DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad74A and DCHS2

DIOPT Version :10

Sequence 1:NP_648973.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:NP_001345164.1 Gene:DCHS2 / 54798 HGNCID:23111 Length:3371 Species:Homo sapiens


Alignment Length:2707 Identity:574/2707 - (21%)
Similarity:901/2707 - (33%) Gaps:1099/2707 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 PLLLPLFLSLTAGQLVNQPPQFVPGTGDMSRFSLSENTPVGSPVFQLKGTD-PEGGR----LKYS 62
            ||.....|.|....|.:|||.|   :....:.|:||....|:.|..:..:| .|.|.    |:|:
Human   518 PLSTEETLLLRVADLNDQPPLF---SQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYT 579

  Fly    63 I---------------------SGPVFSVDRETGVVRLRQELDRETQDTVEVIISITDEGIYGTE 106
            :                     .||.|::|.|:|.:...:.||||.|:.||:.:...|   .|..
Human   580 VVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQD---LGEP 641

  Fly   107 PNTVSQRRVIPVRDYNDNQPTFLGRPYTASVSESLPVGSELSVEPPIVVVDRDEGINSEVQMKCL 171
            |.:.:....|.|.|.|||:|.|..:.|.|:::|..|||....   .:...|.|.|:...:     
Human   642 PLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFL---QVTASDADSGLYGFI----- 698

  Fly   172 EENDICDIF----EVRAVKIS--DGNYTARVALKQQLDFESRP-SYILTISASDSALDNRLSSLA 229
             |..:.|.|    ..:|.:|.  ||    ::.:.|.:|.|..| :|.|.:.|.|.   ..||:.|
Human   699 -EYSLYDGFLSYEAPQAFRIDPHDG----QICVSQDIDRERDPATYDLLVEAKDG---GGLSAQA 755

  Fly   230 TISINVIDIQDQPPIFTNAPYSATVPENTPAGVSILTVKAVDGDVGI------------------ 276
            .:.:::.|:.|..|:|..:.|..::.:.|..|..|:.|.|.|.|.||                  
Human   756 FVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFT 820

  Fly   277 ----------------------------------------------------------PREIFLS 283
                                                                      |:..||.
Human   821 IDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLV 885

  Fly   284 LED-------------EPFGH----FELVPFGD--------PRDGTAVLQTTSEPLDRENAEILQ 323
            .||             ||...    |..:..||        ||.||.   .|.:|||.|...:: 
Human   886 YEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTI---RTRKPLDHETQPVV- 946

  Fly   324 NGGVYVFSIRATELIDGAIPAEHSLTRVTIVVTDVDDHQPTFSGPHFNVSITENLANGMPLPGLS 388
                 |.:::| :|  |:.|| .|.|.|.|.|.||:|:.|.|......:.|::...     ||.:
Human   947 -----VLTVQA-QL--GSAPA-CSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTP-----PGTA 997

  Fly   389 IFV---DDRDMGENS--RYELS-----------------LRDVFNAARVFEVSPT---ESQGRTP 428
            :::   :|||.|.|.  ||.::                 |.....|....|::.|   |.||..|
Human   998 LYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHP 1062

  Fly   429 -----VVVKVLN------------------------------------------ASRLDYDV--- 443
                 |:..|:.                                          ||.|.|.:   
Human  1063 QAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPS 1127

  Fly   444 VDPDL-------------RKFEFDLVASVK-----------GVEKAKTRVEIHLLDANDNAPVFD 484
            ||..:             |:|:::...:..           .::...|.|.:.:.|.|||:|.|.
Human  1128 VDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFL 1192

  Fly   485 QGTYRFTAAENLPV-DAIIGHVKATDLDSGEFGHVRYVLKGFGADNFYVNPETGGVYLLKPLDYE 548
            .... |...|..|| ..:||.:.|.|:|||:.|.:.|.|...| ..|.:||.||.:.....||.|
Human  1193 HDVL-FLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG-KFFKMNPNTGELINWVALDRE 1255

