DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad74A and celsr1a

DIOPT Version :9

Sequence 1:NP_001246814.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:XP_009298735.1 Gene:celsr1a / 368436 ZFINID:ZDB-GENE-030616-78 Length:3045 Species:Danio rerio


Alignment Length:1552 Identity:373/1552 - (24%)
Similarity:615/1552 - (39%) Gaps:353/1552 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 GPVFSVDRETGVVRLRQELD--RETQDTVEV---IISITDEGIYGTEPNTV--SQRRVIPVRDYN 122
            |....||...|||||..|:|  |.....:.:   |.|:|.||:..|..|..  .|..|...:...
Zfish    60 GNFIKVDWRDGVVRLNGEVDCARAPHSALPLYFKIKSLTTEGLVKTHFNVFLHGQNCVFKFKRKR 124

  Fly   123 DNQPTF-LGRPYTASVSESLPVGSEL-SVEPPIVVVDRDEGI---------------NSEVQMK- 169
            :.:|.. :...|.:.::..|..|..| ..|..:.|..|:..:               |..:.:| 
Zfish   125 ETKPDINVNYIYNSGLTSCLSPGDLLIHFEDYLPVFTRNSAVFASSCTSDQLNVFVRNGTLLVKD 189

  Fly   170 --CLEEN-------DICDIFEVRAVKISDGNYTARVALKQQLDFESRPSYILTISASDSALDNRL 225
              |||.|       ..|...:.:....|       |.||  |.|.|..:   ::|...:....|:
Zfish   190 AYCLETNLGRFKSTIRCSFLDSKGEPFS-------VCLK--LRFTSDQT---SLSYVTNPRKQRI 242

  Fly   226 SSLATISINVIDIQDQPPIFTNAPYSATVPENTPAGVSILTVKAVDGDVGIPREIFLSLE---DE 287
            ...|          :..|.|..:.|..:||||.|||..::|:||...|.|...:|...:|   |.
Zfish   243 KRAA----------NSVPQFQLSNYQVSVPENEPAGTRVITLKATVSDPGETGKIEYGMEALFDS 297

  Fly   288 PFGHFELVPFGDPRDGTAVLQTTSEPLDRENAEILQNGGVYVFSIRATELIDGAIPAEHSLTR-V 351
            ....|..:   ||:.|:.   .|::|||||..:      .:||.:.|:  :.|.  |:.:.|. :
Zfish   298 RSNDFFRI---DPQTGSI---ETAQPLDREVKD------THVFKVTAS--VAGF--AKRAATSYL 346

  Fly   352 TIVVTDVDDHQPTFSGPHFNVSITENLANGMPLPGLSIFVDDRDMGENSR--YELSLRDVFNAAR 414
            ||.|:|.:||.|.|....:.|.|.||:..|..:  :::...|.|...|:.  |.:...:..|:. 
Zfish   347 TITVSDTNDHGPVFEQNEYRVRIRENVEVGFEV--ITVRATDGDAPSNANMIYRIMNEEGVNSG- 408

  Fly   415 VFEVSPTESQGRTPVVVKVLNASRLDYDVVDPD---LRKFEFDLVASVKGVE----KAKTRVEIH 472
             ||:.....      :||:         .|.||   :.:::..:.||.:|.|    .|...|.|.
Zfish   409 -FEIDSWNG------LVKI---------KVRPDRETMAQYQLIVEASDQGKEPGPRSATATVHIT 457

  Fly   473 LLDANDNAPVFDQGTYRFTAAENLPVDAIIGHVKATDLDSGEFGHVRY-VLKGFGADNFYVNPET 536
            :.|.|||.|.|.:..|.....||:.|:..:..|:|||.|.|....|.| ::.|.....|:::..|
Zfish   458 VEDENDNYPQFSEKRYVVQVPENVAVNTKVAQVEATDRDEGNNARVHYSIISGNVKGQFFIHTPT 522

  Fly   537 GGVYLLKPLDYEKQSSYSLTVVAIDGGQR---EANANLFVGVTDVNDNHPNFESKEYSRTIREGA 598
            |.:.::.|||||....|:|.:.|.|||:.   .....:.|.|.|||||.|.|.|..:..|:.|  
Zfish   523 GAIDVINPLDYETIREYNLRIKAQDGGRPPLINGTGVVVVQVVDVNDNAPMFVSTPFQATVLE-- 585

