DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad74A and CDHR2

DIOPT Version :10

Sequence 1:NP_648973.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:NP_060145.3 Gene:CDHR2 / 54825 HGNCID:18231 Length:1310 Species:Homo sapiens


Alignment Length:1683 Identity:398/1683 - (23%)
Similarity:608/1683 - (36%) Gaps:519/1683 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MLPLLLPLFL--SLTAGQLVNQPPQFVPGTGDMSRFSLSENTPVGSPVFQLKGTDPEGGRLKYSI 63
            |..|.|..||  :|......|..|:|:   .:|:...|.|:.|||:..|.|...|.:...|.|.:
Human     1 MAQLWLSCFLLPALVVSVAANVAPKFL---ANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGM 62

  Fly    64 SGP---VFSVDRETGVVRLRQELDRETQDTVEVIISITDEGIYGTEPNTVSQRRVIPVRDYNDNQ 125
            |||   .|:|..:||.|:|...||.||..|.:|.||::|..|      .|.:..::.|.|.|||.
Human    63 SGPNAYFFAVTPKTGEVKLASALDYETLYTFKVTISVSDPYI------QVQREMLVIVEDRNDNA 121

  Fly   126 PTFLGRPYTASVSESLPVGSELSVEPPIVVVDRDEGINSEVQMKCLEENDICDIFEVRAVKISDG 190
            |.|....::.|::|:||||   ||...::.||:|.|....|            ::.:..|..|.|
Human   122 PVFQNTAFSTSINETLPVG---SVVFSVLAVDKDMGSAGMV------------VYSIEKVIPSTG 171

  Fly   191 N--------YTARVALKQQLDFESRPS-YILTISASD------SALDNRLSSLATISINVIDIQD 240
            :        ....:.|...|.:.::.: |.|.:.|.|      :....:.|....:||:|:|..|
Human   172 DSEHLFRILANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPD 236

  Fly   241 QPPIFTNAPYSATVPENTPAGVSILTVKAVDGDVGI--PREIFLSLEDEPFGHFELVPFGDPRDG 303
            ..|.|....|||:|.|:...|.|:|||:|||||.||  |....:|....| |.|::     ..||
Human   237 LDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRP-GWFDI-----GADG 295

  Fly   304 TAVLQTTSEPLDRENAEILQNGGVYVFSIRATELIDGAIPAEHSLT-RVTIVVTDVDDHQP---- 363
              |::.... ||||  ::|:........:.|||........|..:: .||:.|.||:||:|    
Human   296 --VIRVNGS-LDRE--QLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYN 355

  Fly   364 ------TFSGPHFNVSIT----ENLANGMPLPGLSIFVDDRDMGENSRYELSLRDVFNAARVFEV 418
                  ||:.....|:.|    |:.:..:|:..|::.|.|.|.|.|..:.|||..  ..|..|.|
Human   356 CSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGG--PDAEAFSV 418

  Fly   419 SPTESQGRTPVVVKVLNASRLDYD--------VVDPDLRKFEFDLVASVKGVEKAKTRVEIHLLD 475
            ||..:.|...|.|.|..::.:||:        ||..|.....|.:           ..|.|||.|
Human   419 SPERAVGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSV-----------AMVTIHLRD 472

  Fly   476 ANDNAPVFDQGTYRFTAAENLPVDAII-GHVKATDLDSGEFGHVRY-VLKGFGADNFYVNPETGG 538
            .||:.|.|.|..|..|..|:....::: ..:.|||.|:|.:|.:.| :|.|.|||.|.|:|.:|.
Human   473 INDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGT 537

  Fly   539 VYLL--KPLDYEKQSSYSLTVVAIDGGQREANANLFVGVTDVNDNHPNFESKEYSRTIREGAALF 601
            |.:.  :.||.|.|:.|.||:.|.|||...::..|.:.:.|:|||.| ..|..|:..::|...  
Human   538 VTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAP-VVSGSYNIFVQEEEG-- 599

