DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad74A and Fat4

DIOPT Version :9

Sequence 1:NP_001246814.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:XP_006232354.2 Gene:Fat4 / 310341 RGDID:1564291 Length:4981 Species:Rattus norvegicus


Alignment Length:1849 Identity:489/1849 - (26%)
Similarity:755/1849 - (40%) Gaps:451/1849 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 LSENTPVGSPVFQLKGTDPEGGRLK---YSIS--------GPVFSVDRETGVVRLRQELDRETQD 89
            |.|..|:|:.|..::...|.|....   |.:|        |.:|::.|:|||::....||||...
  Rat  1638 LKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRQTGVIQTAAILDREQGA 1702

  Fly    90 TVEVIISITDEGIYGTE-----PNTVSQRRVIPVRDYNDNQPTFLGRPYTASVSESLPVGSELSV 149
            .:.::      .:|..|     |.|......|.::|.|||.|.|.......:|.|::..||::. 
  Rat  1703 CLYLV------DVYAIEKSSAFPRTQRAEVEITLQDINDNPPVFPTDTLDLTVEENIGDGSKIM- 1760

  Fly   150 EPPIVVVDRDEGINSEVQMKCLEENDICDIFEVRAVKISDGNYTARVALKQQLDFESRPSYILTI 214
              .:..:|.|||.|:.|....:...|  |.|.:      |......:|.| :||.|.|..|.|.:
  Rat  1761 --QLTAMDADEGANALVTYALISGAD--DSFRI------DPESGDLIATK-RLDREHRSKYSLLV 1814

  Fly   215 SASDSALDNRLSSLATISINVIDIQDQPPIFTNAPYSATVPENTPAGVSILTVKAVDGDVGIPRE 279
            .|.|..    .||...|:|.:.|:.|..|.|:...||..:||:|..|..:..:.|.|.|.|:..|
  Rat  1815 RADDGL----QSSDMRINITISDVNDHTPRFSRPVYSFDIPEDTTPGSLVAAILATDDDSGVNGE 1875

  Fly   280 I-FLSLEDEPFGHFELVPFGDPRDGTAVLQTTSEPLDRENAEILQNGGVYVFSIRATELIDGAIP 343
            | ::..||:..|.|.|.|.      |.|...| ..||.|..:      .|:.::||.   ||.  
  Rat  1876 ISYVVEEDDGDGVFFLNPV------TGVFNLT-RALDYERQQ------YYILTVRAE---DGG-- 1922

  Fly   344 AEHSLTRVTIVVTDVDDHQPTFSGPHFNVSITENLANGMPLPGLSIFVDDRDMGENSRYELSLR- 407
            .:.:..|....:.|::|:.|.||...::.|:.|||..|..:  |...|.|.|.|.||:...|:. 
  Rat  1923 GQFTTIRAYFNILDINDNPPVFSLSSYSTSLMENLPLGSTV--LVFNVTDADDGVNSQLSYSIAS 1985

  Fly   408 ---------DVFNAARVFEVSPTESQGRTPVVVKVLNASRLDYDVVDPDLRKFEFDLVASVKGVE 463
                     |.....:..:....|||....:|::|       :|:..|...:|            
  Rat  1986 GDSLGQFAVDKHGVLKALKALDRESQSFYNLVIQV-------HDLPQPPASRF------------ 2031

  Fly   464 KAKTRVEIHLLDANDNAPVF--DQGTYRFTAAENLPVDAIIGHVKATDLDSGEFGHVRYVLKGFG 526
            .:..:|.|.|||.|||.|:|  .:.||   ..||.|:|.::...:|||.|||...::.|.|....
  Rat  2032 TSTAQVSIILLDVNDNPPMFLSPKLTY---IPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPA 2093

  Fly   527 ADNFYVNPETGGVYLLKPLDYEKQSSYSLTVVAIDGGQ--REANANLFVGVTDVNDNHPNFESKE 589
            .:.|.:....|.|:|...||.|:.|:|||||||.|.||  ..::..:.|.|.|:|||:|.|....
  Rat  2094 GNKFSIGTIDGEVHLTGELDREEVSNYSLTVVATDKGQPPLSSSTEVVVMVLDINDNNPVFAQAM 2158

