Protein Alignment Cad74A and Cdh24

DIOPT Version :10

• Sequence 1: NP_648973.1
• Gene: Cad74A / 39936
• FlyBaseID: FBgn0036715
• Length: 1820
• Species: Drosophila melanogaster
• Sequence 2: NP_001414210.1
• Gene: Cdh24 / 498515
• RGDID: 1560161
• Length: 781
• Species: Rattus norvegicus
• Alignment Length: 598
• Identity: 158/598 - (26%)
• Similarity: 253/598 - (42%)
• Gaps: 104/598 - (17%)

  Fly   118 VRDYNDNQPTFLGRPYTASVSESLPVGSELSVEPPIVVVDRDEGINSEVQMKCLEENDICDIFEV 182
            :.:|:..:|..:|:.::.                    |||.||....:    |.......:|.:
  Rat    54 IEEYSGPEPVLIGKLHSD--------------------VDRGEGRTKYL----LTGEGAGTVFVI 94

  Fly   183 RAVKISDGNYTARVALKQQLDFESRPSYILTISASDSALDNRLSSLATISINVIDIQDQPPIFTN 247
                   ...|..:.:.:.||.|.:..|:|...|.|.|.:..|...:...|.|.||.|.||:|..
  Rat    95 -------DEATGNIHVTKSLDREEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPVFPL 152

  Fly   248 APYSATVPENTPAGVSILTVKAVDGD----VGIPREIFLSLEDEPFGHFELVPFGDPRDGTAVLQ 308
            .||.|||||.:..|.|::.|.|.|.|    ....:.::..|:..||  |.:    ||:  |.|::
  Rat   153 GPYHATVPEMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLDGLPF--FSV----DPQ--TGVVR 209

  Fly   309 TTSEPLDRENAEILQNGGVYVFSIRATELIDGAIPAEHSLTRVTIVVTDVDDHQPTFSGPHFNVS 373
            |....:|||..|      .::..|:|.:: .|.:......|.||:.::||:|:.|.|....:..|
  Rat   210 TAIPNMDRETQE------EFLVVIQAKDM-GGHMGGLSGSTTVTVTLSDVNDNPPKFPQSLYQFS 267

  Fly   374 ITENLANGMPLPGLSIFVDDRDMGENSRYELSLRDVFNAARVFEVSPTESQGRTPV--VVKVLN- 435
            :.|....|..:..|.  ..|.|:|:|:....|:.| ...:..|.:| |:|||:..:  |.|.|:
  Rat   268 VVETAGPGTLVGRLK--AQDPDLGDNALMAYSILD-GEGSEAFSIS-TDSQGQDGLLTVRKPLDF 328

  Fly   436 ASRLDY--------DVVDPD-LRKFEFDLVASVKGVEKAKTRVEIHLLDANDNAPVFDQGTYRFT 491
            .:|..|        .::||. ||:..|..||||:          :.:.||.: .|.|.|.||...
  Rat   329 ETRRSYTFRVEATNTLIDPAYLRRGPFKDVASVR----------VAVQDAPE-PPAFTQATYHLV 382

  Fly   492 AAENLPVDAIIGHVKATDLDSGEFGHVRY-VLKGFGADN-FYVNPETGGVYLLKPLDYEKQSSYS 554
            ..||.....::|.:.|.|||| ....:|| :|.....:: |.:.||.|.:.....||.|.:..|:
  Rat   383 VPENKAPGTLVGQISANDLDS-PASPIRYSILPHSDPEHCFSIEPEDGTIRTAVRLDREARVWYN 446

  Fly   555 LTVVA--IDGGQREANANLFVGVTDVNDNHPNFESKEYSRTIREGAALFEPQFFVRAHDADGPSQ 617
            |||:|  :|...:.:...:.:...|.|||.|.. ::.|...:.:.||..:....:||.|.|  ..
  Rat   447 LTVLATELDSSAQSSRVQVAIQTLDENDNAPQL-AEPYDLFVCDSAAPGQLIQVIRALDRD--EV 508

  Fly   618 GNGRVKYSIVSENSIAGNVFRIEPDT---------GEIVIQKAARSMDTERGEYELVVSATDFGI 673
            ||.       |:.|:.|.|   .||.         |...:...:|.....:..|.:.:...|:|.
  Rat   509 GNS-------SQVSLQGPV---GPDANFTVRDNRDGSASLLLPSRPAPPRQAPYLVPIELWDWGQ 563

  Fly   674 PPLSNTTRVLVRV 686
            |.||:|..|.|.|
  Rat   564 PALSSTATVTVSV 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad74A	NP_648973.1	Cadherin_repeat	33..124	CDD:206637	1/5 (20%)
		Cadherin_repeat	132..240	CDD:206637	21/107 (20%)
		Cadherin_repeat	249..361	CDD:206637	34/115 (30%)
		Cadherin_repeat	487..581	CDD:206637	28/97 (29%)
		Cadherin_repeat	589..686	CDD:206637	26/105 (25%)
		Cadherin_repeat	713..810	CDD:206637
		Cadherin_repeat	819..936	CDD:206637
		Cadherin_repeat	953..1049	CDD:206637
		Cadherin_repeat	1057..1166	CDD:206637
		Cadherin_repeat	1175..1279	CDD:206637
		Cadherin_repeat	1293..1390	CDD:206637
		Cadherin_repeat	1402..1513	CDD:206637
		Cadherin_repeat	1523..1628	CDD:206637
Cdh24	NP_001414210.1	None