DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad74A and kug

DIOPT Version :9

Sequence 1:NP_001246814.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:NP_001027138.2 Gene:kug / 40191 FlyBaseID:FBgn0261574 Length:4699 Species:Drosophila melanogaster


Alignment Length:2217 Identity:500/2217 - (22%)
Similarity:841/2217 - (37%) Gaps:658/2217 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 MSRFSLSENTPVGSPVFQLKGTDPEGG---RLKYSISGPV--FSVDRETGVVRLRQELDRETQDT 90
            ::.|.|:|:..:|:.|..|..||.:.|   ::.|::|...  |:|:..||.:||.:.||||.||.
  Fly   881 LATFRLTESARIGTVVHCLHATDADSGINAQVTYALSVECSDFTVNATTGCLRLNKPLDREKQDN 945

  Fly    91 VEVIISITDEGIYGTEPNTVSQRRV-IPVRDYNDNQPTFLGRPYTASVSESLPVGSELSVEPPIV 154
            ..:.|:..|    |..|...|:..| :.|.|.|||.|.|..:.|...|.|.||.|:.|:|   |.
  Fly   946 YALHITAKD----GGSPVLSSEALVYVLVDDVNDNAPVFGVQEYIFKVREDLPRGTVLAV---IE 1003

  Fly   155 VVDRDEGINSEVQMKCLEENDICDIFEVRAVKISDGNYTARVALKQQLDFESRPSYILTISASDS 219
            .||.|.|.|:|:|....||....::|.:       ..:|..:..:..||:|::..:.|.:||.|.
  Fly  1004 AVDEDIGPNAEIQFSLKEETQDEELFRI-------DKHTGAIRTQGYLDYENKQVHNLIVSAIDG 1061

  Fly   220 ALDNRLSSLATISINVIDIQDQ--PPIFTNAPYSATVPENTPAGVSILTVKAVDGD--------- 273
            . |..|:|..:|.|.:||:.:.  .|.|.:..|...|.||.|.|..::.|.|.|.|         
  Fly  1062 G-DPSLTSDMSIVIMIIDVNENRFAPEFDDFVYEGKVKENKPKGTFVMNVTARDMDTVDLNSKIT 1125

  Fly   274 --------VGI-----------------------------------PR----EIFLSLE------ 285
                    :||                                   |.    |:::.:|      
  Fly  1126 YSITGGDGLGIFAVNDQGSITSLSQLDAETKNFYWLTLCAQDCAIVPLSNCVEVYIQVENENDNI 1190

  Fly   286 ---DEP-----------------------------------------FGHFELVPFGDPRDGTAV 306
               |:|                                         .|:||:    |.:  |.|
  Fly  1191 PLTDKPVYYVNVTEASVENVEIITLKAFDPDIDPTQTITYNIVSGNLVGYFEI----DSK--TGV 1249

  Fly   307 LQTTSEPLDREN-AEILQNGGVYVFSIRATELIDGAIPAEHSLTRVTIVVTDVDDHQPTFSGPHF 370
            ::||...||||| ||          .|....:.|...|...|.:|:.:.|.|::|:.|.|....:
  Fly  1250 IKTTERKLDRENQAE----------HILEVAISDNGSPVLSSTSRIVVSVLDINDNSPEFDQRVY 1304

  Fly   371 NVSITENLANGMPLPGLSIFVDDRDMGENSRYELSLRD--------------------VFNAARV 415
            .|.:..:......:  ..:...|.|.|||.|...|::.                    ..::...
  Fly  1305 KVQVPSSATVNQSI--FQVHAIDSDSGENGRITYSIKSGKGKNKFRIDSQRGHIHIAKPLDSDNE 1367

  Fly   416 FEVS--------PTESQ---------------GRTPVVVKVLNASRLDYD-------------VV 444
            ||:.        |.:||               ...|::|:..:.:.:|..             .|
  Fly  1368 FEIHIKAEDNGIPKKSQTARVNIVVVPVNPNSQNAPLIVRKTSENVVDLTENDKPGFLVTQILAV 1432

  Fly   445 DPD---------------------------LRKF-------EFDLVASV-KGVEKAKTRVEIHLL 474
            |.|                           |.|:       .::|..|| .|...|.|.:.:.::
  Fly  1433 DDDNDQLWYNISNGNDDNTFYIGQDNGNILLSKYLDYETQQSYNLTISVTDGTFTAFTNLLVQVI 1497

  Fly   475 DANDNAPVFDQGTYRFTAAENLPVDAIIGHVKATDLDSGE--FGHVRYVLKGFGADNFYVNPETG 537
            |.|||.|.|.:..|....:||:..:::|..:.|||.|..:  |.|:...........|.::..:|
  Fly  1498 DINDNPPQFAKDVYHVNISENIEEESVIMQLHATDRDEDKKLFYHLHATQDPSSLALFRIDSISG 1562

