DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad74A and fat1b

DIOPT Version :9

Sequence 1:NP_001246814.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:XP_021328497.1 Gene:fat1b / 565591 ZFINID:ZDB-GENE-130530-563 Length:4503 Species:Danio rerio


Alignment Length:1907 Identity:489/1907 - (25%)
Similarity:788/1907 - (41%) Gaps:410/1907 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 VGSPVFQLKGTDPEGGRLKYSISGP--VFSVDRETGVV-RLRQELDRETQDTVEVIISITDE-GI 102
            |..|:|             |||..|  .|.:.|.:||: ......|||.||..|:|:.:..| |:
Zfish  2033 VNEPLF-------------YSILNPNSKFEIGRTSGVLFSTGIPFDREEQDLFEIIVEVIKEPGL 2084

  Fly   103 YGTEPNTVSQRRVIPVRDYNDNQPTFLGRPYTASVSESLPVGSELSVEPPIVVVDRDEGINSEVQ 167
            .|.....|.    :.|.|.|||.|.|:.:||.|.|.....||   ||...:..||||.|.|:|:.
Zfish  2085 NGPAHVLVK----VQVEDVNDNAPFFVDQPYHAVVQVDQTVG---SVFAKVTTVDRDIGKNAEIT 2142

  Fly   168 MKCLEENDICDIFEVRAVKISDGNYTARVALKQQLDFESRPSYILTISASDSALDNRLSSLATIS 232
            . .|:.:|  ..|:|        |....::||:.|:.||...|::.|:|.|.. :..|.|.|.:.
Zfish  2143 Y-YLKGHD--KYFQV--------NPFGEISLKRPLELESIGKYVINITAQDEG-EPPLFSNAEVV 2195

  Fly   233 INVIDIQDQPPIFTNAPYSATVPENTPAGVSILTVKAVDGDVGIPREIFLSLEDEPFGHFELVPF 297
            |:|::  ...|||....|...:.||...|.|||.|.| :...| ||.::......||..|::   
Zfish  2196 ISVVN--KATPIFERPFYKIEILENVLVGTSILQVVA-NQSAG-PRTVYSISGGNPFSQFDI--- 2253

  Fly   298 GDPRDGTAVLQTTSEPLDRENAEILQNGGVYVFSIRATELIDGAIPAEHSLTRVTIVVTDVDDHQ 362
                ...:.|....:|||.|...      .|..||:||:.:.||    :|...|.|::.||:|:.
Zfish  2254 ----HFNSGLIKVIQPLDYEAHP------AYRLSIQATDSLTGA----NSDVFVDIILEDVNDNA 2304

  Fly   363 PTFSGPHFNVSITENLANGMPLPGLSIFVDDRDMGENS--RYELSLRD----------------- 408
            |.|....:::||:|:...|..:  |.:...|.|...|:  .|:|..||                 
Zfish  2305 PKFEAAVYSISISESTVIGTSV--LQVVAMDPDAQSNAILFYKLHERDGSTSDHFRIDAETGVIW 2367

  Fly   409 --------------------------------------------------VFNAARVFEVSPTES 423
                                                              ::||.    :|...|
Zfish  2368 TAGLLDHETQSQHDLIVKAVDGGAIQLSSEVQVTVYITDLNDNPPIFAQQLYNAT----ISKISS 2428

  Fly   424 QGRTPVVVKVLNA-----SRLDYDVVD-----------------------PDLRKFEFDLVASV- 459
            .|:....||..:|     |.|:|.::.                       ..|:.| :.|:.|| 
Zfish  2429 PGQLVTCVKAFDADSHGSSNLEYAILSGNDNNIFAIDALSGEIVIANISRQSLKHF-YSLILSVT 2492

  Fly   460 KGVEKAKTRVEIHLLDANDNAPVFDQGTYRFTAAENLPVDAIIGHVKATDLDSGEFGHVR-YVLK 523
            .||..|.....|:::..|.::|.|.|..|....|||.||..::|.|:|.|.|.|::|.:. :::.
Zfish  2493 DGVFCASAEANIYVMGENSHSPSFTQDEYLIELAENSPVGTLVGQVEAIDEDPGKYGQLTFFIMN 2557