  Fly   590 YSRTIREGAALFEPQFFVRAHDADGPSQG-NGRVKYSIVSENSIAGNVFRIEPDTGEIVIQKAAR 653
            |...|:|..........|.|.|.|   :| ||:|:|.||..|:  ...|||:..||.|.:   |:
  Rat  2159 YRVQIKENTLTGTDIIQVSAADND---EGTNGQVRYGIVGGNT--HQEFRIDSVTGAITV---AK 2215

  Fly   654 SMDTER-GEYELVVSATDFGIPPLSNTTRVLVR-------------------------------- 685
            |:|.|. ..|.|.|.|||.|..|.:::..|.:.                                
  Rat  2216 SLDRETIPAYILTVQATDRGSSPRTDSCTVAITLLDMNDFVPVFELSPYSVNVPENLGALPRTIL 2280

  Fly   686 -----------------VGISGNQRPIF------------------RGHFQNM------------ 703
                             |.:.||:...|                  |.||..:            
  Rat  2281 QVVARDDDQGPNSQLSYVLLGGNEDNAFALTASGELRVTQSLDREARDHFVLVVTAADAGSPALT 2345

  Fly   704 -------------ENLPIIGPPSYRVSIPENAAAGSNVTSVSAHDPD-GLDSLLRYRIVGANDNF 754
                         :|:|......|..:|||:|..|::|..|:|.|.| ..::::.|.|:|.|..|
  Rat  2346 GTGTINIIVDDINDNVPTFASNMYFTAIPEDAPTGTDVLLVNASDADAATNAVISYSIIGGNSQF 2410

  Fly   755 EIDEISGLITVSPQARIDRDSNMNSFEIIVNAVDSGTPIPETATTTVYVNVKDINDERPKFEQNS 819
            .|:..:|.|..|  |.:||::..| :.::|.|.|:|:|...:::|:|.|:|.|:||..|:|:.:.
  Rat  2411 TINPSTGQIITS--ALLDRETKDN-YTLVVVASDAGSPESLSSSTSVLVSVTDVNDNPPRFQHHP 2472

  Fly   820 YATYVSERTAVGESVLRVKAIDKDL--NSKLEYSMVGPVAATTKAGVSIANRSNYRLQEAFRVDS 882
            |.|::...|..|..|..|...|.|:  ||:|.||:.|                  |..|.|.:|.
  Rat  2473 YVTHIPSPTPPGSFVFAVTVTDADIGPNSELHYSLSG------------------RNSEKFHIDP 2519

  Fly   883 QSGEIFVNGTLRHDVAAIIIFTVGVRD--------------------------------LNAEVD 915
            ..|.|...|.|  ..|:.:.|:|.|:|                                :..|..
  Rat  2520 LRGAIMAAGPL--SGASEVTFSVHVKDGGSFPKTDSTTVTVRFANKADFPKVRAKEQTFMFPENQ 2582

  Fly   916 PEGQVDTT---------EVTVYVQS------FQ--------------DTNPVFKNTGWTSSR--- 948
            |.|.:.||         .::.|:.|      ||              |...:.|...|..:|   
  Rat  2583 PVGTLVTTITGSSLRGETLSYYIASGNLGNAFQIDPLTGQVSISQPLDFEKIQKYIVWIEARDGG 2647

  Fly   949 ------------PVIDVKIK----EEMPIDSALFILQAEDPVTRQPIT--------------SFE 983
                        .|:|:...    ||.|..|.  ||:...|  |:.:|              ::|
  Rat  2648 FPPFSSYEKLDITVLDINDNAPAFEEDPFVSE--ILENLSP--RKILTVSATDKDSGPNGQLAYE 2708

  Fly   984 LIEPKQVDYFQVAERTGEVILKKRLDYEALGDTGPEFELQVRANSADR---QRSTVSRVNITVEN 1045
            ::...|...|.:...|||:...:.||.|.:.    .:||.|:  |:|:   .:||..:|.|:|.:
  Rat  2709 IVNGNQESSFTINHATGEIRSIRPLDREKIS----YYELTVK--SSDKGSPSQSTSVKVIISVLD 2767