  Fly   549 KQSSYSLTVVAIDGGQREANANL--FVGVTDVNDNHPNF----ESKEYSRTIREGAALFEPQFFV 607
            .:..:.:||:..|.|....||.:  :|.|||:|||.|.|    ..||....:.||..:   ...|
Human  1256 HRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPV---NMLV 1317

  Fly   608 RAHDADGPSQG-NGRVKYSIVSENSIAGNVFRIEPDTGEIVIQKAARSMDTE-RGEYELVVSATD 670
            ....|..|.:| |..|.||:.||:|  .:.|:|:.:.|||   :....:..: |..|.:.|.|||
Human  1318 TTVFAKDPDEGNNAEVTYSVSSEDS--SDHFKIDANNGEI---RTTTILSYDYRPSYRMSVIATD 1377

  Fly   671 FGIPPLSNTTRVLVRV-----G------------ISGNQRP------------------------ 694
            .|:|||.....|.::|     |            |..|.:|                        
Human  1378 QGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFS 1442

  Fly   695 ---------------------------------IFR----GHFQNM------------------- 703
                                             :||    .|.:|:                   
Human  1443 IVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHS 1507

  Fly   704 -------------ENLPI-------------------------------IGP----PSY------ 714
                         ||:||                               ..|    ||:      
Human  1508 PSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTV 1572

  Fly   715 ----RVSIP------------------------------------------------ENAAAGSN 727
                |.|||                                                |:...||.
Human  1573 SRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPNAHVKEDVTVGSL 1637

  Fly   728 VTSVSAHDPD-GLDSLLRYRIVGANDN--FEIDEISGLITVSPQARIDRDSNMNSFEII-VNAVD 788
            |..::||||| |.:..:.|.|:..|:|  |.:||.|||:|.:    ...|..|.:..|: |.|:|
Human  1638 VHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTT----CPLDYEMKTQHILTVLALD 1698

  Fly   789 SGTPIPETATTTVYVNVKDINDERPKFEQNSYATYVSERTAVGESVLRVKAIDKD--LNSKLEYS 851
            .||| ..:::.|:.|.|.|:|||.|.|:|:.|...|.|....||.|.||:|:|:|  :||||::.
Human  1699 DGTP-ALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFE 1762

  Fly   852 MVGPVAATTKAGVSIANRSNYRLQEAFRVDSQSGEIFVNGTLRHDVAAIIIFTVGVRD-----LN 911
            ::        .|.|.         |.|.::|.:||:.....|..::..:....|.|||     |:
Human  1763 IM--------PGASF---------ELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLS 1810

  Fly   912 AEVDPEGQVDTTEVTVYVQSFQDTNPVFKNTGWTSSRPVIDVKIKEEMPIDSALFILQAEDPVTR 976
            :         ||.:...|:...|..|.|..:.:       |:::.|....:....:|.::.....
Human  1811 S---------TTTILCTVEDENDHAPEFIVSSY-------DIEVLENQEPEVVYTVLASDMDAGN 1859

  Fly   977 QPITSFELIEPKQVDYFQVAERTGEVILKKRLDYEALGDTGPEFELQVRANS-ADRQRSTVSRVN 1040
            .....:.:|:....:.|.:.|.:||:...:.||.|.:.:    |.|.:..:. .|..||:|..:.
Human  1860 NRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISN----FTLVILCSDLGDPPRSSVIHLQ 1920

  Fly  1041 ITVENVNDNSPRFERNSYQATIIENRPHPERVIRVRALDKDAVLNAR------DERLGYHKI--- 1096
            :.|.:.||:||.|....||:::.|:......|:.:.|:|||..||.:      ||..|...|   
Human  1921 VRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPM 1985

  Fly  1097 -------------------------IYSLQGEHAML---------------------FDI----- 1110
                                     ..|:||..:..                     ||:     
Human  1986 SGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPE 2050

  Fly  1111 ---NNTT-------------GEIIVASGQT-----IDR-------ERTPR-----IQLQIKAEDS 1142
               |.||             |.::.:..:|     ||:       ::.|.     |.||:|..|.
Human  2051 SPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQ 2115

