DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad74A and celsr1b

DIOPT Version :9

Sequence 1:NP_001246814.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:XP_001920772.2 Gene:celsr1b / 556520 ZFINID:ZDB-GENE-050823-4 Length:3006 Species:Danio rerio


Alignment Length:1545 Identity:376/1545 - (24%)
Similarity:594/1545 - (38%) Gaps:431/1545 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   243 PIFTNAPYSATVPENTPAGVSILTVKAV---DGDVGIPREIFLSLEDEPFGH-FELVPFGDPRDG 303
            |.|....|..:||||.|:|..::|:||.   |||.|:......:|.|....: |::    :|..|
Zfish   237 PQFQLPNYQVSVPENEPSGTRVITLKAFDADDGDAGVVVYDMEALFDSRSNNLFQI----NPETG 297

  Fly   304 TAVLQTTSEPLDRENAEILQNGGVYVFSIRATELIDGAIPAEHSLTRVTIVVTDVDDHQPTFSGP 368
            ..   ||.:|||||..:      .:||.:.||   |..||...::..:||.|:|.:||.|.|...
Zfish   298 GI---TTLQPLDREVKD------THVFKVTAT---DKGIPKRSAIAYLTITVSDTNDHSPVFEQN 350

  Fly   369 HFNVSITENLANGMPLPGLSIFVDDRDMGENSR--YELSLRDVFNAARVFEVSPTESQGRTPVVV 431
            .:.|::.||:..|..:  ::|...|.|...|:.  |::...|..|:.  ||:.|.....||.|  
Zfish   351 EYRVNVRENVEVGFEV--MTIRATDGDAPSNANMIYKIVNDDEVNSC--FEIDPRNGLVRTKV-- 409

  Fly   432 KVLNASRLDYDVVDPDLRKFEFDLVASVK------GVEKAKTRVEIHLLDANDNAPVFDQGTYRF 490
                  |.|.:|      |.::.|.....      |...|...|.|.:.|.|||.|.|.:..|..
Zfish   410 ------RPDREV------KSQYKLFVEANDQGREPGPRTATATVHIFIEDENDNYPQFSEKRYVV 462

  Fly   491 TAAENLPVDAIIGHVKATDLDSGEFGHVRY-VLKGFGADNFYVNPETGGVYLLKPLDYEKQSSYS 554
            ..:||:.|:..:..|||||.|:|....|.| ::.|.....||::..||.:.::.|||||....|:
Zfish   463 QVSENIAVNTQVAVVKATDKDAGNNAKVHYSIINGNIKGQFYIHSPTGVIDVVSPLDYEMIREYT 527

  Fly   555 LTVVAIDGGQR---EANANLFVGVTDVNDNHPNFESKEYSRTIREGAALFEPQFFVRAHDADGPS 616
            |.|.|.|||:.   .....:.:.|.|||||.|.|.|..:..::.|...:......::|.|||  |
Zfish   528 LRVKAQDGGRPPLINGTGMVVIQVVDVNDNAPMFVSTPFQASVLENVPIGYSVIHIQAIDAD--S 590

  Fly   617 QGNGRVKYSIVSENSIAGNVFRIEPDTGEIVIQKAARSMDTERGE-YELVVSATDFGIPPLSNTT 680
            ..|..::|.:.  ::..|..|.|...||.:.:   :..:|.|..| |...|.|.|.|:|.:|::.
Zfish   591 GDNAHLEYKLT--DTSPGFPFVINNSTGWVTV---SAELDRETTEFYSFGVEARDHGVPTMSSSA 650

  Fly   681 RVLVRVGISGNQRPIFRGHFQNMENLPIIGPPSYRVSIPENAAAGSNVTSVSAHDPDGLDSLLRY 745
            .|.|.:....:..|.|..|.             |.:.:.|:|..|::|.:|||.|.| ::|::.|
Zfish   651 SVSVTILDVNDNVPTFTQHL-------------YNLKVNEDAVVGTSVLTVSAVDRD-VNSVVTY 701

  Fly   746 RIVGAN--DNFEIDEIS--GLITVSPQARIDRDSNMNSFEIIVNAVDSGTPIPETATTTVYVNVK 806
            :|...|  :.|.|...|  ||||::    :..|.......::......||   ...||.|::||.
Zfish   702 QISSGNTRNRFAISSQSGGGLITLA----LPLDYKQERQYLLTITASDGT---RHDTTQVFINVT 759