  Fly  1046 VNDNSPRFERNSYQATIIENRPHPERVIRVRALDKDAVLNARDERLGYHKIIYSLQGEHAMLFDI 1110
            .|||:|||.: .:.|.:.||.|....|.||...|:|..:||...        ||: .:.|:.|.|
  Rat  2768 ENDNAPRFSQ-IFSAYVSENSPLGYTVTRVTTSDEDIGINAISR--------YSI-ADTALPFTI 2822

  Fly  1111 NNTTGEIIVASGQTIDRERTPRIQLQIKAEDSPGRPTDAKQSVVELQIEVLDVNDNAPEFTQKKY 1175
            |..||:|:::  :.::||.|.|.::::.|.||....:      .::.|.|.|:|||.|.|::..|
  Rat  2823 NPNTGDIVIS--RPLNREDTDRYRIRVSAHDSGWTVS------TDVTIFVTDINDNTPRFSRPSY 2879

  Fly  1176 STVIPENAQIDSFVLQLEAVDADEGLGGEVRYELVNEGEANGLFKIDTKSGLISTR-----RNLT 1235
            ....||..::.|.|.|:.|.|.|||..|:|.|.:.::.|   .|:|:..:|.|..:     :|::
  Rat  2880 YLDCPELTELGSRVTQVSATDPDEGSNGQVFYFIKSKSE---YFRINATTGEIFNKQVLKYQNVS 2941

  Fly  1236 GKGRA--HPYVLIVRAQDNGNQMPKQPTLSTDTDVRIYIGDVSANDGVPYFLSPRVGQMANVTEN 1298
            |....  :.:..||.|.|.||     |:|.::|.|.  |..|.:||..|.||..:  ....||:|
  Rat  2942 GFSNVNINRHSFIVTASDRGN-----PSLLSETTVT--INTVDSNDNPPQFLKNK--YFTPVTKN 2997

  Fly  1299 AVTGAPVFQVIASDPDDESTPSGTITYRILPDTPDAEAFV----------IDAHSGLITTRQSMD 1353
            ...|..:.:|.|.|..|....|            :.|.||          :|..:|.|:...|:.
  Rat  2998 VKVGTKLIKVTAVDDKDFGLNS------------EVEYFVSNGNHLGKFKLDNDTGWISIASSLV 3050

  Fly  1354 RETKDMYRILLEVSDNGQPKQSATRILQIAILDVDDHEPRFAREADAGPLSMSVREEEPAGTIVG 1418
            .:....:.|.:...|.|.|..|:..::.|.:.:.:.|.|.|::    ..:|.::.|....|::|.
  Rat  3051 SDLNQNFFIRVTAKDKGNPPLSSQVVIHITVTEENYHTPEFSQ----SHISATIPESHSIGSVVR 3111

  Fly  1419 NFSALDEDLGENAAIDYVIIDGNNEQLFTIERNNESLAILKTKKPIDREQVESFTLTIKCLKLG- 1482
            ..||.|.|...|..|.|.|..||.|.:|.|   |.|..::...|.:|.|......:||.....| 
  Rat  3112 TVSARDRDTAMNGLISYNISSGNEEGIFAI---NSSTGVVTLAKALDYELSSKHEMTISATDGGW 3173

  Fly  1483 --EPGYKFIGDPYDRQDLSHLRINVRVLDIDDNLPKFEQPD---PTVGIRINVPIDTVVTTLKAS 1542
              ..||              ..:.|.|:|::||.|.| .||   |||  ..|.|..|.|..|.|:
  Rat  3174 VARTGY--------------CSLTVSVIDVNDNSPVF-VPDEFFPTV--MENAPSGTTVIHLNAT 3221

  Fly  1543 DADAEAPPVGLSIENVTFVPQFYKRSRSLAVGNLHNLFTLNNRTGELRTGGSFADYVDGYFLMRV 1607
            |||:.|..|      :.:..|          .:..:||.::..||.:.|.| |.|:         
  Rat  3222 DADSGANAV------IAYTVQ----------SSDSDLFVIDPNTGVITTQG-FLDF--------- 3260