  Fly   599 ALFEPQFFVRAHDADGPSQGNGRVKYSIVSENSIAGNVFRIEPDTGEIVIQKAARSMDTERGEYE 663
                                |..:.||::       ::..|:.|:||           ..|.:|.
Zfish   586 --------------------NVPIGYSVI-------HIQAIDSDSGE-----------NARLDYS 612

  Fly   664 LVVSATDFGIPPLSNTTRVLVRVGISGNQRPIFRGHFQNMENLPIIGPPSYRVSIPENAAAGSNV 728
            |  :.|..|.|                                                      
Zfish   613 L--TDTTPGFP------------------------------------------------------ 621

  Fly   729 TSVSAHDPDGLDSLLRYRIVGANDNFEIDEISGLITVSPQARIDRDSNMNSFEIIVNAVDSGTPI 793
                                     |.|:..:|.||||.:  :||:|. ..:...|.|.|:|.|:
Zfish   622 -------------------------FSINNSTGWITVSDE--LDREST-EFYTFGVEARDNGVPV 658

  Fly   794 PETATTTVYVNVKDINDERPKFEQNSYATYVSERTAVGESVLRVKAIDKDLNSKLEYSMVGPVAA 858
             .:::.:|.:.|.|:||..|.|.:..|:..::|...||.|||.|.|:|:|:||.:.|.       
Zfish   659 -MSSSASVSITVLDVNDNIPTFTEKMYSLKINEDAVVGTSVLTVTALDRDVNSVVTYQ------- 715

  Fly   859 TTKAGVSIANRSNYRLQEAFRVDSQSGEIFVNGTLRHDV--AAIIIFTVGVRDLNAEVDPEGQVD 921
                 :|..|..|     .|.:.||||...:...|..|.  ....:.|:...|       ..:.|
Zfish   716 -----ISSGNTRN-----RFAITSQSGGGLITLALPLDYKQERQYVLTITASD-------GTRFD 763

  Fly   922 TTEVTVYVQSFQDTNPVFKNTGWTSSRPVIDVKIKEEMPIDSALFILQAEDPVTRQPITSFELIE 986
            |.:|.:.|.......|||:|..:..:       ..|:.||.|.:.::.|.|..|.:......::|
Zfish   764 TAQVFINVTDANTHRPVFQNANYHQT-------FSEDQPIGSTVVVISATDEDTGENARITYIME 821

  Fly   987 PKQVDYFQVAERTGEVILKKRLDYEALGDTGPEFELQVRA-NSADRQRSTVSRVNITVENVNDNS 1050
             ..|..|::...:|.:..:..:|||    ....:.|.:.| ::...|:|..:.|.|.:.:.||||
Zfish   822 -DNVPQFKIDPDSGAITTQMEIDYE----DQASYTLAIIARDNGIPQKSDTTYVEIIILDANDNS 881

  Fly  1051 PRFERNSYQATIIENRPHPERVIRVRALDKDAVLNARDERLGYHKIIYSLQG--EHAMLFDINNT 1113
            |||.|:.||.|:.|:.|....|:::.|.|:|:..|.|        :.|:.||  :....|.|...
Zfish   882 PRFGRDKYQGTVFEDAPIYTSVLQISASDRDSGSNGR--------VSYTFQGGDDGEGDFMIEQY 938

  Fly  1114 TGEIIVASGQTIDRERTPRIQLQIKAEDSPGRPTDAKQSVVELQIEVLDVNDNAPEFTQKKYSTV 1178
            :|  |:.:.:.:|||..|...|:..|.|   |.....::.||:|:.|||:|||||.|.:.:....
Zfish   939 SG--IIRTHRKLDRENVPVYNLRAYAVD---RGVPPLKAAVEIQVSVLDINDNAPVFEKDELYID 998

  Fly  1179 IPENAQIDSFVLQLEAVDADEGLGGEVRYELVNEGEANGLFKIDTKSGLISTRRNLTGKGRAHPY 1243
            :.||:.:||.|.::.|:|.|||...::.|::| ||....:|.:|..:|.:....:|..:.:.. |
Zfish   999 VKENSPVDSVVARITAMDPDEGTNAQILYQIV-EGNIPEVFDLDIFTGDLKALVDLDYETQKE-Y 1061

