DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad74A and Celsr1

DIOPT Version :10

Sequence 1:NP_648973.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:XP_006242229.1 Gene:Celsr1 / 300128 RGDID:1560078 Length:3064 Species:Rattus norvegicus


Alignment Length:1603 Identity:384/1603 - (23%)
Similarity:616/1603 - (38%) Gaps:397/1603 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   212 LTISASDSALDNRLSSLATISINVIDIQDQP-----------------PIFTNAPYSATVPENTP 259
            |.:.|: |...:...|::..|:|    |.||                 |.|....|..:||||.|
  Rat   215 LVVEAT-SGTPSESPSVSPSSLN----QSQPRAGVVRRSRRGAGSSTSPQFPLPSYQVSVPENEP 274

  Fly   260 AGVSILTVKAVDGDVGIPREIFLSLE---DEPFGHFELVPFGDPRDGTAVLQTTSEPLDRENAEI 321
            ||.:::.::|.|.|.|....:...:|   ||....:.|:      |.|....||:..||||..: 
  Rat   275 AGTAVIELRAHDPDEGEAGRLSYQMEALFDERSNGYFLI------DATTGAVTTARALDRETKD- 332

  Fly   322 LQNGGVYVFSIRATELIDGAIPAEHSLTRVTIVVTDVDDHQPTFSGPHFNVSITENLANGMPLPG 386
                 .:|..:.|   :|...|...:.|.:|:.|:|.:||.|.|....:...|.|||..|..:  
  Rat   333 -----THVLKVSA---VDHGSPRRSAATYLTVTVSDTNDHSPVFEQSEYRERIRENLEVGYEV-- 387

  Fly   387 LSIFVDDRDMGENS--RYELSLRDVFNAARVFEVSPTESQGRTPVVVKVLNASRLDYDVVDPDLR 449
            |:|...|.|...|:  ||.|    :..|..|||:.......||..||....|:            
  Rat   388 LTIRATDGDAPSNANMRYRL----LEGAGGVFEIDARSGVVRTRAVVDREEAA------------ 436

  Fly   450 KFEFDLVASVK------GVEKAKTRVEIHLLDANDNAPVFDQGTYRFTAAENLPVDAIIGHVKAT 508
              |:.|:....      |...|...|.|.:.|.|||.|.|.:..|.....|::.|:..:..|:||
  Rat   437 --EYQLLVEANDQGRNPGPLSASATVHIVVEDENDNYPQFSEKRYVVQVPEDVAVNTPVLRVQAT 499

  Fly   509 DLDSGEFGHVRY-VLKGFGADNFYVNPETGGVYLLKPLDYEKQSSYSLTVVAIDGGQR---EANA 569
            |.|.|:...:.| ::.|.....||::..:|.:.::.|||:|....|:|.:.|.|||:.   .::.
  Rat   500 DRDQGQNAAIHYSIVSGNLKGQFYLHSLSGSLDVINPLDFEAIREYTLRIKAQDGGRPPLINSSG 564

  Fly   570 NLFVGVTDVNDNHPNFESKEYSRTIREGAALFEPQFFVRAHDADGPSQGNGRVKYSIVSENSIAG 634
            .:.|.|.|||||.|.|.|..:...:.|...|......::|.|||...  |.|::|.:|       
  Rat   565 LVSVQVLDVNDNAPIFVSSPFQAAVLENVPLGHSVLHIQAVDADAGE--NARLQYRLV------- 620

  Fly   635 NVFRIEPDTGEIVIQKAARSMDTERGEYELVVSATDFGIPPLSNTTRVLVRVGISGNQRPIFRGH 699
                   ||...::  ...|:|:|.     .|||.||                            
  Rat   621 -------DTASTIL--GGSSIDSEN-----PVSAPDF---------------------------- 643

  Fly   700 FQNMENLPIIGPPSYRVSIPENAAAGSNVTSVSAHDPDGLDSLLRYRIVGANDNFEIDEISGLIT 764
                                                                 .|:|...||.||
  Rat   644 -----------------------------------------------------PFQIHNSSGWIT 655

  Fly   765 VSPQARIDRDSNMNSFEIIVNAVDSGTPIPETATTTVYVNVKDINDERPKFEQNSYATYVSERTA 829
            |.  |.:||:. :..:...|.|||.|:| |.:::.:|.:.|.|:||..|.|.|..|...::|..|
  Rat   656 VC--AELDREL-LEHYSFGVEAVDHGSP-PMSSSASVSITVLDVNDNDPVFTQPVYELRLNEDAA 716