  Fly  1143 --PGRPT------------------------------DAKQSVV--------------------- 1154
              |.|.|                              :|..|:|                     
Human  2116 GIPARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSG 2180

  Fly  1155 -----------------------------ELQIEVL-----------------DVNDNAPEFTQK 1173
                                         |:|:.||                 |.|||:|.|.|.
Human  2181 NEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVAVLIQDENDNSPCFEQS 2245

  Fly  1174 KYSTVIPENAQIDSFVLQLEAVDADEGLGGEVRYELV--NEGEANGLFKIDTKSGLISTRR---- 1232
            .|...:.|:...::.|:|:.|.|.|.||.|.:.|.::  |:.||   |:||..||:|:|:.    
Human  2246 IYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEA---FQIDALSGVITTKAILDY 2307

  Fly  1233 NLTGKGRAHPYVLIVRAQDNGNQMPKQPTLSTDTDVRIYIGDVSANDGVPYFLSPRVGQMANVTE 1297
            .||..     |.|||:|.|.|     .|.||..|.:::.:.|:  ||..|.||.   .:...:||
Human  2308 ELTSS-----YSLIVQATDKG-----MPRLSNTTVIKVQVTDI--NDNAPAFLP---SEAVEITE 2357

  Fly  1298 NAVTGAPVFQVIASDPD------------------------------------------------ 1314
            :::.|..|..|...|.|                                                
Human  2358 DSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQI 2422

  Fly  1315 ----------------------------------DESTPSG---------------TITYRILP- 1329
                                              .||.|.|               .|:||||. 
Human  2423 SDSVHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSS 2487

  Fly  1330 ----------------------DTPDAEAFVIDAHSG---------------------------- 1344
                                  ||.....|:::|..|                            
Human  2488 SKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVK 2552

  Fly  1345 ---------------LIT--------TRQ------------------------------------ 1350
                           |:|        ||:                                    
Human  2553 SYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYL 2617

  Fly  1351 ----SMDRETKDMYRILLEVSDNGQPKQSATRILQIAILDVDDHEPRFAREADAGPLSMS----V 1407
                |:|||....:.:::..||:|.|..|:|.::.|.:|||:|:.|.|:        |:|    |
Human  2618 VLLHSLDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFS--------SLSYHTHV 2674

  Fly  1408 REEEPAGTIVGNFSALDEDLGENAAIDYVIIDGNNEQLFTIERNNESLAILKTKKPIDREQVESF 1472
            :|..|.|:.:...||.|.|.|.:|.|.|.||.||.:..|.:|.|...|.::   ||:|.|::..|
Human  2675 KESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLI---KPLDYEKMTKF 2736

  Fly  1473 TLTIKCLKLGEPGYKFIGDPYDRQDLSHLRINVRVLDIDDNLPKFEQPDPTVGIRINVPIDTVVT 1537
            |||::            ....:::..|...:.|.|||.:|:.|:|.....:..:..|:||.:.:.
Human  2737 TLTVQ------------ASDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTIC 2789

  Fly  1538 TLKASDADAEAPPVG-LSIENVTFVPQFYKRSRSLAVGNLHNLFTLNNRTGELRTGGSFADYVDG 1601
            ::.|.|.|  |.|.| |:...|:  |.|.....|..    |:||.::..||::. .....||.:|
Human  2790 SINALDFD--AGPYGELTYSIVS--PCFLTHGMSYD----HDLFLIDPLTGDIH-AKQILDYENG 2845

  Fly  1602 -YFLMRVMANNSVQPKRQAHSNLKVFVIRDKSLLKFVFARPPNEIQHNIRPFQEQLQKKLKPLGL 1665
             .:.:.|.|.:    |..|.::|.|:|                    :|....|     .:|:..
Human  2846 NKYCLTVQAKD----KGDATASLVVWV--------------------DIEGIDE-----FEPIFT 2881

