DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cad74A and CDH23

DIOPT Version :10

Sequence 1:NP_648973.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:NP_071407.4 Gene:CDH23 / 64072 HGNCID:13733 Length:3354 Species:Homo sapiens


Alignment Length:1901 Identity:530/1901 - (27%)
Similarity:836/1901 - (43%) Gaps:350/1901 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 GQLVNQPPQFVPGTGDMSRFSLSENTPVGSPVFQLKGTDPEGGRLKYSISGP----VFSVDRETG 75
            || ||:.|.|.....| :...:||:|||||.|.||...|.:...|.:.:||.    .|:|:.:||
Human    23 GQ-VNRLPFFTNHFFD-TYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTG 85

  Fly    76 VVRLRQELDRETQDTVEVIISITD-EGIYGTEPNTVSQRRVIPVRDYNDNQPTFLGRPYTASVSE 139
            ||.|||.|||||:....|..|::| :|:       ::::..|.|.|.|||.|||..:||:..:.|
Human    86 VVWLRQPLDRETKSEFTVEFSVSDHQGV-------ITRKVNIQVGDVNDNAPTFHNQPYSVRIPE 143

  Fly   140 SLPVGSELSVEPPIVVV---DRDEGINSEVQMKCLEENDICDIFEVRAVKISDGNYTARVALKQQ 201
            :.|||:      ||.:|   |.|.|....|.......:....|...|.:          |.:.::
Human   144 NTPVGT------PIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGI----------VTVIRE 192

  Fly   202 LDFESRPSYILTISASDSALDNRLSSLATISINVIDIQDQPPIFTNAPYSATVPENTPAGVSILT 266
            ||:|:..:|.||::|:|......||:||.::|.:.|:||..|||.|.|||..:.|::|.|.::..
Human   193 LDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRI 257

  Fly   267 VKAVDGDVGIPREI-FLSLEDEPFGHFELVPFGDPRDGTAVLQTTSEPLDRENAEILQNGGVYVF 330
            :.|:|.|.|.||.| :..:.......|.|       |..:.:.|.:..|||||.  |.:.| ::.
Human   258 ITAIDQDKGRPRGIGYTIVSGNTNSIFAL-------DYISGVLTLNGLLDRENP--LYSHG-FIL 312

  Fly   331 SIRATELIDGAIPAEHSLTRV-TIVVTDVDDHQPTFSGPHFNVSITENLANGMPLPGLSIFVDDR 394
            :::.|||.|...|::.::|.. .|:|.|::|:.|.|:...::|:|||....|..|| |.|.|.|:
Human   313 TVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALP-LFIQVVDK 376

  Fly   395 D--MGENSRYELSLRDVFNAARVFEVSPTESQGRTPVVVKVLNASRLDYDVVDPDLRKFEFDLVA 457
            |  :|.||.:|:.|  |.|.:..|.:|||..||:..:.::|  |..|||:.||    :::|||.|
Human   377 DENLGLNSMFEVYL--VGNNSHHFIISPTSVQGKADIRIRV--AIPLDYETVD----RYDFDLFA 433

  Fly   458 SVKGVEK-AKTRVEIHLLDANDNAPVFDQGTYRFTAAENLPVDAIIGHVKATDLDSGEFGHVRYV 521
            :....:. ...:|:|.|::.|||.|:|.|..|..:..||:.|...:..|.|||.|:|.||.|.|.
Human   434 NESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYF 498

  Fly   522 LKGFGADNFYVNPETGGVYLLKPLDYEKQSSYSLTVVAIDGGQREANANLFVGVTDVNDNHPNFE 586
            ... ..|.|.::.:||.:.|:..||||....::||::|.|||..|....:.:.|.|||||.|.|:
Human   499 FSD-DPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQ 562

  Fly   587 SKEYSRTIREGAALFEPQFFVRAHDADGPSQGNGRVKYSIVSENSIAGNVFRIEPDTGEIVIQKA 651
            ...|...:||..........:||.|.|.|.  |.::.|||||.::. |:.|.|....|..|| ..
Human   563 KDAYVGALRENEPSVTQLVRLRATDEDSPP--NNQITYSIVSASAF-GSYFDISLYEGYGVI-SV 623

  Fly   652 ARSMDTER---GEYELVVSATDFGIPPLSNTTRVLVRVGISGNQRPIFRGHFQNMENLPIIGPPS 713
            :|.:|.|:   |...|.|.|.|.|.|||::|..|.:.|             |...:|.|....|:
Human   624 SRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV-------------FDENDNPPTFSKPA 675