  Fly   807 DINDERPKFEQNSYATYVSERTAVGESVLRVKAIDKDL--NSKLEYSMVGPVAATTKAGVSIANR 869
            |.|..||.|:..:|...|||...||.:|:.:.|.|:|.  |:::.|.|...|             
Zfish   760 DANTHRPVFQSANYQVLVSEDRPVGSTVVVISATDEDTGENARITYVMEDNV------------- 811

  Fly   870 SNYRLQEAFRVDSQSGEIFVNGTLRHDVAAIIIFTVGVRDLNAEVDPEGQVDTTEVTVYVQSFQD 934
                  ..||:|..:|.|                                  ||::         
Zfish   812 ------PQFRIDPDTGAI----------------------------------TTQI--------- 827

  Fly   935 TNPVFKNTGWTSSRPVIDVKIKEEMPIDSALFILQAEDPVTRQPITSFELIEPKQVDYFQVAERT 999
                                                                  ::||...|..|
Zfish   828 ------------------------------------------------------EIDYEDQASYT 838

  Fly  1000 GEVILKKRLDYEALGDTG-PEFELQVRANSADRQRSTVSRVNITVENVNDNSPRFERNSYQATII 1063
            ..:|.:         |.| |             |:|..:.|.|.|.:.|||.|:|.|:.||.|:.
Zfish   839 LAIIAR---------DNGIP-------------QKSDTTYVEIIVLDANDNVPQFLRDIYQGTVF 881

  Fly  1064 ENRPHPERVIRVRALDKDAVLNARDERLGYHKIIYSLQG--EHAMLFDINNTTGEIIVASGQTID 1126
            |:.|....|::|.|.|:|:..|.|        :.|:.||  :....|.|...:|  |:.:.:.:|
Zfish   882 EDAPVYTSVLQVSASDRDSGSNGR--------LSYTFQGGDDGEGDFFIEPYSG--IIRTARKLD 936

  Fly  1127 RERTPRIQLQIKAEDSPGRPTDAKQSVVELQIEVLDVNDNAPEFTQKKYSTVIPENAQIDSFVLQ 1191
            ||......|:..|.|....|..|   .|::|:.|||:|||||.|.:.:....:.||:.:.|.:.:
Zfish   937 RENVALYTLKAFAVDKGVPPLKA---AVDIQVSVLDINDNAPVFEKDELYIYVEENSAVGSTLAR 998

  Fly  1192 LEAVDADEGLGGEVRYELVNEGEANGLFKIDTKSGLISTRRNLTGKGRAHPYVLIVRAQDNGNQM 1256
            :.|.|.|||...::.|::| ||....:|::|..||.:....:|..:.:.. ||::|:|       
Zfish   999 VSATDPDEGTNAQILYQIV-EGNFPEVFQLDIFSGDLIALTDLDYETKME-YVIVVQA------- 1054

  Fly  1257 PKQPTLSTDTDVRIYIGDVSANDGV----PYFLSPRVGQMANVTENAVTGAPVFQVIASDPDDES 1317
            ...|.:|..| |.:.:.||:.||.|    ....:..:...::...|.|.|    :|.|.|||   
Zfish  1055 TSAPLVSRAT-VHVLLVDVNDNDPVLQDFEIIFNNYITNKSSSFPNGVIG----KVPARDPD--- 1111

  Fly  1318 TPSGTITYRILPDTPDAEAFVIDAHSGLITTRQSMD--RETKDMYRILLEVSDNGQPKQSATRI- 1379
             .|..:.|          .||.....||:...|...  :.:||:        ||.:|.::..|: 
Zfish  1112 -VSDKLIY----------TFVEGNELGLLILNQDTGELKLSKDL--------DNNRPLEALMRVT 1157

  Fly  1380 -------------LQIAILDVDD-------------HEPRFA-------READAGPLSMS----- 1406
                         |::.|: .||             .:.||.       .|..|..||.|     
Zfish  1158 VSDGLHQVSALCTLRVTII-TDDMLTNSITVRLENMSQERFLSPLLSLFAEGVAAVLSTSPDGIF 1221

  Fly  1407 ----VREEEPAGTIVG-NFSALDEDLGENAAIDYVIIDGNNEQLFTIERNNESLAILKTKK--PI 1464
                ..:.:.:|:|:. .||||   |...|...|...:...|||:.   |...|.::.|::  |.
Zfish  1222 IFNVQNDTDVSGSILNVTFSAL---LPGGAPGRYFPSEELQEQLYL---NRTLLMLISTQRVLPF 1280