  Fly   524 GFGADNFYVNPETGGVYLLKPLDYE--KQSSYSLTVVAIDGGQREANANLFVGVTDVNDNHPNFE 586
            ....|.|.:| |.|.:|..:..|.|  ::....::::|.|||......|:.|.::|||||.|.|:
Zfish  2558 DIARDKFNIN-EDGQIYTEESFDRENPEEKIIRISLMAKDGGGLLGFCNVIVILSDVNDNSPKFK 2621

  Fly   587 SKEYSRTIREGAALFEPQFFVRAHDADGPSQGNGRVKYSIVSENSIAGNVFRIEPDTGEIVIQKA 651
            ..||..|:...|..........|.|.|..|  |..:.|:|.|:.    :.|.|...:|.||.:::
Zfish  2622 HSEYKVTVPRDAPSSTTVIKTTAVDEDEGS--NADIVYTIESDI----DHFEIHSLSGAIVTKES 2680

  Fly   652 ARSMDTERGEYELVVSATDFGIPPLSNTTRVLVRVGISGNQRPIFRGHFQNMENLPIIGPPSYRV 716
            .  :..|.|.|...|.|.|.|.||..:...|.:|:             .....::|....||..:
Zfish  2681 L--IGLENGLYSFFVKAKDSGSPPKQSIIPVSIRI-------------VPPETSIPKFAEPSLWL 2730

  Fly   717 SIPENAAAGSNVTSVSAHDPDGLDSLLRYRIVGAN-------DNFEIDEISGLITVSPQARIDRD 774
            .:.|:.|.|:.:....|.:    :..:.|.:||.|       |.|.||..:|.:.::  .|:|.:
Zfish  2731 ELSEDLAVGTEMDIFQAEN----ELSVIYSLVGGNTPESNKHDVFAIDSTTGKLILT--KRLDYE 2789

  Fly   775 SNMNSFEIIVNAVDSGTPIPETATTTVYVNVKDINDERPKFEQNSYATYVSERTAVGESVLRVKA 839
            : :..:.:.|...|....:...:|..|.|::||:||..|:||...|.:.::|....|.||::|||
Zfish  2790 T-IKWYHLAVQVRDVKDDMEMISTVDVSVHLKDVNDNSPQFESFRYQSCIAENLPKGTSVVQVKA 2853

  Fly   840 IDKD--LNSKLEYSMVGPVAATTKAGVSIANRSNYRLQEAFRVDSQSG------EIFVNGTLRHD 896
            .|.|  ||.::.|::             ..|:....:.:.|.|:|::|      ||....|.::.
Zfish  2854 TDLDSWLNGQITYAL-------------HENQQPPDVLQLFSVNSETGWITTLMEIDREKTDQYR 2905

  Fly   897 VAAIIIFTVGVRDLNAEVDPEGQVDTTEVTVYVQSFQDTNPVFKNTGWTSSRPVIDVKIKEEMP- 960
            :.  ::.|.|.:.|.       ...||.|.|.|....|..|:|....:..:     |:..|..| 
Zfish  2906 IT--VVATDGAQGLQ-------MTGTTVVEVTVVDTNDNPPLFTEAVFKGA-----VREDESTPG 2956

  Fly   961 --IDSALFILQAEDPVTRQ---PITSFE---LIEPKQVDYFQVAERTGEVILKKRLDYEALGDTG 1017
              :....::....|.|.|:   .||..:   |.:.|..|...|      |.:.|.||.|.     
Zfish  2957 TVVTILSYVDSDSDEVNRRFNCFITGGDPQGLFDVKHTDGVWV------VAVSKTLDREE----- 3010

  Fly  1018 PEFELQVRANSADRQRSTVSRVNITVENVNDNSPRFERNSYQATIIENRPHPERVIRVRALDKDA 1082
            .:|.| :...:.|......:.|.|||.:.|||||..|::.|...:.|:....:.:::|.|.|.|.
Zfish  3011 RDFYL-LNITATDGTFVAKAAVEITVLDANDNSPVCEKDVYAQAVPEDVLIGKHILQVSATDADI 3074

  Fly  1083 VLNARDERLGYHKIIYSLQGEHAMLFDINNTTGEIIVASGQTIDRERTPRIQLQIKAEDSPGRPT 1147
            ..||        :|.|.|.|..|..|.|::.||.:...:  |:|||.|....|.::|.|......
Zfish  3075 QSNA--------EITYQLSGSGAESFTIDSKTGAVKTLA--TLDREVTDVYNLTVRAVDKDNHFC 3129

