Protein Alignment Cad74A and Cdh10

DIOPT Version :10

• Sequence 1: NP_648973.1
• Gene: Cad74A / 39936
• FlyBaseID: FBgn0036715
• Length: 1820
• Species: Drosophila melanogaster
• Sequence 2: NP_033995.1
• Gene: Cdh10 / 320873
• MGIID: 107436
• Length: 788
• Species: Mus musculus
• Alignment Length: 712
• Identity: 187/712 - (26%)
• Similarity: 315/712 - (44%)
• Gaps: 133/712 - (18%)

  Fly  1129 RTPRIQLQIKAEDSPGRPTDA------KQSVVELQIEVLDVNDNAPEFTQKKYSTVIPENAQIDS 1187
            |||.|| |:.||....| :|.      |:..:..|..:|:      |:|...|           .
Mouse    28 RTPGIQ-QMTAESRAPR-SDGKILHRQKRGWMWNQFFLLE------EYTGSDY-----------Q 73

  Fly  1188 FVLQLEAVDADEGLGGEVRYELVNEGEANGLFKIDTKSGLISTRRNLTGKGRAHPYVLIVRAQDN 1252
            :|.:|.: |.|:| .|.::|.|..:| |..||.||.|:|.|...|.:..:.:|. |.|..:|.:.
Mouse    74 YVGKLHS-DQDKG-DGSLKYILSGDG-AGTLFIIDEKTGDIHATRRIDREEKAF-YTLRAQAINR 134

  Fly  1253 GNQMPKQPTLSTDTDVRIYIGDVSANDGVPYFLSPRVGQMANVTENAVTGAPVFQVIASDPDDES 1317
            ....|.:|    :::..|.|.|:  ||..|.|  |.....|:|.|.:|.|..|.||.|:|.||.|
Mouse   135 RTLRPVEP----ESEFVIKIHDI--NDNEPTF--PEEIYTASVPEMSVVGTSVVQVTATDADDPS 191

  Fly  1318 -TPSGTITYRILPDTPDAEAFVIDAHSGLI-TTRQSMDRETKDMYRILLEVSDNG--QPKQSATR 1378
             ..|..:.|.||...|   .|.::..:|:| |...:|:||.|:.|:::::..|.|  ....|.|.
Mouse   192 YGNSARVIYSILQGQP---YFSVEPETGIIRTALPNMNRENKEQYQVVIQAKDMGGQMGGLSGTT 253

  Fly  1379 ILQIAILDVDDHEPRFAREADAGPLSMSVREEEPAGTIVGNFSALDEDLGENAAIDYVIIDGNNE 1443
            .:.|.:.||:|:.|||.:..    :.:.|.|..|.||.||:..|.|.|.|:||.:||.||||:..
Mouse   254 TVNITLTDVNDNPPRFPQNT----IHLRVLESSPVGTAVGSVKATDADTGKNAEVDYRIIDGDGT 314

  Fly  1444 QLFTI--ERNNESLAILKTKKPIDREQVESFTLTIKCLKLG-EPGYKFIGDPYDRQDLSHLRINV 1505
            .:|.|  |::.:. .|:..|||:|.|....:||.::..... :|.:.::| |:  :|.:.::|::
Mouse   315 DMFDIITEKDTQE-GIITVKKPLDYENRRLYTLKVEAENTHVDPRFYYLG-PF--KDTTIVKISI 375

  Fly  1506 RVLDIDDNLPKFEQPDPTVGIRINVPIDTVVTTLKASDADAEAPPVGLSIENVTFVPQFYKRSRS 1570
            .  |:|:. |.|.:......:..::.:.|::.|:.|.|.|:.:.|:..:::..|
Mouse   376 E--DVDEP-PVFSRSSYLFEVHEDIEVGTIIGTVMARDPDSTSSPIRFTLDRHT----------- 426

  Fly  1571 LAVGNLHNLFTLNNRTGELRTGGSFADYVDGYFLMRVMANNSVQPKRQAHSNLKVFV----IRDK 1631
                :|..:|.:::..|.|.|.......:..:..:.|:|.....||..  :.:.|||    :.|.
Mouse   427 ----DLDRIFNIHSGNGSLYTSKPLDRELSQWHNLTVIAAEINNPKET--TRVSVFVRILDVNDN 485

  Fly  1632 SLLKFVF--------ARPPNEIQHNIRPFQEQLQKKLKPLGLELHVLDTQVFTRPDMSLDFTA-- 1686
            :....||        |||...||      ......|..|||.:..     .|:...::.:||.
Mouse   486 APQFAVFYDTFVCENARPGQLIQ------TISAVDKDDPLGGQKF-----FFSLAAVNPNFTVQD 539

  Fly  1687 ---TSSCFQMFKNG------------AALSFNE--MQKLMNSQQLRQELIDIYAAYGVSEVESCS 1734
               .::.....|||            ..:|.|:  :|....:..:|     :.|......::|||
Mouse   540 NEDNTARILTRKNGFNRHEISTYLLPVVISDNDYPIQSSTGTLTIR-----VCACDSQGNMQSCS 599

  Fly  1735 VRRTHAAAIFAGMLTSAGAWLVFLAALIGLAALVSLCTACCLKKKLKRH----SKRSLQASL 1792
               ..|..:.||:  |.||.:..|..:|.|..:|.|..|  ||::.|:.    ||..::.::
Mouse   600 ---AEALLLPAGL--STGALIAILLCIIILLVIVVLFAA--LKRQRKKEPLILSKEDIRDNI 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad74A	NP_648973.1	Cadherin_repeat	33..124	CDD:206637
		Cadherin_repeat	132..240	CDD:206637
		Cadherin_repeat	249..361	CDD:206637
		Cadherin_repeat	487..581	CDD:206637
		Cadherin_repeat	589..686	CDD:206637
		Cadherin_repeat	713..810	CDD:206637
		Cadherin_repeat	819..936	CDD:206637
		Cadherin_repeat	953..1049	CDD:206637
		Cadherin_repeat	1057..1166	CDD:206637	13/42 (31%)
		Cadherin_repeat	1175..1279	CDD:206637	28/103 (27%)
		Cadherin_repeat	1293..1390	CDD:206637	34/100 (34%)
		Cadherin_repeat	1402..1513	CDD:206637	37/113 (33%)
		Cadherin_repeat	1523..1628	CDD:206637	19/108 (18%)
Cdh10	NP_033995.1	CA	80..158	CDD:214520	27/87 (31%)
		Cadherin_repeat	164..265	CDD:206637	34/103 (33%)
		Cadherin_repeat	273..380	CDD:206637	36/116 (31%)
		Cadherin_repeat	388..485	CDD:206637	19/113 (17%)
		Cadherin_repeat	493..587	CDD:206637	19/109 (17%)
		CADH_Y-type_LIR	721..780	CDD:460041