  Fly  1244 VLIVRAQDNGNQMPKQPTLSTDTDVRIYIGDVSANDGV----PYFLSPRVGQMANVTENAVTGAP 1304
            |::|:|       ...|.:|..| |.:.:.||:.||.|    ....:..|...:|...:.:.|  
Zfish  1062 VIVVQA-------TSAPLVSRAT-VHVRLIDVNDNDPVLQNFEIIFNNYVTNKSNSFPSGIIG-- 1116

  Fly  1305 VFQVIASDPDDESTPSGTITYRILPDTPDAEAFVIDAHSGLITTRQSMDRETKDMYRILLEVSDN 1369
              :|.|.|||    .|..:.|..: :..:....:::..:|.:...:.:|........:.:.|:| 
Zfish  1117 --KVPAHDPD----VSDKLKYSFI-EGNELSLLILNPDTGELKLSKDLDNNRPLEATMKVSVTD- 1173

  Fly  1370 GQPKQSATRILQIAIL-------DVDDHEPRFAREADAGP-LSMSVR------EEEPAGTIVGNF 1420
            |..:.:|...|::.|:       .:.......::|....| ||:.|:      .....|..:.|.
Zfish  1174 GIHQVTAFCTLRVTIITDEMLTNSITVRLENMSQERFLSPLLSLFVKGVAAVLSTSREGVFIFNV 1238

  Fly  1421 SALDEDLGE---NAAIDYVIIDGNNEQLFTIERNNESLAILKT-KKPIDREQVESFTLTIKCLKL 1481
            .. |.|:..   |.....::..|..::.|..|...|.:.:.:| .:.|..:.|..|...| ||: 
Zfish  1239 QN-DTDVSGNILNVTFSALLPGGVPDRYFPSEELQEQIYLNRTLLQEISSQNVLPFDDNI-CLR- 1300

  Fly  1482 GEPGYKFIGDPYDRQDLSHLRINVRVLDIDDNLP-------KFEQPDPTVGIRINVP 1531
             ||...::.             .|.||..|.:.|       .|....|..|:|...|
Zfish  1301 -EPCENYMK-------------CVSVLKFDSSPPFIASDTVLFRPIHPINGLRCRCP 1343

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_001246814.1 Cadherin_repeat 33..124 CDD:206637 20/65 (31%)
Cadherin_repeat 132..240 CDD:206637 24/133 (18%)
Cadherin_repeat 249..361 CDD:206637 36/115 (31%)
Cadherin_repeat 369..479 CDD:206637 26/118 (22%)
Cadherin_repeat 487..581 CDD:206637 32/97 (33%)
Cadherin_repeat 589..686 CDD:206637 15/96 (16%)
Cadherin_repeat 713..810 CDD:206637 18/96 (19%)
Cadherin_repeat 819..936 CDD:206637 30/118 (25%)
Cadherin_repeat 953..1049 CDD:206637 21/96 (22%)
Cadherin_repeat 1057..1166 CDD:206637 33/110 (30%)
Cadherin_repeat 1175..1279 CDD:206637 28/103 (27%)
Cadherin_repeat 1293..1390 CDD:206637 17/103 (17%)
Cadherin_repeat 1402..1513 CDD:206637 26/121 (21%)
Cadherin_repeat 1523..1628 CDD:206637 3/9 (33%)
celsr1aXP_009298735.1 Cadherin_repeat 257..356 CDD:206637 36/114 (32%)
Cadherin_repeat 364..464 CDD:206637 26/118 (22%)
Cadherin_repeat 473..553 CDD:206637 27/79 (34%)
Cadherin_repeat 578..675 CDD:206637 34/221 (15%)
Cadherin_repeat 684..777 CDD:206637 30/116 (26%)
Cadherin_repeat 786..880 CDD:206637 21/105 (20%)
Cadherin_repeat 889..986 CDD:206637 33/109 (30%)
Cadherin_repeat 994..1088 CDD:206637 28/103 (27%)
Cadherin_repeat 1108..1189 CDD:206637 16/90 (18%)
EGF_CA 1355..1390 CDD:238011
EGF_CA 1400..1432 CDD:238011
LamG 1435..1645 CDD:238058
EGF 1671..1701 CDD:278437
Laminin_G_2 1737..1869 CDD:280389
TNFRSF 1901..2055 CDD:304602
CRD2 1942..2002 CDD:276900
EGF_Lam 2020..2065 CDD:214543
HormR 2069..2130 CDD:214468
GAIN 2148..2387 CDD:293098
GPS 2417..2462 CDD:280071
7tm_2 2474..2702 CDD:278432
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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