  Fly   538 GVYLLKPLDYEKQSSYSLTVVAIDGGQ--REANANLFVGVTDVNDNHPNFESKEYSRTIREGAAL 600
            .|.:.:.||:||.:.:.|.|...|.|.  :...|.:.|.|.|.||:||.|.:|.....:.|.||:
  Fly  1563 NVIVTQRLDFEKTAQHILIVFVKDQGAPGKRNYAKIIVNVHDHNDHHPEFTAKIIQSKVPESAAI 1627

  Fly   601 FEPQFFVRAHDADGPSQGNGRVKYSIVSENSIAGNVFRIEPDTGEIVIQKAARSMDTER-GEYEL 664
            ......|||.|.|  |..|..::|||::.|  .|:||.|:|..|.|.:   |.:::..: .||.|
  Fly  1628 GSKLAEVRAIDRD--SGHNAEIQYSIITGN--VGSVFEIDPTFGIITL---AGNLNINKIQEYML 1685

  Fly   665 VVSATDFGIPPLSNTTRVLVRVGISGNQRPIFRGHFQNMENLPIIGPPSYRVSIP--ENAAAGSN 727
            .|.|.|.|.||||:...|.:.|.:|.|..|.|               |:..::|.  ||...|:.
  Fly  1686 QVKAVDLGNPPLSSQIPVHIIVTMSENDPPKF---------------PTNNIAIEIFENLPIGTF 1735

  Fly   728 VTSVSAHDPDGLDSLLRYRIVGA--NDNFEIDEISGLITVSPQARIDRDSNMNSFEIIVNAVDSG 790
            ||.|:|..    .|.:.:.|:..  |::|.|:..:|:|.::  ..||.:| :..|.:.|...:..
  Fly  1736 VTQVTARS----SSSIFFNIISGNINESFRINPSTGVIVIN--GNIDYES-IKVFNLTVKGTNMA 1793

  Fly   791 TPIPETATTTVYVNVKDINDERPKFEQNSYATYVSERTAVGESVLRVKAIDKD------------ 843
            .   |::...:.:::.|.||..|.|.||.|...:.|..|:|..||:|....||            
  Fly  1794 A---ESSCQNIIIHILDANDNIPYFVQNEYVGALPESAAIGSYVLKVHDSSKDHLTLQVKDADVG 1855

  Fly   844 LNSKLEYSMVGPVAATTKAGVSIANRSNYRLQEAFRVDSQSGEIFVNGTLRHDVAAIIIFTVGVR 908
            :|..:||.:|..:|            .|:     |::||.:|.|.:...|.::..|...|.|.|.
  Fly  1856 VNGMVEYHIVDDLA------------KNF-----FKIDSTTGAIELLRQLDYETNAGYTFDVTVS 1903

  Fly   909 DLNAEVDPEGQVDTT-EVTVYVQSFQDTNPVFKNTGWTSSRPVIDVKIKEEMPIDSALFILQAED 972
            |:.   .|:....|| .||:.|.:..|..|||...         ::.:...:|....:|:.|...
  Fly  1904 DMG---KPKLHSTTTAHVTIRVINVNDCPPVFNER---------ELNVTLFLPTFENVFVRQVSA 1956

  Fly   973 PVTRQPITSFELIEPKQVDYFQVAERTGEVILKKRLDYEAL-GDTGPEFELQVRANSADRQRSTV 1036
            .........|::::....:.||:.:.||.:..:   ::|.| .:...::.|.|||  :|...|.:
  Fly  1957 KDADNDTLRFDIVDGNTNECFQIEKYTGIITTR---NFEILNNENDRDYALHVRA--SDGIFSAI 2016

  Fly  1037 SRVNITVENVNDNSPRFERNSYQATIIENRPHPERVIRVRALDKDAVLNARDERLGYHKIIYSLQ 1101
            ..|.|.|.:..|::..|:|.||:.:..||......:..|..:.     |..||.:.| :|:...|
  Fly  2017 LIVKIKVLSAIDSNFAFQRESYRFSAFENNTKVATIGLVNVIG-----NTLDENVEY-RILNPTQ 2075

  Fly  1102 GEHAMLFDINNTTGEIIVASGQTIDRERTPRIQLQIKAEDS--PGRPTDAKQSVVELQIEVLDVN 1164
                 ||||..::| .:..:|...|||.....:|.::|:..  .|..::.:::|..:.|.|||||
  Fly  2076 -----LFDIGISSG-ALKTTGVIFDREVKDLYRLFVEAKSMLYDGMNSNVRRAVTSIDISVLDVN 2134

