33/104 (32%)
Cadherin_repeat 1293..1390 CDD:206637 25/97 (26%)
Cadherin_repeat 1402..1513 CDD:206637 30/110 (27%)
Cadherin_repeat 1523..1628 CDD:206637 21/104 (20%)
Fat2NP_075243.1 Cadherin_repeat 38..143 CDD:206637
Cadherin_repeat 152..249 CDD:206637
Cadherin_repeat 366..454 CDD:206637
Cadherin_repeat 462..560 CDD:206637
Cadherin_repeat 570..661 CDD:206637
Cadherin_repeat 719..816 CDD:206637
Cadherin_repeat 825..921 CDD:206637
Cadherin_repeat 931..1026 CDD:206637
Cadherin_repeat 1036..1133 CDD:206637
Cadherin_repeat 1141..1238 CDD:206637
Cadherin_repeat 1247..1335 CDD:206637
Cadherin_repeat 1354..1444 CDD:206637
Cadherin_repeat 1452..1551 CDD:206637
Cadherin_repeat 1560..1650 CDD:206637
Cadherin_repeat 1664..1754 CDD:206637
Cadherin_repeat 1766..1867 CDD:206637
E_set 1877..1959 CDD:298831 1/2 (50%)
Cadherin_repeat 1972..2066 CDD:206637 30/110 (27%)
Cadherin_repeat 2074..2163 CDD:206637 12/88 (14%)
Cadherin_repeat 2176..2268 CDD:206637 21/93 (23%)
Cadherin_repeat 2276..2375 CDD:206637 25/122 (20%)
Cadherin_repeat 2383..2475 CDD:206637 22/108 (20%)
Cadherin_repeat 2485..2581 CDD:206637 30/96 (31%)
Cadherin_repeat 2590..2683 CDD:206637 25/99 (25%)
Cadherin_repeat 2697..2795 CDD:206637 25/107 (23%)
Cadherin_repeat 2803..2904 CDD:206637 28/117 (24%)
Cadherin_repeat 2913..3009 CDD:206637 22/106 (21%)
Cadherin_repeat 3018..3111 CDD:206637 35/107 (33%)
Cadherin_repeat 3122..3211 CDD:206637 32/98 (33%)
Cadherin_repeat 3226..3319 CDD:206637 25/98 (26%)
Cadherin_repeat 3328..3424 CDD:206637 30/109 (28%)
Cadherin 3433..3524 CDD:278457 21/105 (20%)
Cadherin_repeat 3535..3621 CDD:206637 6/28 (21%)
Laminin_G_2 3802..3923 CDD:280389
EGF_CA 3953..3986 CDD:238011
EGF 3992..4022 CDD:278437
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4316..4340
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24026
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.100

Return to query results.
Submit another query.