  Fly  1148 DAKQSVVELQIEVLDVNDNAPEFTQKKYSTVIPENAQIDSFVLQLEAVDADEGLGGEVRYELVNE 1212
            .|     .|.|.|.|.|||||:||...:...|.:|.|..::|.:|||.|||.|:.|::||..  |
Zfish  3130 QA-----SLLITVEDANDNAPKFTSDPHHVSIYQNTQPGTYVARLEAFDADIGMNGKIRYSF--E 3187

  Fly  1213 GEANGLFKIDTKSGLISTRRNLTGKGRAHPYVLIVRAQDNGNQMPKQPTLSTDTDVRIYIGDVSA 1277
            ..|.|||.|:..||:||..|:|..:.:| .:||.|||.|.|  .|.:  ||:...|.:.:.|  |
Zfish  3188 DSAGGLFSIEESSGIISLERSLDKQMKA-MHVLRVRATDQG--FPHR--LSSLGSVLVTVLD--A 3245

  Fly  1278 NDGVPYFLSPRVGQMANVTENAVTGAPVFQVIASDPDDESTPSGTITYRILPDTPDAEAFVIDAH 1342
            ||..|.|  .|...::.|.|:...|..:.:|.||..|.:.|...|.::   ....:..||.||:.
Zfish  3246 NDHPPVF--ERREYISTVPEDVTIGTKLLKVFASSKDRQMTSQTTYSF---SSGNEQGAFRIDSQ 3305

  Fly  1343 SGLITTRQSMDRETKDMYRILLEVSDNGQPKQSATRILQIAILDVDDHEPRFAREADAGPLSMSV 1407
            :|.|...:.:|.|....:.:.::.:..|:...|....:.|.:.|::|:.|.|:::..:..:|...
Zfish  3306 TGDIFVMEPLDYEESSQHYLTVKATVGGKQSLSDMATVSIHLQDINDNSPVFSQKIYSAVVSEDT 3370

  Fly  1408 REEEPAGTIVGNFSALDEDLGENAAIDYVIIDG--NNEQLFTIERNNESLAI--------LKTKK 1462
            |......|::.|      ||           ||  ||:..::||.:|:|...        |:..:
Zfish  3371 RLASTVLTVLAN------DL-----------DGPLNNQIRYSIEESNQSCPFIMDAVSGELQLAR 3418

  Fly  1463 PIDREQVESFTLTIKCLKLGEPGYKFIGDPYDRQDLSHLRINVRVLDIDDNLPKFEQPDPTVGIR 1527
            .:|||.|.|:.||:.....|.|         .:.|.:  .||:.|.|::||.|.|.|.:.::.|:
Zfish  3419 QLDREMVASYMLTVMASDSGSP---------LKSDSA--AINIAVSDVNDNPPVFSQANYSLIIQ 3472

  Fly  1528 INVPIDTVVTTLKASDADA--EAPPVGLSIENVTFVPQFYKRSRSLAVGNLHNLFTLNNRTGELR 1590
            .|:|..|.|..|..:|.|:  ..||...                 :.:|...|.|:::.: |.::
Zfish  3473 ENLPSGTSVLQLNVTDNDSLHNGPPFSF-----------------ILIGVEANPFSIDQQ-GLVK 3519

  Fly  1591 TGGSFADYVDGYFLMRVMANNSVQPKRQAHSNLKVFVIRDKSLLKFVFARPPNEIQHNIRPFQEQ 1655
            |.|..   ..|.:.::|..:::.:|.:::.:::.|.|.:.......||   |.||      |...
Zfish  3520 TAGPL---TKGQYTLQVQVSDNGKPPQKSVTSITVLVAQASMFPPSVF---PLEI------FIIL 3572

  Fly  1656 LQKKLK--PLGLELHVLDTQVFTRPDMSLDFTATSSCFQMFKNGAAL------------------ 1700
            |:.:..  .|| ::|..|.....:...||| ..:.|.|.:......|                  
Zfish  3573 LEDEYSGGTLG-KIHATDQDEHDKLAFSLD-PQSHSLFSIIGTDGRLLAREGLDVGHYQLNVSVS 3635