  Fly  1165 DNAPEFTQKKYSTVIPENAQIDSFVLQLEAVDADEGLGGEVRYELVNEGEANG-LFKIDTKSGLI 1228
            ||.|.|....|...:..:....:.::|::|:|.|....|||||||   .:.|| |||:|.|||.:
  Fly  2135 DNCPLFVNMPYYATVSIDDPKGTIIMQVKAIDLDSAENGEVRYEL---KKGNGELFKLDRKSGEL 2196

  Fly  1229 STRRNLTGKGRAHPYVLIVRAQDN-----GNQMPKQP---------------TLSTDTDVRIY-- 1271
            |.::::.|..|  .|.|.|.|.|.     .::.|.|.               |:|...||.:|  
  Fly  2197 SIKQHVEGHNR--NYELTVAAYDGAITPCSSEAPLQVKVIDRSMPVFEKQFYTVSVKEDVEMYSA 2259

  Fly  1272 ----------IG-------------------------------------DVS------------- 1276
                      :|                                     |||             
  Fly  2260 LSVSIEAESPLGRSLIYTISSESQSFEIDYNTGSIFVVNELDYEKISSHDVSIRATDSLSGVYAE 2324

  Fly  1277 ---------ANDGVPYFLSPRVGQMANVT--ENAVTGAPVFQVIASDPDDESTPSGTITYRI--L 1328
                     .||..|...|    .:.|:|  |||..|..:.::.|:|.|  |..:..::|.|  :
  Fly  2325 VVLSVSIMDVNDCYPEIES----DIYNLTIPENASFGTQILKINATDND--SGANAKLSYYIESI 2383

  Fly  1329 PDTPDAEAFVIDAHSGLITTRQSMDRETKDMYRILLEVSDNGQPKQSATRILQIAILDVDDHEPR 1393
            ....::|.|.||...|.:..:..:|.|....:.|::.|.|:|.|..|:...:.|.:.|::|:.|.
  Fly  2384 NGQNNSELFYIDVTDGNLYLKTPLDYEQIKYHHIVVNVKDHGSPSLSSRSNVFITVKDLNDNAPC 2448

  Fly  1394 FAREADAGPLSMSVREEEPAGTIVGNFSAL----DEDLGENAAIDYVIIDGNNEQLFTIER---- 1450
            |...:....:|::        .:.|.|.||    |:|:.:..:::|.|:.||..|.::|::    
  Fly  2449 FVEPSYFTKVSVA--------AVRGQFVALPKAYDKDISDTDSLEYKIVYGNELQTYSIDKLTGV 2505

  Fly  1451 ----------------------------------------------------------------- 1450
                                                                             
  Fly  2506 ISLQNMLNFTDKSSTVLNISVSDGVHTAYARLKISLLPENVYSPLFDQSTYEAQVPENLLHGHNI 2570

  Fly  1451 ------------------------------NNESLAILKTKKPIDREQVESFTLTIKCLKLGEPG 1485
                                          .:::..::.:|...|||:.:.:   :..||:.:.|
  Fly  2571 ITVKASDGDFGTYANLYYEIVSEEMKKIFLIDQTTGVITSKVTFDREKKDEY---VVLLKVSDGG 2632

  Fly  1486 YKFIGDPYDRQDLSHLRINVRVLDIDDNLPKFEQPDPTVGIRINVPIDTVVTTLKASDADAEAPP 1550
            .||          ....:.|.|:|::||:|.|...:..:.:...|..:..:.|:||.|.|.    
  Fly  2633 GKF----------GFASLKVIVVDVNDNVPYFLLKEYKMVVSTTVEANQTILTVKAKDDDI---- 2683

  Fly  1551 VGLSIENVTFVPQFYKRSRSLAVGNLHNLFTLNNRTGELRTGGSFADY-VDGY-FLMRVMANNSV 1613
                ::|.:...|..::|...||   .::..:|.:||::........| |:.| |.:|  |::..
  Fly  2684 ----VDNGSVHFQIVQKSNDKAV---KDVIEINEKTGDIVFKSKAESYGVNSYQFFVR--ASDRG 2739

  Fly  1614 QPKRQAHSNLKVFV----------IRDKS--LLKFVFARPPNEI------------QHNIRPFQE 1654
            :|  |.||.:.|.:          ..:||  |||.:.:.||..:            :.:|...|:
  Fly  2740 EP--QFHSEVPVSIEIIETDANIPTFEKSSVLLKIIESTPPGTVLTKLHMIGNYTFKFSIAADQD 2802