  Fly   602 EPQFFVRAHDADGPSQGNGRVKYSIV----SENSIAGNVFRIEPDTGEIVIQKAARSMDTERGEY 662
            .....::|||.|.|...|.|:.::::    |.|      |.::||||                  
Human   600 NVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHN------FSLDPDTG------------------ 640

  Fly   663 ELVVSATDFGIPPLSNTTRVLVRVGISGNQRPIFRGHFQNMENLPIIGPPSYRVSIPENAAAGSN 727
                                |:|     |..|:                                
Human   641 --------------------LLR-----NLGPL-------------------------------- 648

  Fly   728 VTSVSAHDPDGLDSLLRYRIVGANDNFEIDEISGLITVSPQARIDRDSNMNSFEIIVNAVDSGTP 792
                   |.:.:|..|..|||                                 :.|...|.|.|
Human   649 -------DREAIDPALEGRIV---------------------------------LTVLVSDCGEP 673

  Fly   793 IPETATTTVYVNVKDINDERPKFEQNSYATYVSERTAVGESVLRVKAIDKD---LNSKLEYSMVG 854
            :..| ...|.:.|:||||..|.|.|:||...|.|... |..|..|||.|.|   .|:::.:|:.|
Human   674 VLGT-KVNVTITVEDINDNLPIFNQSSYNFTVKEEDP-GVLVGVVKAWDADQTEANNRISFSLSG 736

  Fly   855 PVAATTKAGVSIANRSNYRLQEAFRVDSQSGEIFVNGTLRHDVAAIIIFTVGVRDLNAEVDPEGQ 919
                         :.:||.:                      :..:::                 
Human   737 -------------SGANYFM----------------------IRGLVL----------------- 749

  Fly   920 VDTTEVTVYVQSFQDTNPVFKNTGWTSSRPVIDVKIKEEMPIDSALFILQAEDPVTRQPITSFEL 984
                                 ..||                         ||..:...|..|   
Human   750 ---------------------GAGW-------------------------AEGYLRLPPDVS--- 765

  Fly   985 IEPKQVDYFQVAERTGEVILKKRLDYEALGDTGPEFELQVRANSADRQ-RSTVSRVNITVENVND 1048
                                   ||||    |.|.|.|.|.|.:.|.| ..|:..|.:.|::|||
Human   766 -----------------------LDYE----TQPVFNLTVSAENPDPQGGETIVDVCVNVKDVND 803

  Fly  1049 NSPRFERNSYQA-TIIENRPHPERVIRVRALDKDAVLNARDERLGYHKIIYSLQGEHAMLFDINN 1112
            |.|..:..|.:. .:.||.....:|..|.|.|.|.......:.:   .|:.:..|     .|:.:
Human   804 NPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLV---NILCTKAG-----VDVGS 860

  Fly  1113 ---------TTGEIIVASGQTIDRERTPRIQLQIKAED---SPGRPTDAKQSVVELQIEVLDVND 1165
                     ..|.:.:...:.||.|....:.|.::|.|   .||  ..|..:...|.|.:.||||
Human   861 LCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPG--FQAYSNNGSLLITIEDVND 923

  Fly  1166 NAPEF-TQKKYSTVIPENAQIDSFVLQLEAVDADEGLGGEV-----RYELVNEGEA----NGLFK 1220
            |||.| .:.|...:|||....:..|..:.|.|.|.|..|.:     |.:.:::..|    .|:|.
Human   924 NAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFS 988

  Fly  1221 IDTKS------GLIS--TRRNLTGKGRAHPYVLIVRAQDNGNQMPKQPTLSTDTDVRIYIGDVSA 1277
            |.|.|      |.|.  |..:.|.:|   .|.:.|:|:|..:   ..|.|...|.:.::..|.|.
Human   989 IFTSSEADVFAGSIQPVTSLDSTLQG---TYQVTVQARDRPS---LGPFLEATTTLNLFTVDQSY 1047

