Protein Alignment Cad74A and LOC5666925

DIOPT Version :10

• Sequence 1: NP_648973.1
• Gene: Cad74A / 39936
• FlyBaseID: FBgn0036715
• Length: 1820
• Species: Drosophila melanogaster
• Sequence 2: XP_061508255.1
• Gene: LOC5666925 / 5666925
• VectorBaseID: AGAMI1_010187
• Length: 1143
• Species: Anopheles gambiae
• Alignment Length: 1031
• Identity: 239/1031 - (23%)
• Similarity: 376/1031 - (36%)
• Gaps: 290/1031 - (28%)

  Fly   342 IPAEHSLTRVTIVVTDVDDHQPTF----SGP--------HFNVSITENLANGMPLPGLSIFVD-- 392
            |.|::.....||.:|...::.|:|    |.|        .||.:|.|..||.....|.||..|
Mosquito    24 IQAKNEAANDTISLTVDSNYIPSFTKIPSAPIALNETYDLFNTAIAELEANTNLNDGTSIIFDLA 88

  Fly   393 -DRDMGENSRYELSLRDVFNAARVFEVSPTESQGRTPVVVKVLNASRLDYDVVDPDLRKFEFDLV 456
             |.|...|.:....|..|.|.|                .:|:  ..:|||:.|    :::...:.
Mosquito    89 LDNDATSNIQNTFILEQVNNTA----------------YIKL--GGKLDYEKV----QEYRITVR 131

  Fly   457 A-SVKGVEKAKTRVEIHLLDANDNAPVFDQGTYRFTAAENLPVDAIIGHVKATDLDSGEFGH--V 518
            | :|||: ||:..|.|.:||.|||.|.. .|.:.....|:.|....:..|||.|.| |...|  |
Mosquito   132 AMNVKGL-KAEAVVLIKILDENDNIPEI-IGDWNGVILEHEPAGTFVMQVKAHDND-GTSAHNIV 193

  Fly   519 RYVLKGFGADNFYVNPETGGVYLLKPLDYEKQSSYSLTVVAID---------GGQREANANLFVG 574
            .|.|:|.....|:::.:||.:..|...|.|.:..|.:||||.|         |....|...||:.
Mosquito   194 SYRLEGTARQYFHIDSKTGNITSLVEFDREAKDIYPVTVVAEDNSPSVLFNNGKPNSAVKQLFIR 258

  Fly   575 VTDVNDNHPNFESKEYS-RTIREGAALFEPQFFVRAHDADGPSQGNGRVKYSIVSENSIAGNVFR 638
            |.|.||:.|.|:.:.|. .:|.|.|.:......|:|.|.|    .:.::||||: ||:| |..::
Mosquito   259 VLDKNDHPPQFDEQYYEVDSIPEDADINTSVIKVKATDLD----KDPKIKYSII-ENNI-GKAYK 317

  Fly   639 IEPDTGEIVIQKAARSMDTER-GEYELVVSATDFGIPPLSNTTRVLVRVGISGNQRPIFRGHFQN 702
            |:.|||.|.:.|   .:|.|. .||:|||.|.| |:  ..:||.|.:::
Mosquito   318 IDEDTGLISVNK---KLDYESIQEYDLVVQAHD-GL--FKSTTNVRIQI---------------- 360

  Fly   703 MENLPIIGPPSY---RVSIPENAAAGSNVTSVSAHDPDGLDSLLRYRIVGANDNFE--------- 755
             :||..|.|...   .|:|.||......:.::.|:|||             .:|||
Mosquito   361 -KNLNDIAPQILTLTNVTIKENTIPSDCIANLWAYDPD-------------IENFEYPQNIQYAL 411

  Fly   756 ---------IDEISGLITVSPQARIDRD--SNMNSFEIIVNAVDSGTPIPETATTTVYVNVKDIN 809
                     ||:...|..:.|   :|||  ......:|.:...|.... ..||..|||:.|:|||
Mosquito   412 PKEHQHLLSIDDKGCLKLLQP---LDRDPPHGHEVLQIDITITDENGK-GRTAMETVYIFVEDIN 472