  Fly   830 VGESVLRVKAIDKDLNSKLEYSMVGPVAATTKAGVSIANRSNYRLQEAFRVDSQSGEIFVNGTL- 893
            ||.|||.::|.|:|.||.:.|.:.|            .|..|     .|.:.||||...:...| 
  Rat   717 VGSSVLTLRARDRDANSVITYQLTG------------GNTRN-----RFALSSQSGGGLITLALP 764

  Fly   894 ------RHDVAAIIIFTVGVRDLNAEVDPEGQVDTTEVTVYVQSFQDTNPVFKNTGWTSSRPVID 952
                  |..|.|:.. :.|.|...|:|    .::.|:...:       .|||:::.:|       
  Rat   765 LDYKQERQYVLAVTA-SDGTRSHTAQV----FINVTDANTH-------RPVFQSSHYT------- 810

  Fly   953 VKIKEEMPIDSALFILQAEDPVTRQPI-TSFELIEPKQVDYFQVAERTGEVILKKRLDYEALGDT 1016
            |.:.|:.|:.:::..:.|.|..|.:.. .::.|.:|  |..|::...||.:.....||||    .
  Rat   811 VSVSEDRPVGTSIATISATDEDTGENARITYVLEDP--VPQFRIDPDTGTIYTMTELDYE----D 869

  Fly  1017 GPEFELQVRA-NSADRQRSTVSRVNITVENVNDNSPRFERNSYQATIIENRPHPERVIRVRALDK 1080
            ...:.|.:.| ::...|:|..:.:.|.:.:.|||:|||.|:.||.::.|:.|....|::|.|.|:
  Rat   870 QAAYTLAITAQDNGIPQKSDTTSLEILILDANDNAPRFLRDFYQGSVFEDAPPSTSVLQVSATDR 934

  Fly  1081 DAVLNARDERLGYHKIIYSLQG--EHAMLFDINNTTGEIIVASGQTIDRERTPRIQLQIKAEDSP 1143
            |:..|.|        ::|:.||  :....|.|..|:|  ::.:.:.:|||......|...|.|. 
  Rat   935 DSGPNGR--------LLYTFQGGDDGDGDFYIEPTSG--VIRTQRRLDRENVAVYNLWALAVDR- 988

  Fly  1144 GRPTDAKQSVVELQIEVLDVNDNAPEFTQKKYSTVIPENAQIDSFVLQLEAVDADEGLGGEVRYE 1208
            |.|.....| ||:|:.|||:|||.|.|.:.:....:.||:.:.|.|.::.|.|.|||...::.|:
  Rat   989 GNPNPLSAS-VEVQVTVLDINDNPPVFEKDELELFVEENSPVGSVVARIRANDPDEGPNAQIMYQ 1052

  Fly  1209 LVNEGEANGLFKIDTKSGLISTRRNLTGKGRAHPYVLIVRAQDNGNQMPKQPTLSTDTDVRIYIG 1273
            :| ||....:|::|..||.:.....|..:.| ..|:|:|:|       ...|.:|..|   ::|.
  Rat  1053 IV-EGNVPEVFQLDLLSGDLRALVELDFEVR-RDYMLVVQA-------TSAPLVSRAT---VHIR 1105

  Fly  1274 DVSANDGVP------YFLSPRVGQMANVTENAVTGAPVFQVIASDPDDESTPSGTITYRILPDTP 1332
            .:..||..|      ...:..|...:|...:.|.|    ::.|.|||    .|.::.|..|... 
  Rat  1106 LLDQNDNPPELPDFQILFNNYVTNKSNSFPSGVIG----RIPAHDPD----LSDSLNYTFLQGN- 1161

  Fly  1333 DAEAFVIDAHSGLITTRQSMDRETKDMYRILLEVS-DNGQPKQSATRILQIAILDVDD------- 1389
            :....::|..:|.:  :.|.|.:.......|:||| .:|....:|...|::.|: .||       
  Rat  1162 ELSLLLLDPATGEL--QLSRDLDNNRPLEALMEVSVSDGVHSVTALCTLRVTII-TDDMLTNSIT 1223

  Fly  1390 -HEPRFAREADAGP-LSMSVREEEPAGTIVGN-------FSAL-DEDLGE---NAAIDYVIIDGN 1441
             .....::|....| ||:.|   |...|::..       |:.. |.|:..   |.....::..|.
  Rat  1224 VRLENMSQERFLSPLLSLFV---EGVATVLSTTKDDIFVFNIQNDTDVSSNILNVTFSALLPGGA 1285