  Fly  1278 NDGVPYFLSPR--VG---QMANVTENAVTGAPVFQVIASDPDDESTPSGTITYRILPDT------ 1331
            ...: .|.:|:  ||   |..|......|...|:.|...|.|..:        |..|.:      
Human  1048 RSRL-QFSTPKEEVGANRQAINAALTQATRTTVYIVDIQDIDSAA--------RARPHSYLDAYF 1103

  Fly  1332 --PDAEAFVIDAHSGLITTRQSMDRETKDMYRILLEVSDNGQPKQSATRILQIAILDVDDHEPRF 1394
              |:..|..:|..|.:|...|                       .|.|::||:.::.:...|   
Human  1104 VFPNGSALTLDELSVMIRNDQ-----------------------DSLTQLLQLGLVVLGSQE--- 1142

  Fly  1395 AREADAGPLSMSVREEEPAGTIVGNFSALDEDLGENAAIDYVIIDGNNEQLFTIERN--NESLAI 1457
            ::|:|.....:||        |:|        ||....:..||:    ...|...|.  |..|..
Human  1143 SQESDLSKQLISV--------IIG--------LGVALLLVLVIM----TMAFVCVRKSYNRKLQA 1187

  Fly  1458 LKTKKPIDREQV---------------------ESFTLTIKCLKLGEPGYKFIGDPYDRQDLSHL 1501
            :|..|...:...                     ....|..|.|     |.:::....|...:|..
Human  1188 MKAAKEARKTAAGVMPSAPAIPGTNMYNTERANPMLNLPNKDL-----GLEYLSPSNDLDSVSVN 1247

  Fly  1502 RINVRVLDIDDNLPKFE---------QPDPTVGIRINVPIDTVVTTLKA-SDADAEAP 1549
            .::...:|:|.|..:.:         :|||.       |:..|:...:| :....|.|
Human  1248 SLDDNSVDVDKNSQEIKEHRPPHTPPEPDPE-------PLSVVLLGRQAGASGQLEGP 1298

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_648973.1 Cadherin_repeat 33..124 CDD:206637 33/93 (35%)
Cadherin_repeat 132..240 CDD:206637 27/122 (22%)
Cadherin_repeat 249..361 CDD:206637 39/114 (34%)
Cadherin_repeat 487..581 CDD:206637 34/97 (35%)
Cadherin_repeat 589..686 CDD:206637 17/100 (17%)
Cadherin_repeat 713..810 CDD:206637 15/96 (16%)
Cadherin_repeat 819..936 CDD:206637 16/119 (13%)
Cadherin_repeat 953..1049 CDD:206637 21/96 (22%)
Cadherin_repeat 1057..1166 CDD:206637 26/121 (21%)
Cadherin_repeat 1175..1279 CDD:206637 30/120 (25%)
Cadherin_repeat 1293..1390 CDD:206637 18/104 (17%)
Cadherin_repeat 1402..1513 CDD:206637 22/133 (17%)
Cadherin_repeat 1523..1628 CDD:206637 5/28 (18%)
CDHR2NP_060145.3 Cadherin_repeat 32..120 CDD:206637 33/93 (35%)
Cadherin_repeat 129..236 CDD:206637 27/121 (22%)
Cadherin_repeat 246..349 CDD:206637 39/113 (35%)
Cadherin_repeat 372..476 CDD:206637 33/116 (28%)
Cadherin_repeat 485..582 CDD:206637 34/96 (35%)
Cadherin_repeat 589..691 CDD:206637 36/225 (16%)
Cadherin_repeat 699..804 CDD:206637 39/233 (17%)
CA <864..926 CDD:214520 17/63 (27%)
Cadherin_repeat 935..1044 CDD:206637 28/114 (25%)
Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organization. /evidence=ECO:0000269|PubMed:24725409 1180..1310 21/131 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1259..1310 9/47 (19%)

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