  Fly  1666 ELHVLDTQVFTRPDMSLD-----------------------FTATSSCFQMFKNGAALSFNEMQK 1707
            :    |...||.|:.:.|                       ...:|..|.:.|....:.......
Human  2882 Q----DQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSLGTSSPFFSVNKTNGNIYLIRALP 2942

  Fly  1708 LMNSQQLRQELIDI----YAAYGVSEVESCSVRRTHAAAIFAGM-LTSAGAWLVFLAALIGLAAL 1767
            |:.||..:::.:::    ::....|:..||:|        |..: .:|.|..|...|:...::.:
Human  2943 LIKSQLNKEDTLEMKIIAHSPKSDSKFASCTV--------FVNVSFSSEGTPLAVFASSFSISLV 2999

  Fly  1768 VS----LCTACCLKKKLKRHSKR------------SLQASLR 1793
            ||    |...|.|...:.||.::            ||.|.||
Human  3000 VSFLVFLILICILIVMILRHKQKDTINNYEEKKTSSLDADLR 3041

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_648973.1 Cadherin_repeat 33..124 CDD:206637 30/116 (26%)
Cadherin_repeat 132..240 CDD:206637 28/114 (25%)
Cadherin_repeat 249..361 CDD:206637 42/212 (20%)
Cadherin_repeat 487..581 CDD:206637 34/96 (35%)
Cadherin_repeat 589..686 CDD:206637 30/98 (31%)
Cadherin_repeat 713..810 CDD:206637 39/158 (25%)
Cadherin_repeat 819..936 CDD:206637 32/123 (26%)
Cadherin_repeat 953..1049 CDD:206637 18/96 (19%)
Cadherin_repeat 1057..1166 CDD:206637 44/300 (15%)
Cadherin_repeat 1175..1279 CDD:206637 35/109 (32%)
Cadherin_repeat 1293..1390 CDD:206637 39/307 (13%)
Cadherin_repeat 1402..1513 CDD:206637 35/114 (31%)
Cadherin_repeat 1523..1628 CDD:206637 28/106 (26%)
DCHS2NP_001345164.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40
Cadherin_repeat 70..163 CDD:206637
Cadherin_repeat 176..292 CDD:206637
Cadherin_repeat 300..409 CDD:206637
Cadherin_repeat 423..534 CDD:206637 5/15 (33%)
Cadherin_repeat 543..659 CDD:206637 30/118 (25%)
Cadherin_repeat 667..767 CDD:206637 28/115 (24%)
Cadherin_repeat 775..866 CDD:206637 10/90 (11%)
Cadherin_repeat 881..975 CDD:206637 31/106 (29%)
Cadherin_repeat 985..1074 CDD:206637 20/93 (22%)
Cadherin_repeat 1088..1187 CDD:206637 12/98 (12%)
Cadherin_repeat 1195..1290 CDD:206637 34/96 (35%)
Cadherin_repeat 1302..1394 CDD:206637 30/99 (30%)
Cadherin_repeat 1412..1506 CDD:206637 7/93 (8%)
Cadherin_repeat 1515..1616 CDD:206637 11/100 (11%)
Cadherin_repeat 1625..1719 CDD:206637 34/98 (35%)
Cadherin_repeat 1729..1825 CDD:206637 31/121 (26%)
Cadherin_repeat 1833..1929 CDD:206637 19/106 (18%)
Cadherin_repeat 1938..2034 CDD:206637 17/95 (18%)
Cadherin_repeat 2042..2129 CDD:206637 18/86 (21%)
CA 2162..2240 CDD:214520 8/77 (10%)
Cadherin_repeat 2246..2343 CDD:206637 36/111 (32%)
Cadherin_repeat 2353..2443 CDD:206637 7/89 (8%)
Cadherin_repeat 2452..2543 CDD:206637 14/90 (16%)
Cadherin_repeat 2553..2661 CDD:206637 18/107 (17%)
Cadherin_repeat 2669..2765 CDD:206637 34/110 (31%)
Cadherin_repeat 2778..2868 CDD:206637 28/102 (27%)
Cadherin_repeat 2884..2978 CDD:206637 15/101 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3117..3141
Blue background indicates that the domain is not in the aligned region.

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