DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad74A and Celsr2

DIOPT Version :10

Sequence 1:NP_648973.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:NP_059088.2 Gene:Celsr2 / 53883 MGIID:1858235 Length:2919 Species:Mus musculus


Alignment Length:1930 Identity:434/1930 - (22%)
Similarity:725/1930 - (37%) Gaps:579/1930 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MLPLLLPLFLSLTAGQLVNQPPQFVPGTGDMSRFSLSENTPVGSPVFQLKGTDPEGGRLKYSISG 65
            :|||||.|.|         .||.  |..||    .:.....:||           |||.......
Mouse    14 LLPLLLLLLL---------LPPS--PLLGD----QVGPCRSLGS-----------GGRSSSGACA 52

  Fly    66 PV--------------FSVDRETGVVRLRQELDRETQDTVEVIISIT------DEGIYGTEPNTV 110
            ||              .|..||:|                   |.:|      .:|:....|.:.
Mouse    53 PVGWLCPASASNLWLYTSRCRESG-------------------IELTGHLVPHHDGLRVWCPESG 98

  Fly   111 SQRRVIPVRDYNDNQPTFLGRPYTASVSESLPVGSELSVEPPIVVVDRDEGINSEVQMKCLEEND 175
            :.   ||:      .|:..|.|::..:   |.:|..||.:..:.:.:....:.:. :::|    .
Mouse    99 AH---IPL------PPSSEGCPWSCRL---LGIGGHLSPQGTLTLPEEHPCLKAP-RLRC----Q 146

  Fly   176 ICDIFEVRAVKISDGNYTARVALKQQLDFESRPSYILTISASDSALDNRLSSLATISINVIDIQD 240
            .|.:.:...::..:|:....:..:::.:..:.|.:                              
Mouse   147 SCKLAQAPGLRAGEGSPEESLGGRRKRNVNTAPQF------------------------------ 181

  Fly   241 QPPIFTNAPYSATVPENTPAGVSILTVKAVDGDVGIPREIFLSLE---DEPFGHFELVPFGDPRD 302
            |||     .|.||||||.|||.|:.:::|:|.|.|....:..:::   |....||..:   ||..
Mouse   182 QPP-----SYQATVPENQPAGTSVASLRAIDPDEGEAGRLEYTMDALFDSRSNHFFSL---DPIT 238

  Fly   303 GTAVLQTTSEPLDRENAEILQNGGVYVFSIRATELIDGAIPAEHSLTRVTIVVTDVDDHQPTFSG 367
            |..   ||:|.||||..      ..:||.:.|.   |..:|...:|..:||:|||.:||.|.|..
Mouse   239 GVV---TTAEELDRETK------STHVFRVTAQ---DHGMPRRSALATLTILVTDTNDHDPVFEQ 291

  Fly   368 PHFNVSITENLANGMPLPGLSIFVDDRDMGENSRYELSLRDVFNAARVFEVSPTESQGRTPVVVK 432
            ..:..|:.|||..|                                                   
Mouse   292 QEYKESLRENLEVG--------------------------------------------------- 305

  Fly   433 VLNASRLDYDVVDPDLRKFEFDLVASVKGVEKAKTRVEIHLLDANDNAPVFDQGTYRFTAAENLP 497
                    |:|:.                                                    
Mouse   306 --------YEVLT---------------------------------------------------- 310

  Fly   498 VDAIIGHVKATDLDSGEFGHVRY-VLKGFG---ADNFYVNPETGGVYLLKPLDYEKQSSYSLTVV 558
                   |:|||.|:....::.| :|:|.|   :|.|.::|.:|.:....|:|.|:..||.|||.
Mouse   311 -------VRATDGDAPPNANILYRLLEGAGGSPSDAFEIDPRSGVIRTRGPVDREEVESYKLTVE 368

  Fly   559 AIDGGQ----REANANLFVGVTDVNDNHPNFESKEYSRTIREGAALFEPQFFVRAHDADGPSQGN 619
            |.|.|:    |.:.|.:|:.|.|.|||.|.|..|.|...:||......|...|.|.|.|..|  |
Mouse   369 ASDQGRDPGPRSSTAIVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGS--N 431

  Fly   620 GRVKYSIVSENSIAGNVFRIEPDTGEIVIQKAARSMDTE-RGEYELVVSATDFGIPPLSNTTRVL 683
            ..|.|||:|.|  |...|.::..||.:.:   ...:|.| ..||.|.:.|.|.|.|||||.:.::
Mouse   432 ALVHYSIMSGN--ARGQFYLDAQTGALDV---VSPLDYETTKEYTLRIRAQDGGRPPLSNVSGLV 491

  Fly   684 VRVGISGNQRPIFRGHFQNMENLPIIGPPSYRVSIPENAAAGSNVTSVSAHDPD-GLDSLLRYRI 747
            ....:..|            :|.||.....::.::.|:...|..|..|.|.|.| |.::.|.|.:
Mouse   492 TVQVLDIN------------DNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYSL 544