  Fly  1608 MANNSVQPKRQAHSNLKVFVIRDKSLLKF 1636
                  :.|:..|..:|.|.:.|:....|
  Rat  3261 ------ETKQSYHLTVKAFNVPDEEKCSF 3283

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_001246814.1 Cadherin_repeat 33..124 CDD:206637 26/103 (25%)
Cadherin_repeat 132..240 CDD:206637 29/107 (27%)
Cadherin_repeat 249..361 CDD:206637 31/112 (28%)
Cadherin_repeat 369..479 CDD:206637 28/119 (24%)
Cadherin_repeat 487..581 CDD:206637 36/95 (38%)
Cadherin_repeat 589..686 CDD:206637 34/147 (23%)
Cadherin_repeat 713..810 CDD:206637 34/97 (35%)
Cadherin_repeat 819..936 CDD:206637 37/179 (21%)
Cadherin_repeat 953..1049 CDD:206637 29/116 (25%)
Cadherin_repeat 1057..1166 CDD:206637 31/108 (29%)
Cadherin_repeat 1175..1279 CDD:206637 33/110 (30%)
Cadherin_repeat 1293..1390 CDD:206637 22/106 (21%)
Cadherin_repeat 1402..1513 CDD:206637 30/113 (27%)
Cadherin_repeat 1523..1628 CDD:206637 26/104 (25%)
Fat4XP_006232354.2 Cadherin_repeat 48..131 CDD:206637
Cadherin_repeat 139..246 CDD:206637
Cadherin_repeat 254..349 CDD:206637
Cadherin_repeat 364..471 CDD:206637
Cadherin_repeat 479..577 CDD:206637
Cadherin_repeat 588..685 CDD:206637
Cadherin_repeat 693..789 CDD:206637
Cadherin_repeat 798..889 CDD:206637
Cadherin_repeat 904..992 CDD:206637
Cadherin_repeat 1000..1096 CDD:206637
Cadherin_repeat 1105..1206 CDD:206637
Cadherin_repeat 1215..1311 CDD:206637
Cadherin_repeat 1321..1416 CDD:206637
Cadherin_repeat 1428..1525 CDD:206637
Cadherin_repeat 1540..1622 CDD:206637
Cadherin_repeat 1634..1736 CDD:206637 26/103 (25%)
Cadherin_repeat 1747..1837 CDD:206637 29/105 (28%)
Cadherin_repeat 1845..1940 CDD:206637 31/112 (28%)
Cadherin_repeat 1948..2047 CDD:206637 28/119 (24%)
Cadherin_repeat 2057..2150 CDD:206637 36/95 (38%)
Cadherin_repeat 2159..2254 CDD:206637 34/102 (33%)
Cadherin_repeat 2263..2360 CDD:206637 7/96 (7%)
Cadherin_repeat 2369..>2443 CDD:206637 27/76 (36%)
Cadherin_repeat 2472..2559 CDD:206637 27/106 (25%)
Cadherin_repeat 2573..2667 CDD:206637 15/93 (16%)
Cadherin_repeat 2675..2771 CDD:206637 27/105 (26%)
Cadherin_repeat 2778..2870 CDD:206637 31/108 (29%)
Cadherin_repeat 2878..2981 CDD:206637 34/112 (30%)
Cadherin_repeat 2990..3085 CDD:206637 22/106 (21%)
Cadherin_repeat 3095..3192 CDD:206637 30/113 (27%)
Cadherin_repeat 3200..3295 CDD:206637 29/118 (25%)
Cadherin_repeat 3305..3402 CDD:206637
Cadherin_repeat 3410..3508 CDD:206637
Cadherin_repeat 3516..3612 CDD:206637
EGF_CA 3804..3862 CDD:238011
EGF_CA 3864..3900 CDD:238011
EGF_CA 3902..3938 CDD:238011
EGF_CA 3941..3976 CDD:238011
LamG 3979..4142 CDD:238058
EGF_CA 4168..4200 CDD:238011
Laminin_G_2 4252..4375 CDD:396680
EGF_CA 4430..4464 CDD:238011
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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