  Fly  1465 D-----REQVESFTLTIKCLKLGEPGYKFIGDPYDRQDLSHLRINVRVLDIDDNLP-------KF 1517
            |     ||..|::   :||                          |.||..|...|       .|
Zfish  1281 DDNICLREPCENY---MKC--------------------------VAVLKFDSTAPFVASNTVLF 1316

  Fly  1518 EQPDPTVGIRINVP-----------IDTVVTTLKASDADAEAPPVGLSIENVTFVPQFYKRSRSL 1571
            ....|..|:|...|           :|...:....::....:...|.:.|    .||.:...|. 
Zfish  1317 RPIHPVNGLRCRCPDGFTGDYCETEVDLCYSGPCQNNGKCRSKEGGYTCE----CPQDFTGERC- 1376

  Fly  1572 AVGNLHNLFTLNNRTGE-----LRTGGSFADYVDGYFLMRVMANNSVQP---------------- 1615
                     .:|.|:|.     .:.||...|.:.|.|:.:.......:|                
Zfish  1377 ---------EVNARSGRCVPGVCKNGGRCLDLLVGGFMCQCPDGEYEKPYCQMSTRSFPGQSFIT 1432

  Fly  1616 ----KRQAHSNLK-VFVIRDKSLLKFVFARPPNEIQHN---IRPFQEQLQ 1657
                :::.|..|. :|..|:::.|.....| .|| :|:   |...:||:|
Zfish  1433 FRGLRQRFHFTLSFMFATRERNALLLYNGR-FNE-KHDFIAIEIVKEQIQ 1480

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_001246814.1 Cadherin_repeat 33..124 CDD:206637
Cadherin_repeat 132..240 CDD:206637
Cadherin_repeat 249..361 CDD:206637 37/115 (32%)
Cadherin_repeat 369..479 CDD:206637 28/117 (24%)
Cadherin_repeat 487..581 CDD:206637 34/97 (35%)
Cadherin_repeat 589..686 CDD:206637 25/97 (26%)
Cadherin_repeat 713..810 CDD:206637 30/100 (30%)
Cadherin_repeat 819..936 CDD:206637 21/118 (18%)
Cadherin_repeat 953..1049 CDD:206637 14/96 (15%)
Cadherin_repeat 1057..1166 CDD:206637 33/110 (30%)
Cadherin_repeat 1175..1279 CDD:206637 27/103 (26%)
Cadherin_repeat 1293..1390 CDD:206637 25/125 (20%)
Cadherin_repeat 1402..1513 CDD:206637 29/127 (23%)
Cadherin_repeat 1523..1628 CDD:206637 21/141 (15%)
celsr1bXP_001920772.2 Cadherin_repeat 244..343 CDD:206637 37/114 (32%)
Cadherin_repeat 351..451 CDD:206637 28/117 (24%)
Cadherin_repeat 460..557 CDD:206637 34/96 (35%)
Cadherin_repeat 565..662 CDD:206637 25/103 (24%)
COG1361 647..1132 CDD:224280 162/684 (24%)
Cadherin_repeat 671..764 CDD:206637 31/100 (31%)
Cadherin_repeat 773..867 CDD:206637 35/231 (15%)
Cadherin_repeat 875..973 CDD:206637 33/110 (30%)
Cadherin_repeat 981..1075 CDD:206637 27/103 (26%)
Cadherin_repeat 1098..1176 CDD:206637 22/103 (21%)
EGF_CA 1342..1377 CDD:238011 6/48 (13%)
EGF_CA 1387..1419 CDD:214542 6/31 (19%)
LamG 1422..1605 CDD:238058 13/61 (21%)
EGF_CA 1629..1663 CDD:238011
Laminin_G_2 1697..1827 CDD:280389
EGF_CA 1852..1886 CDD:238011
EGF 1889..1922 CDD:278437
Laminin_EGF <1912..1946 CDD:278482
Laminin_EGF 1944..>1978 CDD:278482
EGF_Lam 1980..>2018 CDD:238012
HormR 2030..2091 CDD:214468
GAIN 2109..2357 CDD:293098
GPS 2387..2432 CDD:280071
7tm_2 2444..2674 CDD:278432
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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