  Fly  1655 Q----------LQKKLKPLGLELH----VLDTQV----FTRPDMSLDFTATSSCFQMFKNGAALS 1701
            .          ||:.|.....|.|    |.:|..    |...|:.:|....:..:..|.|    :
  Fly  2803 HFMISDSGELILQQTLDREQQESHNLIVVAETSTVPVFFAYADVLIDVRDENDNYPKFDN----T 2863

  Fly  1702 FNEMQKLMNSQQLRQELIDIYAA------------YGVSEVESCSVRRTHAAAIFAGMLTSAGAW 1754
            |.......||::: ..|:.:.|.            |..|:.|  :::......|::|       |
  Fly  2864 FYSASVAENSEKV-ISLVKVSATDADTGPNGDIRYYLESDTE--NIQNIFDIDIYSG-------W 2918

  Fly  1755 LVFLAAL 1761
            :..|.:|
  Fly  2919 ITLLTSL 2925

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_001246814.1 Cadherin_repeat 33..124 CDD:206637 32/96 (33%)
Cadherin_repeat 132..240 CDD:206637 34/107 (32%)
Cadherin_repeat 249..361 CDD:206637 39/218 (18%)
Cadherin_repeat 369..479 CDD:206637 29/200 (15%)
Cadherin_repeat 487..581 CDD:206637 26/97 (27%)
Cadherin_repeat 589..686 CDD:206637 34/97 (35%)
Cadherin_repeat 713..810 CDD:206637 22/100 (22%)
Cadherin_repeat 819..936 CDD:206637 33/129 (26%)
Cadherin_repeat 953..1049 CDD:206637 19/96 (20%)
Cadherin_repeat 1057..1166 CDD:206637 30/110 (27%)
Cadherin_repeat 1175..1279 CDD:206637 40/195 (21%)
Cadherin_repeat 1293..1390 CDD:206637 27/100 (27%)
Cadherin_repeat 1402..1513 CDD:206637 25/213 (12%)
Cadherin_repeat 1523..1628 CDD:206637 25/116 (22%)
kugNP_001027138.2 Cadherin_repeat 66..178 CDD:206637
Cadherin_repeat 187..285 CDD:206637
E_set 309..390 CDD:298831
Cadherin_repeat 404..503 CDD:206637
Cadherin_repeat 513..609 CDD:206637
Cadherin_repeat 622..708 CDD:206637
Cadherin_repeat 776..873 CDD:206637
Cadherin_repeat 883..976 CDD:206637 32/96 (33%)
Cadherin_repeat 984..1082 CDD:206637 34/108 (31%)
Cadherin_repeat 1092..1189 CDD:206637 15/96 (16%)
Cadherin_repeat 1197..1295 CDD:206637 22/113 (19%)
Cadherin_repeat 1303..1386 CDD:206637 13/84 (15%)
Cadherin_repeat 1413..1502 CDD:206637 14/88 (16%)
Cadherin_repeat 1510..1608 CDD:206637 26/97 (27%)
Cadherin_repeat 1621..1713 CDD:206637 36/98 (37%)
Cadherin_repeat 1724..1811 CDD:206637 23/96 (24%)
Cadherin_repeat 1819..1927 CDD:206637 32/127 (25%)
Cadherin_repeat 1948..2030 CDD:206637 19/86 (22%)
Cadherin_repeat 2037..2136 CDD:206637 30/110 (27%)
Cadherin_repeat 2144..2235 CDD:206637 31/95 (33%)
Cadherin_repeat 2246..2336 CDD:206637 9/89 (10%)
Cadherin_repeat 2345..2445 CDD:206637 27/101 (27%)
Cadherin_repeat 2453..2545 CDD:206637 13/99 (13%)
Cadherin_repeat 2555..>2633 CDD:206637 6/80 (8%)
Cadherin_repeat 2658..2759 CDD:206637 25/115 (22%)
Cadherin_repeat 2774..2856 CDD:206637 14/81 (17%)
Cadherin_repeat 2865..2963 CDD:206637 12/71 (17%)
Cadherin_repeat 2974..3063 CDD:206637
Cadherin_repeat 3072..3165 CDD:206637
Cadherin_repeat 3173..3269 CDD:206637
Cadherin_repeat 3277..3374 CDD:206637
Cadherin_repeat 3383..3479 CDD:206637
Cadherin_repeat 3488..3579 CDD:206637
Cadherin_repeat 3590..3681 CDD:206637
EGF_CA 3866..3903 CDD:238011
Laminin_G_2 3953..4077 CDD:280389
EGF_CA <4121..4150 CDD:238011
EGF_CA 4152..4189 CDD:238011
EGF_CA 4195..4225 CDD:238011
EGF_CA 4227..4262 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24026
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.010

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