  Fly   748 VGANDNFEIDEISGLITVSPQARIDRDSNMNSFEIIVNAVDSGTPIPETATTTVYVNVKDINDER 812
            .|...:|.....:|...:|..|.:||: .::.:...|.|.|.||| ..||:.:|.|.:.|:||..
Mouse   545 AGVGHDFPFTINNGTGWISVAAELDRE-EVDFYSFGVEARDHGTP-ALTASASVSVTILDVNDNN 607

  Fly   813 PKFEQNSYATYVSERTAVGESVLRVKAIDKDLNSKLEYSMV-----GPVAATTKAG---VSIANR 869
            |.|.|..|...::|..|||.||:.|.|:|:|.:|.:.|.:.     ...:.|:::|   ||:|..
Mouse   608 PTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALP 672

  Fly   870 SNYRLQEAFRVDSQSGEIFVNGTLRHDVAAIIIFTVGVRDLNAEVDPEGQVDTTEVTVYVQSFQD 934
            .:|:|:..:.:...:.:    || |.|.|.|:   |.|.|.|..                     
Mouse   673 LDYKLERQYVLAVTASD----GT-RQDTAQIV---VNVTDANTH--------------------- 708

  Fly   935 TNPVFKNTGWTSSRPVIDVKIKEEMPIDSALFILQAEDPVTRQ--PITSFELIEPKQVDYFQVAE 997
             .|||:::.:|       |.:.|:.|..:.:.::.|.|..|.:  .||.|   ....:..|::..
Mouse   709 -RPVFQSSHYT-------VNVNEDRPAGTTVVLISATDEDTGENARITYF---MEDSIPQFRIDA 762

  Fly   998 RTGEVILKKRLDYEALGDTGPEFELQVRA-NSADRQRSTVSRVNITVENVNDNSPRFERNSYQAT 1061
            .||.|..:..||||    ....:.|.:.| ::...|:|..:.:.|.|.:||||:|:|.|:|||.:
Mouse   763 DTGAVTTQAELDYE----DQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGS 823

  Fly  1062 IIENRPHPERVIRVRALDKDAVLNARDERLGYHKIIYSLQG--EHAMLFDINNTTGEIIVASGQT 1124
            :.|:.|....|:::.|.|:|:.||.|        :.|:.||  :....|.:.:|:|  ||.:.:.
Mouse   824 VYEDVPPFTSVLQISATDRDSGLNGR--------VFYTFQGGDDGDGDFIVESTSG--IVRTLRR 878

  Fly  1125 IDRERTPRIQLQIKAEDSPGRPTDAKQSVVELQIEVLDVNDNAPEFTQKKYSTVIPENAQIDSFV 1189
            :|||...:..|:..|.|. |.|  ..::.:|:.:.|||||||.|.|.|.::...:.||:.|...|
Mouse   879 LDRENVAQYVLRAYAVDK-GMP--PARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAV 940

  Fly  1190 LQLEAVDADEGLGGEVRYELVNEGEANGLFKIDTKSGLISTRRNLTGKGRAHPYVLIVRAQDNGN 1254
            .::.|.|.|||...::.|::| ||....:|::|..||.::...:|..:.|.. |||:::|     
Mouse   941 ARVTATDPDEGTNAQIMYQIV-EGNIPEVFQLDIFSGELTALVDLDYEDRPE-YVLVIQA----- 998

  Fly  1255 QMPKQPTLSTDTDVRIYIGDVSANDGVPYFLSPRVGQMANVTENAVT-------GAPVFQVIASD 1312
              ...|.:|..|   :::..:..||..|.     :|....:..|.||       |..:.:|.|.|
Mouse   999 --TSAPLVSRAT---VHVRLLDRNDNPPV-----LGNFEILFNNYVTNRSSSFPGGAIGRVPAHD 1053

  Fly  1313 PDDESTPSGTITYRILPDTPDAEAFVIDAHSGLITTRQSMDRETKDMYRILLEVSDNGQPKQSAT 1377
            ||    .|.::||...... :....:::|.:|.:...:::| ..:.:..|:..:..:|....:|.
Mouse  1054 PD----ISDSLTYSFERGN-ELSLVLLNASTGELRLSRALD-NNRPLEAIMSVLVSDGVHSVTAQ 1112

  Fly  1378 RILQIAI-----------LDVDDHEPRFAREADAGPLSMSVREEEPAGTIVGNFSALDEDLGENA 1431
            ..|::.|           |.::|..|    |....|| :.:..:..|.|:.             .
Mouse  1113 CSLRVTIITDEMLTHSITLRLEDMSP----ERFLSPL-LGLFIQAVAATLA-------------T 1159

  Fly  1432 AIDYVIIDGNNEQLFTIERNNESLAILKTKKPIDREQVESFTLTIKCLKLGEPGYKFIGDPY--- 1493
            ..|:|::       |.::|              |.:......|.:. |.:|:|.....|.|:   
Mouse  1160 PPDHVVV-------FNVQR--------------DTDAPGGHILNVS-LSVGQPPGPGGGPPFLPS 1202