  Fly  1701 ----SFNEMQKLMNSQQLRQELIDIYAAYGVSEVESCSVRRTHAAAIFAGMLTS---AGAWLVFL 1758
                |.:.:.| :|..|:.::::|          .|.|:|       |||:.|.   ...|..|.
Zfish  3636 DGHFSVSSIVK-VNVLQVTEQMLD----------SSISIR-------FAGITTEDFIQDHWKNFQ 3682

  Fly  1759 AALIGLAA-------LVSLCTA 1773
            ..|..:|.       |:||.:|
Zfish  3683 KMLRSVAGARRGAINLISLQSA 3704

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_001246814.1 Cadherin_repeat 33..124 CDD:206637 25/85 (29%)
Cadherin_repeat 132..240 CDD:206637 34/107 (32%)
Cadherin_repeat 249..361 CDD:206637 32/111 (29%)
Cadherin_repeat 369..479 CDD:206637 33/207 (16%)
Cadherin_repeat 487..581 CDD:206637 30/96 (31%)
Cadherin_repeat 589..686 CDD:206637 27/96 (28%)
Cadherin_repeat 713..810 CDD:206637 23/103 (22%)
Cadherin_repeat 819..936 CDD:206637 30/124 (24%)
Cadherin_repeat 953..1049 CDD:206637 25/104 (24%)
Cadherin_repeat 1057..1166 CDD:206637 31/108 (29%)
Cadherin_repeat 1175..1279 CDD:206637 40/103 (39%)
Cadherin_repeat 1293..1390 CDD:206637 21/96 (22%)
Cadherin_repeat 1402..1513 CDD:206637 29/120 (24%)
Cadherin_repeat 1523..1628 CDD:206637 20/106 (19%)
fat1bXP_021328497.1 Cadherin_repeat 45..150 CDD:206637
Cadherin_repeat 159..259 CDD:206637
E_set 272..359 CDD:324323
Cadherin_repeat 377..467 CDD:206637
Cadherin_repeat 476..573 CDD:206637
Cadherin_repeat 584..673 CDD:206637
Cadherin_repeat 729..826 CDD:206637
Cadherin_repeat 834..931 CDD:206637
Cadherin_repeat 939..1036 CDD:206637
Cadherin_repeat 1050..1143 CDD:206637
Cadherin_repeat 1151..1249 CDD:206637
Cadherin_repeat 1273..1347 CDD:206637
Cadherin_repeat 1365..1477 CDD:206637
Cadherin_repeat 1485..1583 CDD:206637
Cadherin_repeat 1591..1687 CDD:206637
Cadherin_repeat 1696..1786 CDD:206637
Cadherin_repeat 1794..1899 CDD:206637
Cadherin_repeat 1908..1996 CDD:206637
Cadherin_repeat 2008..2102 CDD:206637 25/85 (29%)
Cadherin_repeat 2110..2199 CDD:206637 33/103 (32%)
Cadherin_repeat 2211..2303 CDD:206637 32/110 (29%)
Cadherin_repeat 2311..2410 CDD:206637 12/100 (12%)
Cadherin_repeat 2419..2512 CDD:206637 21/97 (22%)
Cadherin_repeat 2520..2616 CDD:206637 30/96 (31%)
Cadherin_repeat 2624..2714 CDD:206637 28/110 (25%)
Cadherin_repeat 2730..2825 CDD:206637 23/101 (23%)
Cadherin_repeat 2838..>2915 CDD:206637 22/91 (24%)
Cadherin_repeat 2943..3041 CDD:206637 25/114 (22%)
Cadherin_repeat 3054..3143 CDD:206637 30/103 (29%)
Cadherin_repeat 3153..3248 CDD:206637 41/103 (40%)
Cadherin_repeat 3256..3353 CDD:206637 21/99 (21%)
Cadherin_repeat 3361..3458 CDD:206637 29/124 (23%)
Cadherin_repeat 3467..3553 CDD:206637 20/106 (19%)
Cadherin_repeat 3567..3652 CDD:206637 17/93 (18%)
Laminin_G_2 3881..4001 CDD:308045
EGF 4033..4064 CDD:306513
EGF_CA 4069..4104 CDD:238011
EGF 4109..4139 CDD:306513
EGF_CA 4143..4179 CDD:238011
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24026
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
33.010

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