  Fly  1442 NEQLFTIERNNESLAILKT-KKPIDREQVESFTLTIKCLKLGEPGYKFIGDPYDRQDLSHLRINV 1505
            ..:.|..|...|.:.:.:| ...|..::|..|...| ||:  ||...::      :.:|.||.:.
  Rat  1286 RGRFFPSEDLQEQIYLNRTLLTTISAQRVLPFDDNI-CLR--EPCENYM------KCVSVLRFDS 1341

  Fly  1506 RVLDIDDNLPKFEQPDPTVGIRINVP-------IDTVVTTLKASDADAEAPPVGLSIENVTFVPQ 1563
            ....|......|....|..|:|...|       .:|.:....::...|..               
  Rat  1342 SAPFISSTTVLFRPIHPITGLRCRCPPGFTGDYCETEIDLCYSNPCGANG--------------- 1391

  Fly  1564 FYKRSRSLAVGNLHNLF--------TLNNRTGE-----LRTGGSFADYVDGYFLMRVMANNSVQP 1615
               |.||...|.....|        .:|.|:|.     .:.||:..:.:.|.|            
  Rat  1392 ---RCRSREGGYTCECFEDFTGEHCQVNVRSGRCASGVCKNGGTCVNLLIGGF------------ 1441

  Fly  1616 KRQAHSNLKVFVIRDKSLLKFVFARPPNEIQH-----NIRPFQEQLQKKLKPLGLELHVLDTQVF 1675
                |.                 ..||.|.:|     :.|.|..|.....:.|....|      |
  Rat  1442 ----HC-----------------VCPPGEYEHPYCEVSTRSFPPQSFVTFRGLRQRFH------F 1479

  Fly  1676 TRPDMSLDFTATSSCFQMFKNGAALSFNEMQKLMNSQQLRQEL 1718
            |   :||.|........:..||   .|||....:..:.:.::|
  Rat  1480 T---VSLAFATQDRNALLLYNG---RFNEKHDFIALEIVEEQL 1516

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_648973.1 Cadherin_repeat 33..124 CDD:206637
Cadherin_repeat 132..240 CDD:206637 6/27 (22%)
Cadherin_repeat 249..361 CDD:206637 32/114 (28%)
Cadherin_repeat 487..581 CDD:206637 29/97 (30%)
Cadherin_repeat 589..686 CDD:206637 20/96 (21%)
Cadherin_repeat 713..810 CDD:206637 20/96 (21%)
Cadherin_repeat 819..936 CDD:206637 31/123 (25%)
Cadherin_repeat 953..1049 CDD:206637 22/97 (23%)
Cadherin_repeat 1057..1166 CDD:206637 34/110 (31%)
Cadherin_repeat 1175..1279 CDD:206637 27/103 (26%)
Cadherin_repeat 1293..1390 CDD:206637 24/105 (23%)
Cadherin_repeat 1402..1513 CDD:206637 27/123 (22%)
Cadherin_repeat 1523..1628 CDD:206637 18/124 (15%)
Celsr1XP_006242229.1 Cadherin_repeat 264..364 CDD:206637 32/114 (28%)
Cadherin_repeat 372..470 CDD:206637 30/117 (26%)
Cadherin_repeat 479..576 CDD:206637 29/96 (30%)
Cadherin_repeat 584..698 CDD:206637 41/221 (19%)
Cadherin_repeat 706..800 CDD:206637 31/115 (27%)
Cadherin_repeat 808..903 CDD:206637 23/107 (21%)
Cadherin_repeat 912..1010 CDD:206637 34/109 (31%)
Cadherin_repeat 1018..1112 CDD:206637 28/105 (27%)
Cadherin_repeat 1132..1213 CDD:206637 21/91 (23%)
EGF_CA 1379..1414 CDD:238011 6/52 (12%)
EGF_CA 1422..1456 CDD:238011 9/66 (14%)
LamG 1459..1642 CDD:238058 16/70 (23%)
EGF_CA 1666..1700 CDD:238011
Laminin_G_2 1734..1864 CDD:460494
EGF_CA 1889..1923 CDD:238011
EGF_CA 1923..1961 CDD:214542
TNFRSF <1930..2026 CDD:473981
EGF_Lam 2017..>2055 CDD:238012
HormR 2067..2128 CDD:214468
GAIN 2145..2396 CDD:465137
GPS 2422..2475 CDD:197639
7tm_GPCRs 2480..2733 CDD:475119
TM helix 1 2483..2507 CDD:410628
TM helix 2 2516..2537 CDD:410628
TM helix 3 2547..2569 CDD:410628
TM helix 4 2588..2604 CDD:410628
TM helix 5 2623..2646 CDD:410628
TM helix 6 2669..2691 CDD:410628
TM helix 7 2695..2720 CDD:410628
Blue background indicates that the domain is not in the aligned region.

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