  Fly   714 YRVSIPENAAAGSNVTSVSAHDPD-----GLDSLLRYRIVGANDNFEIDEISGLITVSPQARIDR 773
            |.||:.||..||:.|..::|.|.|     |.:|:: |.:.|:. .|.|:..||.||.:  :.:||
Human   676 YFVSVVENIMAGATVLFLNATDLDRSREYGQESII-YSLEGST-QFRINARSGEITTT--SLLDR 736

  Fly   774 DSNMNSFEIIVNAVDSGT-PIPETATTTVYVNVKDINDERPKFEQNSYATYVSERTAVGESVLRV 837
            ::. :.:.:||.|||.|. ...:|...||.:.:.||||..|.::...|...:.|.|.....|..|
Human   737 ETK-SEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTV 800

  Fly   838 KAIDKDL--NSKLEYSMVGPVAATTKAGVSIANRSNYRLQEAFRVDSQSGEIFVNGTL------- 893
            .|:|.||  |..|.||:..|                   .:.:.::|.:|:|.....:       
Human   801 VAVDPDLGENGTLVYSIQPP-------------------NKFYSLNSTTGKIRTTHAMLDRENPD 846

  Fly   894 RHDVAAIIIFTVGVRD-----LNAEVDPEGQVDTTEVTVYVQ--SFQDTNPVFKNTGWTSSRPVI 951
            .|:...:....|.|.|     |.|         |:..||:|.  ...|.:|.|:|..:.:     
Human   847 PHEAELMRKIVVSVTDCGRPPLKA---------TSSATVFVNLLDLNDNDPTFQNLPFVA----- 897

  Fly   952 DVKIKEEMPIDSALFILQAED-PVTRQPITSFEL-IEPKQVDYFQVAERTGEVILKKRLDYEALG 1014
              ::.|.:|...:::.:.|.| ......:.|:.: :...::| |.:...:|.|:....||.|.:.
Human   898 --EVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMD-FLINSSSGVVVTTTELDRERIA 959

  Fly  1015 DTGPEFELQVRANSADR-QRSTVSRVNITVENVNDNSPRFERNSYQATIIENRPHPERVIRVRAL 1078
                |::|:|.|:.|.. .:|:.|.:.|.|.:|||.:|.|....|..::.|:.|...||:.:...
Human   960 ----EYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCT 1020

  Fly  1079 DKDAVLNARDERLGYHKIIYSLQGEHAMLFDINNTTG-------EIIVASGQTIDRERTPRIQLQ 1136
            |.|..|||        ::.|.:.|        .|..|       :.:|.:...:|||.|....|.
Human  1021 DNDVGLNA--------ELSYFITG--------GNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLI 1069

  Fly  1137 IKAEDSPGRPTDAKQSVVELQIEVLDVNDNAPEFTQKKYSTVIPENAQIDSFVLQLEAVDADEGL 1201
            ::|.|: |...........:.:.|||||||.|.|.|..|...:||:......:|||:|.|||||.
Human  1070 LEAIDN-GPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGE 1133

  Fly  1202 GGEVRYELVNEGEANGLFKIDTKSGLISTRRNLTGKGRAHPYVLIVRA--QDNGNQMPKQPTLST 1264
            .|.|.|.:::....|. |:|...:||:........:.|...:||||.|  .|.|       .:.:
Human  1134 FGRVWYRILHGNHGNN-FRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG-------PMRS 1190

  Fly  1265 DTDVRIYIGDVSANDGVPYFLSPRVGQMANVTENAVTGAPVFQVIASDPD--------------- 1314
            ...|.:|:.|:  ||..|.|...:..:: .:.|.|..|..|..|.|:|.|               
Human  1191 SVRVIVYVEDI--NDEAPVFTQQQYSRL-GLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGA 1252

  Fly  1315 ------DEST------------------------------------------------------- 1318
                  ||||                                                       
Human  1253 EGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNAS 1317

  Fly  1319 ---------PSGT---------------ITYRI--LPDTPDAEAFVIDAHSGLITTRQSMDRETK 1357
                     ..||               ||||.  ...|.....|.|||.:|:||.:..:|||..
Human  1318 YEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKG 1382

  Fly  1358 DMYRILLEVSDNGQPKQSATRILQIAILDVDDHEPRFAREADAGPLSMSVREEEPAGTIVGNFSA 1422
            |.|.:.: |:|:|.||..:|..:.|.:||.:|:.|||...:|:   ::|:.|:.|.|..|....|
Human  1383 DFYTLTV-VADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDS---AVSIPEDCPVGQRVATVKA 1443

  Fly  1423 LDEDLGENAAIDYVIIDGNNEQLFTIERNNESLAILKTKKPIDREQVESFTLTIKCLKLGEPGYK 1487
            .|.|.|.|..:.:.:..||....|.|...|:|:..:...:|:|||:::.:.|.:.....|.|..|
Human  1444 WDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRK 1508