  Fly  1494 -DRQDLSHLRINV-------RVLDIDDNLPKFEQPDPTVGIRINVPIDTVVTTLKASDADAEAPP 1550
             |.|:..:|..::       |||..|||            |.:..|.:..:..:.....|:.||.
Mouse  1203 EDLQERLYLNRSLLTAISAQRVLPFDDN------------ICLREPCENYMRCVSVLRFDSSAPF 1255

  Fly  1551 VGLSIENVTFVPQF--------------------------------YKRSRSLAVGNLHNLFTLN 1583
            :..|  :|.|.|..                                :.|.||...|  :....|:
Mouse  1256 IASS--SVLFRPIHPVGGLRCRCPPGFTGDYCETEVDLCYSRPCGPHGRCRSREGG--YTCLCLD 1316

  Fly  1584 NRTGE---------------LRTGGSFADYVDGYFLMRVMANNSVQP------------------ 1615
            ..|||               .:.||:..:.:.|.|.....:.:..:|                  
Mouse  1317 GYTGEHCEASTHSGRCTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPFCQVTTRSFPARSFITFR 1381

  Fly  1616 --KRQAHSNLKV-FVIRDKSLLKFVFARPPNEIQHN---IRPFQEQLQ------------KKLKP 1662
              :::.|..|.: |..::::.|.....| .|| :|:   :...|||:|            ....|
Mouse  1382 GLRQRFHFTLALSFATKERNGLLLYNGR-FNE-KHDFVALEVIQEQVQLTFSAGESTTTVSPFVP 1444

  Fly  1663 LGL---ELHVLDTQVFTRP------------DMSLDFTATSSCFQMFKNGAALSFNEM------- 1705
            .|:   :.|.:..:.:.:|            :..:...:...|    ..|.||.|..|       
Mouse  1445 GGVSDGQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVSVDGC----DTGVALRFGAMLGNYSCA 1505

  Fly  1706 -QKLMNSQQLRQELIDIYAAYGVSEV-ESCSVRRTHAAAIFAGML 1748
             |......:...:|.......||.:: ||..||..|    |.|.:
Mouse  1506 AQGTQGGSKKSLDLTGPLLLGGVPDLPESFPVRMRH----FVGCM 1546

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_648973.1 Cadherin_repeat 33..124 CDD:206637 17/110 (15%)
Cadherin_repeat 132..240 CDD:206637 9/107 (8%)
Cadherin_repeat 249..361 CDD:206637 39/114 (34%)
Cadherin_repeat 487..581 CDD:206637 30/101 (30%)
Cadherin_repeat 589..686 CDD:206637 33/97 (34%)
Cadherin_repeat 713..810 CDD:206637 28/97 (29%)
Cadherin_repeat 819..936 CDD:206637 30/124 (24%)
Cadherin_repeat 953..1049 CDD:206637 25/98 (26%)
Cadherin_repeat 1057..1166 CDD:206637 34/110 (31%)
Cadherin_repeat 1175..1279 CDD:206637 26/103 (25%)
Cadherin_repeat 1293..1390 CDD:206637 21/114 (18%)
Cadherin_repeat 1402..1513 CDD:206637 22/121 (18%)
Cadherin_repeat 1523..1628 CDD:206637 25/172 (15%)
Celsr2NP_059088.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 156..194 11/72 (15%)
Cadherin_repeat 185..285 CDD:206637 39/114 (34%)
Cadherin_repeat 293..395 CDD:206637 37/219 (17%)
Cadherin_repeat 404..501 CDD:206637 34/115 (30%)
Cadherin_repeat 509..606 CDD:206637 29/98 (30%)
Cadherin_repeat 614..708 CDD:206637 30/101 (30%)
Cadherin_repeat 716..811 CDD:206637 26/108 (24%)
Cadherin_repeat 819..917 CDD:206637 34/110 (31%)
Cadherin_repeat 925..1019 CDD:206637 27/105 (26%)
Cadherin_repeat 1042..1120 CDD:206637 16/83 (19%)
EGF_CA 1289..1324 CDD:238011 8/36 (22%)
EGF_CA 1333..1366 CDD:238011 5/32 (16%)
LamG 1369..1552 CDD:238058 33/188 (18%)
EGF_CA 1578..1609 CDD:238011
LamG 1618..1767 CDD:238058
EGF_CA 1795..1829 CDD:238011
Keratin_B2 1806..1956 CDD:366678
EGF_Lam 1924..1969 CDD:214543
HormR 1972..2034 CDD:214468
GAIN 2051..2289 CDD:465137
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2216..2241
GPS 2315..2368 CDD:197639
GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098 2319..2369
7tm_GPCRs 2373..2626 CDD:475119
TM helix 1 2376..2400 CDD:410628
TM helix 2 2409..2430 CDD:410628
TM helix 3 2440..2462 CDD:410628
TM helix 4 2481..2497 CDD:410628
TM helix 5 2516..2539 CDD:410628
TM helix 6 2562..2584 CDD:410628
TM helix 7 2588..2613 CDD:410628
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2690..2884
Blue background indicates that the domain is not in the aligned region.

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