  Fly   810 DERPKFEQNSYATYVSERTAVGESVLRVKAIDKDLNSKLEYSMVGPVAATTKAGVSIANRSN--- 871
            |..|:........:...|.:...:.|..:..|.:.|....:..|.|.|.|     .|.||..
Mosquito   473 DNAPQLTNRMPVVWSENRPSAMITKLTAEDADGEHNGPPFFYSVDPDAPT-----EIKNRFQTVG 532

  Fly   872 ---YRLQEAFRVDSQS--GEIFVNGTLRHDVAAIIIFTVGVRDLNAEVDPEGQVDTTEVTV--YV 929
               |.|.|..|...:.  ..|.:..:....::|:....|.:.|.|   |.|.|:..:.:.|  |.
Mosquito   533 DELYSLVEFDREQQKQYLVPILIRDSGHKPMSAVSKLLVVIGDKN---DNEMQMGQSHILVNNYE 594

  Fly   930 QSFQDTNPVFKNTGWTSSRPVIDVKIKEEMPIDSALFILQAEDPVTRQPITSFELIEPKQVDYFQ 994
            ....||     ..|      ::.|...::..:...:|:.....|.|.:.:             |:
Mosquito   595 GKLADT-----QIG------LVYVSDPDDWDVSDKMFLWDEMTPETNRKL-------------FK 635

  Fly   995 VAERTGEVILKK-------RLDYEALGDTG--PEFELQVRANSADRQRSTVSRVNITVENVND-- 1048
            :...||.:.::|       .|::..:.::.  |...:..|.        ||:..|||.:.||.
Mosquito   636 LNINTGIITMRKGTPEGIYNLEFTVIEESSYFPRHNVSARV--------TVTVKNITAKTVNQSG 692

  Fly  1049 --------------------NSPRFERNSYQATIIENRP--------HPERVIRVRALD------ 1079
                                |:|.:......|:|::..|        :..:::|...||
Mosquito   693 SVRFYNVTAETFISQTLGELNTPMYRLQQSIASILDTSPDQVDIFTINNRKLVRGAFLDVFFAVD 757

  Fly  1080 -----KDAVLNA--------RDERLGYHKIIYS----LQGEHAMLFDINN----TTGEIIVASGQ 1123
                 ...||||        .:|.:||..::..    |:..|.......|    |...|:|.:..
Mosquito   758 DTIYTSSEVLNAVLSLHLRQLEEDVGYRIVMVGIDECLEKGHTCTQTCKNKVLKTAKPIVVHTNT 822

  Fly  1124 T--------IDRERTPRIQLQIKAEDSPGRPTDAK----QSVVELQIEVLDVNDNAPEFTQKKYS 1176
            |        :..|..|:|:..:.|..:.|...:.|    ......|.|.||:
Mosquito   823 TSFVGMTTLVQAECIPQIESSLVACFNGGTFQNGKCKCPMGFEGPQCEKLDI------------- 874

  Fly  1177 TVIPENAQIDSFVLQLEAVDADEGLGGEVRYELVNEGEANGLFKID----TKSGLI 1228
                                ..:|:|..: |..:|.|..|.: .|:    .|.||:
Mosquito   875 --------------------CFDGIGYAI-YPSINSGNINNV-SIELLPRQKDGLV 908

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad74A	NP_648973.1	Cadherin_repeat	33..124	CDD:206637
		Cadherin_repeat	132..240	CDD:206637
		Cadherin_repeat	249..361	CDD:206637	5/18 (28%)
		Cadherin_repeat	487..581	CDD:206637	32/104 (31%)
		Cadherin_repeat	589..686	CDD:206637	35/98 (36%)
		Cadherin_repeat	713..810	CDD:206637	28/119 (24%)
		Cadherin_repeat	819..936	CDD:206637	26/126 (21%)
		Cadherin_repeat	953..1049	CDD:206637	18/126 (14%)
		Cadherin_repeat	1057..1166	CDD:206637	30/155 (19%)
		Cadherin_repeat	1175..1279	CDD:206637	10/58 (17%)
		Cadherin_repeat	1293..1390	CDD:206637
		Cadherin_repeat	1402..1513	CDD:206637
		Cadherin_repeat	1523..1628	CDD:206637
LOC5666925	XP_061508255.1	None