  Fly  1488 FIGDPYDRQDLSHLRINVRVLDIDDNLPKFEQP-DPTVGIRINVPIDTVVTTLKASDADAEAPPV 1551
                      ..|: :.|.:|||:||.|..|.| ...|.:..||...|.|..::|:|.|     :
Human  1509 ----------KDHI-LQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRD-----I 1557

  Fly  1552 GLSIENVTFVPQFYKRSRSLAVGNLHNLFTLNNRTGELRTGGSFADYV-DGYFLMRVMANNSVQP 1615
            |     :..|..:|     :..||....|.::..:||:.|..:..|.. ..::.:.....:...|
Human  1558 G-----INSVLSYY-----ITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTP 1612

  Fly  1616 KRQAHSNLKVFVIRDKSLLKFVFARPPNEIQHNIRPFQEQLQKKLKPLGLELHVLDTQVFTRPDM 1680
            ...|.:::.|.:: |::....:|.:|..|:..:..|                ..|:|.:.|...:
Human  1613 TLSATTHVYVTIV-DENDNAPMFQQPHYEVLLDEGP----------------DTLNTSLITIQAL 1660

  Fly  1681 SLDFTATSSCFQMFKNGAALSFNEMQKLMNSQQLRQELIDIYAA----YGVSEVE-SCSVRRTHA 1740
            .||         ...||..........::|:.::.:.:..|.||    |.:|... :..|..|..
Human  1661 DLD---------EGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQ 1716

  Fly  1741 AAIFAGMLTSAGAWLV 1756
            ..|.:..|||....||
Human  1717 CPILSHRLTSTTTVLV 1732

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_648973.1 Cadherin_repeat 33..124 CDD:206637 36/95 (38%)
Cadherin_repeat 132..240 CDD:206637 30/110 (27%)
Cadherin_repeat 249..361 CDD:206637 33/113 (29%)
Cadherin_repeat 487..581 CDD:206637 34/93 (37%)
Cadherin_repeat 589..686 CDD:206637 34/99 (34%)
Cadherin_repeat 713..810 CDD:206637 34/102 (33%)
Cadherin_repeat 819..936 CDD:206637 28/132 (21%)
Cadherin_repeat 953..1049 CDD:206637 23/98 (23%)
Cadherin_repeat 1057..1166 CDD:206637 28/115 (24%)
Cadherin_repeat 1175..1279 CDD:206637 31/105 (30%)
Cadherin_repeat 1293..1390 CDD:206637 40/198 (20%)
Cadherin_repeat 1402..1513 CDD:206637 29/110 (26%)
Cadherin_repeat 1523..1628 CDD:206637 21/105 (20%)
CDH23NP_071407.4 Cadherin_repeat 42..128 CDD:206637 36/92 (39%)
Cadherin_repeat 136..231 CDD:206637 30/110 (27%)
Cadherin_repeat 240..344 CDD:206637 33/113 (29%)
Cadherin_repeat 352..456 CDD:206637 40/112 (36%)
Cadherin_repeat 465..557 CDD:206637 34/92 (37%)
Cadherin_repeat 566..667 CDD:206637 36/117 (31%)
Cadherin_repeat 676..774 CDD:206637 35/102 (34%)
Cadherin_repeat 782..886 CDD:206637 27/131 (21%)
Cadherin_repeat 894..990 CDD:206637 22/107 (21%)
Cadherin_repeat 999..1098 CDD:206637 28/115 (24%)
Cadherin_repeat 1106..1203 CDD:206637 31/106 (29%)
Cadherin_repeat 1218..1308 CDD:206637 12/89 (13%)
Cadherin_repeat 1317..1414 CDD:206637 28/97 (29%)
Cadherin_repeat 1426..1523 CDD:206637 29/107 (27%)
Cadherin_repeat 1533..1630 CDD:206637 22/112 (20%)
Cadherin_repeat 1638..1740 CDD:206637 23/120 (19%)
Cadherin_repeat 1752..1847 CDD:206637
Cadherin_repeat 1855..1955 CDD:206637
Cadherin_repeat 1963..2065 CDD:206637
Cadherin_repeat 2075..2169 CDD:206637
Cadherin_repeat 2180..2289 CDD:206637
Cadherin_repeat 2301..2398 CDD:206637
Cadherin_repeat 2406..2504 CDD:206637
Cadherin_repeat 2513..2607 CDD:206637
Cadherin_repeat 2620..2718 CDD:206637
Cadherin_repeat 2735..2841 CDD:206637
Cadherin_repeat 2850..2951 CDD:206637
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.